Cold Spring Harbor Laboratory

Medical research

Disarming the immune system's lethal lung response

Neutrophils, the most abundant type of white blood cell, are the body's first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils. When activated, neutrophils employ various weapons ...

Genetics

Exposing the evolutionary weak spots of the human genome

Mutations can be good and bad. Sometimes they help an organism adapt and survive. Other times they are so harmful that an organism can't survive or reproduce. Cold Spring Harbor Laboratory (CSHL) Professor Adam Siepel's team ...

Immunology

How the thymus trains T cells to fight infections

T cells are a special class of white blood cells that patrol the body and attack infected or foreign tissue. They learn to distinguish friendly proteins from dangerous ones in an organ called the thymus. However, when T cells ...

Oncology & Cancer

How organoids can guide pancreatic cancer therapy

Cold Spring Harbor Laboratory (CSHL) is at the forefront of using organoid technology to study and treat cancer. Organoids are tiny 3D clusters of cells that are miniature versions of patients' tumors. Now, CSHL Cancer Center ...

Medical research

A new treatment approach for cystic fibrosis

Antisense oligonucleotides, or ASOs, are molecules that can be used to control protein levels in cells. Cold Spring Harbor Laboratory Professor Adrian Krainer leveraged ASO technology to develop the first FDA-approved treatment ...

Medical research

Getting tough on tuft cell lung cancer

Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc's team discovered in 2018 a new type of small-cell lung cancer. The cancer originates from cells known as tuft cells. The prognosis for tuft cell lung cancer ...

Neuroscience

Researchers discover how hormones define brain sex differences

Sex hormones play an important role in shaping an animal's behavior, and their influence starts early. Early-life hormonal surges help shape the developing brain, establishing circuitry that will influence behavior for a ...

Oncology & Cancer

Paving a path to triple-negative breast cancer treatment

It's the cancer version of "mini me." Cold Spring Harbor Laboratory (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived ...

Neuroscience

Maternal protective behaviors run deep

The image of a mouse mom fetching her pup safely home calls to mind a human mother's rapid response when their toddler wanders toward danger. Neuroscientists at Cold Spring Harbor Laboratory (CSHL) now report this resemblance ...

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