Gladstone Institutes

Neuroscience

Could targeting an Alzheimer's-associated protein prevent autism?

Autism manifests in myriad forms. Symptoms and severity vary from person to person, but all autism spectrum disorders share three core symptoms: impaired social interactions, communication deficits, and excessive repetitive ...

Medical research

Scientists identify new human genes controlling HIV infection

Viruses are parasites. The only way they can grow is by hijacking their hosts. When they infect a human host, viruses use human proteins to multiply and modify the human cells to sustain the infection. At the same time, the ...

Alzheimer's disease & dementia

Predicting Alzheimer's disease-like memory loss before it strikes

For a person with Alzheimer's disease, there's no turning back the clock. By the time she begins to experience memory loss and other worrisome signs, cognitive decline has already set in. And decades of clinical trials have ...

Genetics

A new framework to study congenital heart defects

Each year, 9 months of dreams and anticipation shared by millions of parents-to-be turn to despair and fright when learning their child is born with a birth defect; an often-devastating event affecting one out of 20 children ...

Alzheimer's disease & dementia

A new culprit of cognitive decline in Alzheimer's disease

It has long been known that patients with Alzheimer's disease have abnormalities in the vast network of blood vessels in the brain. Some of these alterations may also contribute to age-related cognitive decline in people ...

Medical research

Scientists uncover new gatekeeper function of anti-aging molecule

The protein klotho has been shown to promote longevity and counteract aging-related impairments. Having more klotho seems to allow for longer and healthier lives, whereas a depletion of this molecule accelerates aging and ...

Immunology

New immunotherapy targeting blood-clotting protein

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier—which keeps large molecules in the blood from entering the brain—becomes abnormally permeable, ...

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