Columbia University Medical Center

Genetics

New ALS gene and signaling pathways identified

Using advanced DNA sequencing methods, researchers have identified a new gene that is associated with sporadic amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. ALS is a devastating neurodegenerative disorder ...

Neuroscience

Diverse autism mutations lead to different disease outcomes

People with autism have a wide range of symptoms, with no two people sharing the exact type and severity of behaviors. Now a large-scale analysis of hundreds of patients and nearly 1000 genes has started to uncover how diversity ...

Diseases, Conditions, Syndromes

Cause of malaria drug resistance in SE Asia identified

Growing resistance to malaria drugs in Southeast Asia is caused by a single mutated gene inside the disease-causing Plasmodium falciparum parasite, according to a study led by David Fidock, PhD, professor of microbiology ...

Medical research

Meniscus regenerated with 3-D printed implant

Columbia University Medical Center researchers have devised a way to replace the knee's protective lining, called the meniscus, using a personalized 3D-printed implant, or scaffold, infused with human growth factors that ...

Neuroscience

Children with autism have extra synapses in brain

Children and adolescents with autism have a surplus of synapses in the brain, and this excess is due to a slowdown in a normal brain "pruning" process during development, according to a study by neuroscientists at Columbia ...

Medical research

FDA-approved drug restores hair in patients with Alopecia Areata

Researchers at Columbia University Medical Center (CUMC) have identified the immune cells responsible for destroying hair follicles in people with alopecia areata, a common autoimmune disease that causes hair loss, and have ...

Medical research

Patient-specific stem cells and personalized gene therapy

(Medical Xpress)—Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, ...

Neuroscience

Uncovering clues to the genetic cause of schizophrenia

The overall number and nature of mutations—rather than the presence of any single mutation—influences an individual's risk of developing schizophrenia, as well as its severity, according to a discovery by Columbia University ...

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