University of Pennsylvania School of Medicine
Research identifies inhibitor causing male pattern baldness and target for hair-loss treatments
Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified an abnormal amount a protein called Prostaglandin D2 in the bald scalp of men with male pattern baldness, a discovery that ...
Medical research
Mar 21, 2012 |
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It's not just what you eat, but when you eat it
Fat cells store excess energy and signal these levels to the brain. In a new study this week in Nature Medicine, Georgios Paschos PhD, a research associate in the lab of Garret FitzGerald, MD, FRS direct ...
Medical research
Nov 11, 2012 |
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A change of heart: Researchers reprogram brain cells to become heart cells
For the past decade, researchers have tried to reprogram the identity of all kinds of cell types. Heart cells are one of the most sought-after cells in regenerative medicine because researchers anticipate ...
Medical research
Jul 08, 2011 |
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New universal platform for cancer immunotherapy developed
(Medical Xpress) -- Researchers from the Perelman School of Medicine at the University of Pennsylvania report this month in Cancer Research a universal approach to personalized cancer therapy based on T c ...
Cancer
Mar 05, 2012 |
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Reprogramming cells to fight diabetes
For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells ...
Medical research
Feb 22, 2013 |
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Engineered T cells kill tumors but spare normal tissue in an animal model
The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal ...
Cancer
Apr 07, 2013 |
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New study explains duality of longevity drug rapamycin
A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend ...
Medical research
Mar 29, 2012 |
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Parkinson's disease protein causes disease spread and neuron death in healthy animals
Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. ...
Parkinson's & Movement disorders
Nov 15, 2012 |
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Study links schizophrenia genetics to disruption in how brain processes sound
(Medical Xpress) -- Recent studies have identified many genes that may put people with schizophrenia at risk for the disease. But, what links genetic differences to changes in altered brain activity in schizophrenia ...
Medical research
Oct 10, 2011 |
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Inner weapons against allergies: Gut bacteria control allergic diseases
When poet Walt Whitman wrote that we "contain multitudes," he was speaking metaphorically, but he was correct in the literal sense. Every human being carries over 100 trillion individual bacterial cells within ...
Immunology
Mar 25, 2012 |
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Four-week vaccination regimen knocks out early breast cancer tumors, researchers find
Researchers at the Perelman School of Medicine at the University of Pennsylvania report that a short course of vaccination with an anti-HER2 dendritic cell vaccine made partly from the patient's own cells triggers a complete ...
Cancer
Jan 30, 2012 |
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Tension on gut muscles induces cell invasion in zebrafish intestine, mimicking cancer metastasis
The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering ...
Cancer
Sep 07, 2012 |
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T-cell therapy eradicates an aggressive leukemia in two children
Two children with an aggressive form of childhood leukemia had a complete remission of their disease-showing no evidence of cancer cells in their bodies-after treatment with a novel cell therapy that reprogrammed their immune ...
Cancer
Mar 25, 2013 |
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New study cautions use of drugs to block 'niacin flush'
Niacin, or vitamin B3, is the one approved drug that elevates "good" cholesterol (high density lipoprotein, HDL) while depressing "bad" cholesterol (low density lipoprotein , LDL), and has thereby attracted much attention ...
Medical research
Apr 09, 2012 |
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Researchers identify a target that could combat allergies of early childhood
A pandemic of ailments called the "allergic march" -- the gradual acquisition of overlapping allergic diseases that commonly begins in early childhood -- has frustrated both parents and physicians. For the ...
Medical research
Aug 14, 2011 |
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