Wellcome Trust Sanger Institute
Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases
For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments.
Genetics
Apr 21, 2013 |
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Final chapter to 60-year-old blood group mystery
Researchers have solved a 60-year-old mystery by identifying a gene that can cause rejection, kidney failure and even death in some blood transfusion patients. In this study, published in Nature Genetics online ...
Genetics
Apr 07, 2013 |
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Genome wide study identifies genetic variants associated with childhood obesity
Researchers have identified four genes newly associated with severe childhood obesity. They also found an increased burden of rare structural variations in severely obese children.
Genetics
Apr 07, 2013 |
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Influenza virus: Being the most beneficial mutation is no guarantee of long-term genetic success, research finds
(Medical Xpress)—Wellcome Trust Sanger Institute scientists have used computer modelling to understand why some mutations in a virus gene rise to dominance and become 'fixed' in the genome of the virus, ...
Diseases, Conditions, Syndromes
Jan 03, 2013 |
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Bugs without borders: Researchers track the emergence and global spread of healthcare associated Clostridium difficile
Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to mid-2000s was caused by the spread of two different but highly related strains of the bacterium rather than one as was previo ...
Genetics
Dec 09, 2012 |
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Study identifies 75 genetic regions that influence red blood cell formation
New research is revealing how red blood cells are made and how the body regulates the amount of haemoglobin that is packaged in red blood cells at any time. Genomic analysis techniques have doubled the number of genetic regions ...
Genetics
Dec 05, 2012 |
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New invasive non-Typhoidal Salmonella epidemic identified in sub-Saharan Africa
(Medical Xpress)—A new study out today reveals that the emergence and spread of a rapidly evolving invasive intestinal disease, that has a significant mortality rate (up to 45%) in infected people in sub-Saharan ...
Genetics
Sep 30, 2012 |
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Researchers announce the first comprehensive genome studies of the evolution of 21 breast cancers
In two back-to-back reports published online on 17 May in Cell, researchers have sequenced the genomes of 21 breast cancers and analysed the mutations that emerged during the tumours' development. The individual results are de ...
Cancer
May 17, 2012 |
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Landscape of cancer genes and mutational processes in breast cancer
In a study published today in Nature, researchers describe nine new genes that drive the development of breast cancer. This takes the tally of all genes associated with breast cancer development to 40.
Cancer
May 16, 2012 |
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Rare muscular dystrophy gene mutations discovered
(Medical Xpress) -- Research co-led by Radboud University Nijmegen Medical Centre and the Wellcome Trust Sanger Institute has revealed gene mutations that account for 15 per cent of all babies born with Walker-Warburg ...
Genetics
Apr 24, 2012 |
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The path to personalized cancer treatment
In the largest study of its kind, researchers have profiled genetic changes in cancer with drug sensitivity in order to develop a personalised approach to cancer treatments. The study is published in Nature on Thursday 29 Mar ...
Cancer
Mar 28, 2012 |
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Scientists discover elusive platelet count and limb development gene
Researchers have identified an elusive gene responsible for Thrombocytopenia with Absent Radii (TAR), a rare inherited blood and skeletal disorder. As a result, this research is now being transformed into ...
Genetics
Feb 26, 2012 |
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Malaria parasite requires a single receptor to invade human red blood cells
Researchers have today revealed a key discovery in understanding how the most deadly species of malaria parasite, Plasmodium falciparum, invades human red blood cells. Using a technique developed at the Wellcome Trust Sanger ...
Medical research
Nov 09, 2011 |
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New gene therapy methods accurately correct mutation in patient's stem cells
For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported in Nature on Wednesday 12 October, brings the possibility of patient-specific therapies closer to bec ...
Genetics
Oct 12, 2011 |
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Evolving genes lead to evolving genes
Researchers have designed a method that can universally test for evolutionary adaption, or positive (Darwinian) selection, in any chosen set of genes, using re-sequencing data such as that generated by the 1000 Genomes Project. ...
Genetics
Apr 18, 2013 |
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