Cold Spring Harbor Laboratory

Neuroscience

Uncovering how immune cells nurture brain connections

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, ...

Oncology & Cancer

Pushing past pancreatic tumors' defenses

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system. Cold Spring Harbor Laboratory Professor Douglas Fearon and his former ...

Diseases, Conditions, Syndromes

Drug halts immune reactions to save damaged lungs

A team of scientists led by Cold Spring Harbor Laboratory (CSHL) have discovered that disulfiram, an FDA-approved drug, prevents the immune system from producing toxic webs known as neutrophil extracellular traps (NETs). ...

Oncology & Cancer

Cutting off liver cancer's nutrient supply chain

The World Health Organization projects that starting in 2030, over a million people will die each year from liver cancer. Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer, former postdoc Wai Kit Ma, and Dillon ...

Neuroscience

Finding structure in the brain's static

While sleeping, the entire brain rolls through long, slow waves of electrical activity, like waves on a calm ocean. Researchers call that state of consciousness "slow wave sleep." Waking up changes the pattern of electrical ...

Genetics

Editing RNA to fix protein problems in cystic fibrosis

The process of generating proteins from genes is akin to a factory, where workers follow a set of instructions that, ideally, are effective and clear. But for some people who suffer from cystic fibrosis (CF), one of their ...

Oncology & Cancer

Obscure protein is spotlighted in fight against leukemia

Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc and former graduate student ...

Genetics

Fine-tuning motivation in the brain

A characteristic of depression is a lack of motivation. Cold Spring Harbor Laboratory (CSHL) Professor Bo Li, in collaboration with CSHL Adjunct Professor Z. Josh Huang, discovered a group of neurons in the mouse brain that ...

Oncology & Cancer

In breast cancer, the best defense is a strong offense

Your immune system is constantly patrolling your body to keep you healthy. Sometimes, immune cells are also called into action to address a potential problem. Cold Spring Harbor Laboratory (CSHL) Associate Professor Camila ...

Oncology & Cancer

Breaking the chain that culminates in cancer

In a line of dominos, if you take out a single piece, the last one will never fall. Similarly, a lot of pieces have to line up and be pushed at the same time in a cell to result in cancer. Twenty-two years ago, Cold Spring ...

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