Cold Spring Harbor Laboratory

Neuroscience

How does the brain process fear?

When a frightful creature startles you, your brain may activate its fear-processing circuitry, sending your heart racing to help you escape the threat. It's also the job of the brain's fear-processing circuits to help you ...

Neuroscience

How a mouse's brain bends time

Life has a challenging tempo. Sometimes, it moves faster or slower than we'd like. Nevertheless, we adapt. We pick up the rhythm of conversations. We keep pace with the crowd walking a city sidewalk.

Neuroscience

Research revises our knowledge of how the brain learns to fear

Our brains wire themselves up during development according to a series of remarkable genetic programs that have evolved over millions of years. But so much of our behavior is the product of things we learn only after we emerge ...

Medical research

A new treatment approach for cystic fibrosis

Antisense oligonucleotides, or ASOs, are molecules that can be used to control protein levels in cells. Cold Spring Harbor Laboratory Professor Adrian Krainer leveraged ASO technology to develop the first FDA-approved treatment ...

Neuroscience

Uncovering how immune cells nurture brain connections

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, ...

Neuroscience

Abnormal neuron activity manifests as parental neglect

The brain undergoes dramatic change during the first years of life. Its circuits readily rewire as an infant and then child encounters new sights and sounds, taking in the world and learning to understand it. As the child ...

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