As obesity rates rise, so does the incidence of type 2 diabetes (T2D). In obese individuals and those with obesity-induced T2D, there is an accumulation of immune cells within adipose tissue that results in a low level of ...
Mar 9, 2015
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Hematopoietic stem cells (HSCs) can differentiate into all of the different types of cells that comprise the blood and immune cell lineages. HSC transplantation is the only effective treatment for certain blood disorders; ...
Feb 9, 2015
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Type 1 diabetes is characterized by death and reduced function of β cells, which produce insulin. The presence of specific autoantibodies can identify individuals at risk of developing type 1 diabetes, and many of these ...
Feb 2, 2015
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National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping ...
Jan 20, 2015
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The majority of lung cancers are classified as non-small cell lung cancer (NSCLC). Even with early detection, the 5-year survival rate for patients with NSCLC is less that 50%. Compared to the surrounding tissue, cancer cells ...
Jan 20, 2015
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Sepsis is a leading cause of death for patients in intensive care units. The excessive systemic inflammation in individuals with sepsis damages organs and can lead to death. Therapeutic options for sepsis are limited and ...
Jan 9, 2015
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Alzheimer's disease (AD) is the most common form of dementia and is characterized by the formation of β-amyloid plaques throughout the brain. Proteins known as chemokines regulate inflammation and the immune response. In ...
Dec 15, 2014
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Patients with plasma cell dyscrasis have high amounts of an abnormal immunoglobulin, called a paraprotein, in their blood. While many patients have no outward symptoms, paraproteins can impair immune function, thicken blood, ...
Dec 8, 2014
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Premature ovarian failure (POF) is estimated to affect 1-4% of the female population. Women with POF can present with a variety of symptoms and many genes have been linked to this condition.
Dec 1, 2014
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Ewing sarcoma is a cancer of bone or its surrounding soft tissue that primarily affects children and young adults. A hallmark of Ewing sarcoma is a translocation event that results in the fusion of an RNA binding protein, ...
Nov 17, 2014
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