St. Jude Children's Research Hospital

Genetics

Upgraded computational tool gets more out of multi-omics data

Despite the astounding advances made in understanding the biologic underpinnings of cancer, many cancers are missing obvious genetic drivers. When scientists can't pinpoint the factors that drive cancer, treating it can be ...

Oncology & Cancer

Combination therapy overcomes BET inhibitor resistance, shows study

Scientists at St. Jude Children's Research Hospital developed a novel combination therapy approach for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer's drug resistance, without ...

Oncology & Cancer

Tool targets cancer-causing fusions' weak spot

Scientists at St. Jude Children's Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.

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