Washington University School of Medicine

Neuroscience

Tau-based biomarker tracks Alzheimer's progression

Two pathologies drive the progression of Alzheimer's disease. Early on, amyloid beta plaques lead the way, but around the time cognitive symptoms arise, tau tangles take over as the driving force and cognition steadily declines. ...

Alzheimer's disease & dementia

Altered gut bacteria may be early sign of Alzheimer's disease

People in the earliest stage of Alzheimer's disease—after brain changes have begun but before cognitive symptoms become apparent—harbor an assortment of bacteria in their intestines that differs from the gut bacteria ...

Medical research

Discovery suggests route to safer pain medications

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. For decades, scientists have attempted to develop drugs that selectively activate one type of opioid receptor ...

Alzheimer's disease & dementia

Sleeping pill found to reduce levels of Alzheimer's proteins

Sleep disturbances can be an early sign of Alzheimer's disease. Many people eventually diagnosed with Alzheimer's start experiencing difficulty falling and staying asleep years before cognitive problems such as memory loss ...

Immunology

Keeping COVID-19 in check will likely require periodic boosters

Between natural infection and a global vaccination campaign, most people now have some immunity against the virus that causes COVID-19. This widespread immunity hasn't stopped people from getting infected, but it has dampened ...

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