University of Pennsylvania School of Medicine
Study finds four new genetic risk factors for testicular cancer
A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from ...
Genetics
May 12, 2013 |
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Itching for new help for eczema: Recently identified immune cells possible therapeutic target
Researchers have identified a previously unknown critical role for a recently identified immune cell population in the progression of atopic dermatitis. The team found an accumulation of innate lymphoid cells ...
Immunology
Jan 30, 2013 |
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Transmission of tangles in Alzheimer's mice provides more authentic model of tau pathology
Brain diseases associated with the misformed protein tau, including Alzheimer's disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised ...
Neuroscience
Jan 15, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Study: Most-used diabetes drug works in different way than previously thought
A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University ...
Diabetes
Jan 06, 2013 |
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Immune system changes may drive aggressiveness of recurrent tumors
Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The ...
Cancer
Dec 27, 2012 |
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Resistance to cocaine addiction may be passed down from father to son, study shows
Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, ...
Neuroscience
Dec 16, 2012 |
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Parkinson's disease protein causes disease spread and neuron death in healthy animals
Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. ...
Parkinson's & Movement disorders
Nov 15, 2012 |
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It's not just what you eat, but when you eat it
Fat cells store excess energy and signal these levels to the brain. In a new study this week in Nature Medicine, Georgios Paschos PhD, a research associate in the lab of Garret FitzGerald, MD, FRS direct ...
Medical research
Nov 11, 2012 |
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Good bugs gone bad: Gut immune cells keep beneficial microbes in their place
The healthy human intestine is colonized with over 100 trillion beneficial, or commensal, bacteria of many different species. In healthy people, these bacteria are limited to the intestinal tissues and have ...
Medical research
Jun 06, 2012 |
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Block its recycling system, and cancer kicks the can: study
All cells have the ability to recycle unwanted or damaged proteins and reuse the building blocks as food. But cancer cells have ramped up the system, called autophagy, and rely on it to escape damage in the face of chemotherapy ...
Cancer
May 08, 2012 |
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Cardiovascular disease linked to evolutionary changes that may have protected early mammals from trauma
(Medical Xpress) -- Can a bird have a heart attack? A recent paper published by researchers at the Perelman School of Medicine at the University of Pennsylvania suggests that cardiovascular disease may ...
Medical research
Oct 18, 2011 |
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Newly described type of immune cell and T cells share similar path to maturity, according to new study
(Medical Xpress)—Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells (ILCs). Some researchers liken them to foot soldiers that ...
Immunology
May 14, 2013 |
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Not all cytokine-producing cells start out the same way, study finds
(Medical Xpress)—Cytokines are molecules produced by immune cells that induce the migration of other cells to sites of infection or injury, promote the production of anti-microbial agents, and signal the production of inflammatory ...
Immunology
May 13, 2013 |
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Mutation causing wrong-way plumbing explains one type of blue-baby syndrome
Total anomalous pulmonary venous connection (TAPVC), one type of "blue baby" syndrome, is a potentially deadly congenital disorder that occurs when pulmonary veins don't connect normally to the left atrium of the heart. This ...
Medical research
May 12, 2013 |
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