Institute for Quality and Efficiency in Health Care
Added benefit of saxagliptin/metformin combination is not proven
The fixed combination of the drugs saxagliptin and metformin (Komboglyze) has been approved in Germany since November 2011 for the treatment of type 2 diabetes mellitus. In an early benefit assessment pursuant to the "Act ...
Medications
Apr 29, 2013 |
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Benefit of PET or PET/CT in bone and soft tissue tumors is not proven
For patients with bone and soft tissue tumours, the study data currently available allow no robust conclusions as to the advantages and disadvantages of using positron emission tomography (PET), alone or in combination with ...
Cancer
Mar 07, 2013 |
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Linagliptin: Once again, no proof of added benefit
Linagliptin (trade name Trajenta) has been approved since August 2011 to improve blood glucose control in adults with type 2 diabetes. The assessment of the new dossier according to the German Act on the Reform of the Market ...
Medications
Jan 30, 2013 |
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Perampanel for epilepsy: No proof of added benefit
The drug perampanel (trade name Fycompa) has been approved since July 2012 as adjunctive ("add-on") therapy for adults and children aged 12 years and older with epileptic fits (seizures). In an early benefit assessment according ...
Medications
Jan 30, 2013 |
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Added benefit of aclidinium bromide is not proven
The drug aclidinium bromide (trade names Eklira, Bretaris) has been approved since October 2012 for widening the narrowed airways of adults with chronic-obstructive pulmonary disease (COPD). The German Institute for Quality ...
Medications
Jan 30, 2013 |
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Indication of considerable added benefit of vemurafenib in advanced melanoma
Vemurafenib has been approved since February 2012 for the treatment of certain groups of adults with advanced melanoma. The drug offers major advantages in terms of survival, but also causes major side effects. Overall, there ...
Cancer
Jan 08, 2013 |
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Tiotropium has advantages for patients with COPD
In order to widen the narrowed airways in patients with chronic obstructive pulmonary disease (COPD), tiotropium bromide (tiotropium in brief) is one of the drugs available that can be prescribed for inhalation. The German ...
Diseases, Conditions, Syndromes
Dec 11, 2012 |
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Benefit of PET or PET/CT in recurrent bowel cancer is not proven
For patients in whom a recurrence of bowel cancer is suspected, the study data currently available allow no robust conclusions as to the advantages and disadvantages of using positron emission tomography (PET), alone or in ...
Cancer
Dec 10, 2012 |
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Risk of myocardial infarction and re-operation is greater than for drug-coated stents
If narrowed or blocked coronary vessels have to be widened or opened, a vascular support (stent) is usually inserted. Drug-coated stents are preferred for patients at high risk of renewed narrowing of vessels (restenosis). ...
Cardiology
Nov 14, 2012 |
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Vandetanib in thyroid cancer: No proof of added benefit
Vandetanib (trade name Caprelsa) has been approved in Germany since February 2012 for adult patients suffering from a particular form of aggressive thyroid cancer. The German Institute for Quality and Efficiency in Health ...
Cancer
Nov 09, 2012 |
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Belatacept after a kidney transplant: Minor added benefit for certain patients
Belatacept (trade name Nulojix) has been approved since June 2011 to prevent a rejection reaction of the body to the donor organ (transplant) in adults who have received a kidney transplant. The Institute for Quality and ...
Medications
Nov 09, 2012 |
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Considerable added benefit of ipilimumab in advanced melanoma
The humanized antibody ipilimumab (trade name Yervoy) has been approved since August 2011 for the treatment of adult patients with advanced melanoma (black skin cancer) who have already been treated. The term "advanced" means ...
Cancer
Nov 09, 2012 |
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Proof of added benefit of apixaban in hip replacement
The clot-inhibiting drug apixaban (trade name: Eliquis) was approved in May 2011 for the prevention of thrombosis (blood clots) after operations to replace a hip or knee joint. In an early benefit assessment pursuant to the ...
Medications
Sep 17, 2012 |
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Tafamidis: Approval denotes proven added benefit
Tafamidis meglumine (trade name: Vyndaqel) was approved in November 2011 for the treatment of transthyretin amyloidosis in adults. This rare disorder ("orphan disease") is caused by a defective gene and is associated with ...
Medications
Sep 17, 2012 |
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Added benefit of Cannabis sativa for spasticity due to multiple sclerosis is not proven
An extract from the plant Cannabis sativa (trade name Sativex) was approved in May 2011 for patients suffering from moderate to severe spastic paralysis and muscle spasms due to multiple sclerosis (MS). In an early benefi ...
Medications
Sep 17, 2012 |
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