Gladstone Institutes
Scientists discover that DNA damage occurs as part of normal brain activity
Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process. The team further ...
Alzheimer's disease & dementia
Mar 24, 2013 |
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Study identifies biological mechanism that plays key role in early-onset dementia
Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. ...
Neuroscience
Oct 08, 2012 |
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Scientists map the genomic blueprint of the heart
Scientists at the Gladstone Institutes have revealed the precise order and timing of hundreds of genetic "switches" required to construct a fully functional heart from embryonic heart cells—providing new ...
Medical research
Sep 13, 2012 |
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Epilepsy drug levetiracetam reverses memory loss in animal model of Alzheimer's disease
Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease.
Alzheimer's disease & dementia
Aug 06, 2012 |
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Scientists turn skin cells into brain cells
Scientists at the Gladstone Institutes have for the first time transformed skin cells—with a single genetic factor—into cells that develop on their own into an interconnected, functional network of brain cells. ...
Medical research
Jun 07, 2012 |
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In breakthrough study damaged mouse hearts regenerated by transforming scar tissue into beating heart muscle
Scientists at the Gladstone Institutes today are announcing a research breakthrough in mice that one day may help doctors restore hearts damaged by heart attacks—by converting scar-forming cardiac cells into beating ...
Cardiology
Apr 18, 2012 |
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Researchers find genetic mechanism linked to congenital heart disease
Scientists at the Gladstone Institutes have identified a finely tuned mechanism by which fetal heart muscle develops into a healthy and fully formed beating heart—offering new insight into the genetic causes of congenital ...
Genetics
Jan 22, 2012 |
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Scientists provide global view of how HIV hijacks cells during infection
In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by researchers at the University of California, San Francisco has mapped every apparent physical interaction the ...
HIV & AIDS
Dec 21, 2011 |
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Study identifies powerful infection strategy of widespread and potentially lethal virus
Scientists at the Gladstone Institutes have mapped the molecular mechanism by which a virus known as cytomegalovirus (CMV) so successfully infects its hosts. This discovery paves the way for new research avenues aimed at ...
Medical research
Dec 20, 2012 |
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Scientists discover novel mechanism by which calorie restriction influences longevity
Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet—called a "ketogenic diet"—could delay the effects of aging. This fundamental discovery reveals how ...
Medical research
Dec 06, 2012 |
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Study: 'ApoE is an ideal target for halting progression of Alzheimer's disease'
Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods ...
Alzheimer's disease & dementia
Dec 05, 2012 |
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Scientists block toxic protein that plays key role in Lou Gehrig's disease
October 28, 2012— Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point ...
Medical research
Oct 28, 2012 |
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Research underscores Truvada's potency in preventing the transmission of HIV
New research from an international team of HIV/AIDS experts has reaffirmed the effectiveness of Truvada—the first and only medication approved by the FDA for HIV prevention. Led by Gladstone Investigator Robert Grant, MD, ...
HIV & AIDS
Sep 12, 2012 |
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Scientists develop technique to decipher the dormant AIDS virus concealed in cells
Scientists at the Gladstone Institutes have gotten us one step closer to understanding and overcoming one of the least-understood mechanisms of HIV infection—by devising a method to precisely track the life cycle of individual ...
HIV & AIDS
Sep 11, 2012 |
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Scientists identify mechanism that could contribute to problems in Alzheimer's
Scientists at the Gladstone Institutes have unraveled a process by which depletion of a specific protein in the brain contributes to the memory problems associated with Alzheimer's disease. These findings provide new insights ...
Alzheimer's disease & dementia
Apr 26, 2012 |
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