Protease-activated receptors (PARs) are a family of G-protein-coupled receptors that are primarily expressed in cells of the vasculature and known for their involvement in regulation of vascular tone. These receptors induce ...
Mar 31, 2016
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In a study in the February 2016 Issue (241:3) of Experimental Biology and Medicine researchers at The Pennsylvania State University College of Medicine, led by Dr. Pat McLaughlin, discovered that a novel biological pathway, ...
Feb 29, 2016
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Subcutaneous insulin infusion (CSII) is the gold standard for type 1 diabetic patient therapy. Less physiological than intraperitoneal administration, the subcutaneous route may induce glycemic variability in some patients, ...
Feb 29, 2016
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The human body critically depends on the liver to metabolize toxins and synthesize biomolecules necessary for life. In addition to being a site for life threatening diseases, the liver is particularly sensitive to damage ...
Feb 29, 2016
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The post-translational addition of ubiquitin to proteins by enzymes of the E3 ubiquitin ligase family is largely recognized as a means to target misfolded or unwanted proteins for degradation by the proteasome. However, it ...
Feb 29, 2016
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Pulmonary hypertension is an umbrella term used for many conditions that all result in elevation of the pulmonary arterial pressure. Of interest, many of these completely different clinical and pathophysiological entities ...
Dec 9, 2015
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The role of FIH-1 in the regulation of HIF-1 transcriptional activity has been known for some time, but is limited to the understanding that in the nucleus FIH-1 hydrolyzes asparagine at the C-terminus of HIF-1α to prevent ...
Oct 31, 2015
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Cardiovascular diseases are globally the main cause of death and vascular tissue integrity is important for the proper functionality and homeostasis of the blood system. Therefore, a profound understanding of vascular cell ...
Oct 19, 2015
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Osteoarthritis (OA) is one of the most common age-related degenerative joint concerns. Although articular cartilage degradation is its main feature, this disease induces whole-joint damage characterized by synovitis, bone ...
Jul 15, 2015
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University Medicine Berlin, Department for General, Visceral and Transplantation Surgery, led by Dr. Georg Damm (and Prof. Dr. Daniel Seehofer) have established a protocol for an uncomplicated isolation of primary human hepatocytes ...
Jun 17, 2015
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