Obese patients face increased risk of kidney damage after heart surgery

May 24th, 2012 in Diseases, Conditions, Syndromes /

Oxidative stress may put obese patients at increased risk of developing kidney damage after heart surgery, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). Effective antioxidants or other therapies that reduce oxidative stress might help lower this risk, particularly among obese patients.

Acute kidney injury (AKI), an abrupt decline in , is an increasingly prevalent and potentially serious condition following major surgery. Sometimes AKI arises after heart surgery because the kidneys are deprived of normal blood flow during the procedure.

To see if extra body weight puts patients at increased risk for developing AKI following heart surgery, Frederic Billings IV, MD (Vanderbilt University School of Medicine) and his colleagues evaluated information from 445 heart surgery patients, 112 of whom (25%) developed AKI.

Among the major findings:

"The identification of oxidative stress during surgery as a possible mechanism for the development of kidney injury following surgery provides an opportunity to develop and test therapeutic treatments for surgical patients," said Dr. Billings.

More information: The article, entitled "Obesity and Oxidative Stress Predict Acute Kidney Injury Following Cardiac Surgery," will appear online on May 24, 2012, doi: 10.1681/ASN.2011090940

Provided by American Society of Nephrology

"Obese patients face increased risk of kidney damage after heart surgery." May 24th, 2012. http://medicalxpress.com/news/2012-05-obese-patients-kidney-heart-surgery.html