Journal of Clinical Investigation

Parkinson's & Movement disorders

Generating dopamine via cell therapy for Parkinson's disease

In Parkinson's disease, the loss of dopamine-producing cells in the midbrain causes well-characterized motor symptoms. Though embryonic stem cells could potentially be used to replace dopaminergic (DA) neurons in Parkinson's ...

Parkinson's & Movement disorders

Diabetes drug tested in Parkinson's disease patients

Parkinson's disease (PD) is a degenerative neurological disorder marked by a progressive loss of motor control. Despite intensive research, there are currently no approved therapies that have been demonstrated to alter the ...

HIV & AIDS

'Redesigned' antibodies may control HIV

With the help of a computer program called "Rosetta," researchers at Vanderbilt University have "redesigned" an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency ...

Diseases, Conditions, Syndromes

Improving human immunity to malaria

The deadliest form of malaria is caused the protozoan Plasmodium falciparum. During its life-cycle in human blood, the parasite P. falciparum expresses unique proteins on the surface on infected blood cells.

Medical research

No rebirth for insulin secreting pancreatic beta cells

Pancreatic beta cells store and release insulin, the hormone responsible for stimulating cells to convert glucose to energy. The number of beta cells in the pancreas increases in response to greater demand for insulin or ...

Oncology & Cancer

Prostate cancer cells thrive on stress

Not surprisingly, a cancer diagnosis creates stress. And patients with prostate cancer show higher levels of anxiety compared to other cancer patients.

Diabetes

A link between type 2 diabetes and mitochondrial function

Type 2 diabetes is a chronic condition that is characterized by resistance to or insufficient production of insulin, a hormone that controls sugar movement into cells. In certain tissues, insulin resistance has been associated ...

Diseases, Conditions, Syndromes

Transmission of hepatitis C virus following antiviral treatment

Millions of people throughout the world are infected with hepatitis C virus (HCV). Left untreated, infection results in serious complications such as cirrhosis of the liver and cancer. Many HCV-infected patients respond well ...

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