Journal of Clinical Investigation

A noncoding RNA promotes pediatric bone cancer

Ewing sarcoma is a cancer of bone or its surrounding soft tissue that primarily affects children and young adults. A hallmark of Ewing sarcoma is a translocation event that results in the fusion of an RNA binding protein, ...

Nov 17, 2014
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Food allergy development linked to skin exposure

Food allergies are on the rise in the U.S. and other developed countries. In patients, food allergies appear as a variety of symptoms, ranging from mild skin inflammation to severe asthma. Recent studies suggest that contact ...

Nov 03, 2014
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Liver tropism is key for B cell deletion immunotherapy

Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...

Nov 01, 2013
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Tipping the balance between senescence and proliferation

An arrest in cell proliferation, also referred to as cellular senescence, occurs as a natural result of aging and in response to cellular stress. Senescent cells accumulate with age and are associated with many aging phenotypes, ...

Nov 15, 2013
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