Wellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute was formed in 1992 for the purposes of funding biomedical research. Specifically genome sequencing efforts. It is the largest charity in the U.K., and receives a majority of its funds from the Wellcome Trust. The Institute is responsible for the completion of the sequencing of approximately 1/3 of the human genome and model genomes of the mouse and zebrafish and more than 90 pathogen genomes. Today, the Wellcome Trust Sanger Institute has been able to attract top scientists and has more than 30 Senior Researchers on staff. The Institute is located in Hinxton, Cambridge, U.K., and spends approximately 650 British Pounds annually to support relevant research by preeminent scientists and labs around the globe. The Institute supports work at the University of Nottingham, MIT, University of Toronto, University of Gothenburg, University of Manchester and other institutions of higher learning research labs.
Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases
For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments.
Genetics
Apr 21, 2013 |
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Evolving genes lead to evolving genes
Researchers have designed a method that can universally test for evolutionary adaption, or positive (Darwinian) selection, in any chosen set of genes, using re-sequencing data such as that generated by the 1000 Genomes Project. ...
Genetics
Apr 18, 2013 |
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Examining function of all genes in the zebrafish genome to benefit human health
Equipped with the zebrafish genome, researchers have designed a method to assay the function of each and every gene and to explore the effects genetic variation has on zebrafish. So far the team has generated one or more ...
Genetics
Apr 17, 2013 |
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Completion of the zebrafish reference genome yields strong comparisons with the human genome
Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. ...
Genetics
Apr 17, 2013 |
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One step closer to understanding biology behind genetic variants linked to blood cell traits
(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute and University of Cambridge have unpicked genetic variants that affect the formation of blood cells. They found that around a third of ...
Genetics
Apr 17, 2013 |
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Final chapter to 60-year-old blood group mystery
Researchers have solved a 60-year-old mystery by identifying a gene that can cause rejection, kidney failure and even death in some blood transfusion patients. In this study, published in Nature Genetics online ...
Genetics
Apr 07, 2013 |
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Genome wide study identifies genetic variants associated with childhood obesity
Researchers have identified four genes newly associated with severe childhood obesity. They also found an increased burden of rare structural variations in severely obese children.
Genetics
Apr 07, 2013 |
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Tapeworm DNA contains drug weak spots
For the first time, researchers have mapped the genomes of tapeworms to reveal potential drug targets on which existing drugs could act. The genomes provide a new resource that offers faster ways to develop urgently needed ...
Diseases, Conditions, Syndromes
Mar 13, 2013 |
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Computer model helps researchers hunt out cancer-causing mutational signatures in the genome
(Medical Xpress)—Researchers from the Wellcome Trust Sanger Institute's cancer genome project have developed a computer model to identify the fingerprints of DNA-damaging processes that drive cancer development. ...
Genetics
Jan 11, 2013 |
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Influenza virus: Being the most beneficial mutation is no guarantee of long-term genetic success, research finds
(Medical Xpress)—Wellcome Trust Sanger Institute scientists have used computer modelling to understand why some mutations in a virus gene rise to dominance and become 'fixed' in the genome of the virus, ...
Diseases, Conditions, Syndromes
Jan 03, 2013 |
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Gene knockout stops immune cell development
(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute have identified the key gene in ensuring that our immune defences develop infection-fighting cells. No cells of the adaptive immune system ...
Immunology
Dec 11, 2012 |
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Bugs without borders: Researchers track the emergence and global spread of healthcare associated Clostridium difficile
Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to mid-2000s was caused by the spread of two different but highly related strains of the bacterium rather than one as was previo ...
Genetics
Dec 09, 2012 |
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Researchers produce a catalog of the deleterious and disease-causing genetic variants in healthy people
Researchers at Cambridge and Cardiff have found that, on average, a normal healthy person carries approximately 400 potentially damaging DNA variants and two variants known to be associated directly with disease traits. They ...
Genetics
Dec 06, 2012 |
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Study identifies 75 genetic regions that influence red blood cell formation
New research is revealing how red blood cells are made and how the body regulates the amount of haemoglobin that is packaged in red blood cells at any time. Genomic analysis techniques have doubled the number of genetic regions ...
Genetics
Dec 05, 2012 |
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Insights into the genetic causes of coronary artery disease and heart attacks
In the largest genetic study of Coronary Artery Disease (CAD) to date, researchers from the CARDIoGRAMplusC4D Consortium report the identification of 15 genetic regions newly associated with the disease, bringing to 46 the ...
Genetics
Dec 02, 2012 |
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