Federation of American Societies for Experimental Biology

Oncology & Cancer

PML as potential treatment for pancreatic cancer

A recent study in The FASEB Journal identifies a new mechanism of pancreatic tumors' resistance to chemotherapeutic treatment. The mechanism involves the loss of function of promyelocytic leukemia protein (PML), which operates ...

Immunology

Gut microbiota linked to organ damage in patients with sepsis

Sepsis is a serious condition that can result in organ failure and even death. A novel human study published in The FASEB Journal demonstrates for the first time that the gut microbiota of patients with sepsis plays a major ...

Diseases, Conditions, Syndromes

CFTR inhibition: The key to treating bile acid diarrhea?

Estimates are that roughly 1 percent of people in Western countries may have bile acid diarrhea, including patients with Crohn's disease, ileal resection, diarrhea-predominant irritable bowel syndrome (IBS-D), and chronic ...

Arthritis & Rheumatism

New psoriatric arthritis mouse model developed

Psoriatic arthritis (PsA) is a chronic inflammatory disease that can reduce mobility and agility in patients. PsA is known to increase the risk of type II diabetes. A recent study published in The FASEB Journal tested a novel ...

Oncology & Cancer

Alternative molecular mechanisms observed in cancer cells

Current anti-cancer drugs can be quite effective but too often, tumors are not fought off completely and end up returning. A recent study published in The FASEB Journal provides the first evidence that some cancer cells evade ...

Genetics

DNA repair gene linked to male infertility

A key DNA repair gene known as X-ray repair cross-complementing group 1, or XRCC1, plays a vital role in maintaining genomic stability and is highly expressed in the early stages of sperm cell development (also known as spermatogenesis). ...

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