Journal of Clinical Investigation

Oncology & Cancer

Histone deacetylase 6 inhibition enhances oncolytic viral therapy

Gliomas are extremely aggressive brain tumors that are resistant to standard cancer therapeutics. Oncolytic viral (OV) therapy, which uses engineered viruses to infect and target tumor cells for destruction by the immune ...

Diseases, Conditions, Syndromes

A specially tailored gut microbiome alleviates hyperammonemia in mice

The microbiome of the human intestine consists of a variety of bacteria that assist in digestion, immune regulation, and other processes that are critical for human health. A subset of these bacteria produces urease, an enzyme ...

HIV & AIDS

'Redesigned' antibodies may control HIV

With the help of a computer program called "Rosetta," researchers at Vanderbilt University have "redesigned" an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency ...

Diseases, Conditions, Syndromes

Group B Streptococcus breaches the blood-brain-barrier

Bacterial meningitis is a life-threating infection of the central nervous system. Group B Streptococcus (GBS) is the leading cause of meningitis in newborn babies and can cause severe complications in those that survive the ...

HIV & AIDS

Identification of drug combinations that reverse HIV-1 latency

There are almost 40 million people throughout the world living with HIV-1/AIDs. While current antiretroviral therapies are able to reduce the amount of virus in the blood, HIV remains present in a latent state within T cells. ...

Oncology & Cancer

Metabolic compensation underlies drug resistance in glioblastoma

Gliobststoma (GBM) is a highly aggressive brain tumor that is resistant to many conventional cancer therapies. The kinase mTOR induces pathways that are aberrantly activated in GBM. However, mTOR inhibitors have not shown ...

Genetics

Insulin resistance linked to a human gene variant

Insulin resistance is a risk factor for developing both type 2 diabetes and cardiovascular disease. Almost one third of the U.S. population has some degree of insulin resistance, though it is undiagnosed in many of these ...

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