Journal of Clinical Investigation

Diseases, Conditions, Syndromes

Transmission of hepatitis C virus following antiviral treatment

Millions of people throughout the world are infected with hepatitis C virus (HCV). Left untreated, infection results in serious complications such as cirrhosis of the liver and cancer. Many HCV-infected patients respond well ...

Diseases, Conditions, Syndromes

Predicting the outcome of hepatitis C virus treatment

Millions of people throughout the world are infected with hepatitis C virus (HCV), which can lead to cirrhosis of the liver and cancer. Directly acting antiviral agents inhibit viral proteins and have been used to successfully ...

Medical research

Engineered bacteria keep mice lean

Obesity levels are rising throughout the world. As obesity rates increase, so do the incidences of diabetes, heart disease, and other serious health conditions.

Medical research

Role reversal: Linking a reproductive pathway to obesity

People and mice with mutations in a specific signaling pathway, known as kisspeptin, suffer reproductive effects such as delayed puberty and infertility. Research of this pathway has focused on its role in reproduction, but ...

Medical research

Targeting a cell cycle inhibitor promotes beta cell replication

Researchers replicated human pancreatic beta cells—which produce insulin—in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological ...

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