RIKEN

Oncology & Cancer

Vitamin A derivative selectively kills liver cancer stem cells

Acyclic retinoid, an artificial compound derived from vitamin A, has been found to prevent the recurrence of hepatocellular carcinoma (HCC), the most common form of liver cancer. Now, in research published in Proceedings ...

Neuroscience

The brain's GPS has a buddy system

To be successful as a social animal, you need to know where you stand relative to others. Brain cells that perform precisely this function—locating the 'self' and others in space—have now been identified. In rats, the ...

Neuroscience

What's that smell? The advantage of sniffing

Researchers led by Takeshi Imai at the RIKEN Center for Developmental Biology (CDB) have discovered how the physical and sensory perceptions associated with sniffing are kept separate and why sniffing can help identify odors, ...

Neuroscience

Elementary neural processing units that tile the mouse brain

A hexagonal lattice organizes major cell types in the cerebral cortex, researchers in Japan have discovered. The pattern repeats across the brain, with similar cells synchronizing their activity in 'microcolumns', which could ...

Oncology & Cancer

Blocking key pathways is a way to defeat cancer stem cells

Scientists from the RIKEN Center for Integrative Medical Sciences in Japan and international collaborators have found that in humanized mice, a cocktail of drugs blocking certain key pathways is effective in eliminating acute ...

Immunology

Activation of immune T cells leads to behavioral changes

Scientists from the RIKEN Center for Integrative Medical Sciences in Japan and collaborators have found that T cells—immune cells that help to protect the body from infections and cancer—change the body's metabolism when ...

Neuroscience

Learning and unlearning to fear: The two faces of noradrenaline

Emotional learning can create strong memories and powerful emotional responses, but flexible behavior demands that these responses be inhibited when they are no longer appropriate. Scientists at the RIKEN Brain Science Institute ...

Neuroscience

Superfly flight simulator helps unravel navigation in the brain

Researchers at the RIKEN Brain Science Institute in Japan have identified two independent pathways in the fly brain that are integrated to allow successful navigation during flight. Published in Nature Neuroscience, the study ...

Neuroscience

Serotonin improves sociability in mouse model of autism

Scientists at the RIKEN Brain Science Institute (BSI) in Japan have linked early serotonin deficiency to several symptoms that occur in autism spectrum disorder (ASD). Published in Science Advances, the study examined serotonin ...

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