Ludwig Institute for Cancer Research
Mapping the embryonic epigenome
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human ...
Genetics
May 09, 2013 |
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New study reveals how tumor suppressor p53 shut down in metastatic melanoma
Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong. One protein that keeps healthy cells from behaving this way ...
Cancer
Apr 25, 2013 |
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A hijacking of healthy cellular circuits
Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor (EGFR), ...
Cancer
Apr 08, 2013 |
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Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell ...
Cancer
Feb 26, 2013 |
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Epigenetic marker 5hmC opens door to studying its role in developmental disorders and disease
Nearly every cell in the human body carries a copy of the full human genome. So how is it that the cells that detect light in the human eye are so different from those of, say, the beating heart or the spleen?
Genetics
Feb 04, 2013 |
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How the tilt of a cell-surface receptor prevents cancer
Clear communication between cells is essential to every aspect of the body's internal function. But since cells can't talk, or send emails, how do they communicate?
Cancer
Jan 31, 2013 |
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Predictors of cancer disease progression improve patient selection for metastasis-directed therapy
Tumor metastasis, the ability of cancer cells to migrate from their tissue of origin and colonize elsewhere in the body, accounts for over 90% of cancer deaths. When patients die from cancer, it is usually caused by distant ...
Cancer
Dec 11, 2012 |
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Mouse model exposes a new type of T cell to target melanoma
Cancers arise in the body all the time. Most are nipped in the bud by the immune response, not least by its T cells, which detect telltale molecular markers—or antigens—on cancer cells and destroy them before they grow ...
Cancer
Oct 24, 2012 |
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Study uncovers mechanism by which tumor suppressor MIG6 triggers cell suicide
Death plays a big role in keeping things alive. Consider the tightly orchestrated suicide of cells—a phenomenon essential to everything from shaping an embryo to keeping it free of cancer later in life. ...
Cancer
Sep 24, 2012 |
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Modification of tumor suppressor affects sensitivity to potential GBM treatment
Despite years of research, glioblastoma, the most common and deadly brain cancer in adults, continues to outsmart treatments targeted to inhibit tumor growth.
Cancer
Aug 13, 2012 |
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Molecular switch identified that controls key cellular process
The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.
Medical research
Aug 01, 2012 |
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