Journal of Clinical Investigation

Immunology

Food allergy development linked to skin exposure

Food allergies are on the rise in the U.S. and other developed countries. In patients, food allergies appear as a variety of symptoms, ranging from mild skin inflammation to severe asthma. Recent studies suggest that contact ...

Alzheimer's disease & dementia

Targeting inflammatory pathway reduces Alzheimer's disease in mice

Alzheimer's disease (AD) is the most common form of dementia and is characterized by the formation of β-amyloid plaques throughout the brain. Proteins known as chemokines regulate inflammation and the immune response. In ...

Diabetes

A link between zinc transport and diabetes

Individuals with a mutation in the gene encoding a zinc transporter, SLC30A8 have an elevated risk of developing type 2 diabetes. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, ...

Inflammatory disorders

Alterations in fatty acid synthesis linked to sepsis inflammation

Sepsis is a leading cause of death for patients in intensive care units. The excessive systemic inflammation in individuals with sepsis damages organs and can lead to death. Therapeutic options for sepsis are limited and ...

Oncology & Cancer

Mesothelial cells promote ovarian cancer metastasis

Less than half of the women diagnosed with ovarian cancer will survive beyond 5 years. Ovarian cancer readily spreads to abdominal organs, which are covered by a layer of cells called the mesothelium. Ovarian cancer cells ...

Cardiology

An autoimmune response may contribute to hypertension

High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease. Inflammation is thought to promote the development of high blood pressure, though it is not clear what triggers ...

Medical research

Pulmonary fibrosis: Between a ROCK and a hard place

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, ...

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