Breast cancer prognosis associated with oncometabolite accumulation

December 9th, 2013 in Cancer /

The metabolic profile of cancer cells can be used to develop therapies and identify biomarkers associated with cancer outcome. In this issue of the Journal of Clinical Investigation Stefan Ambs and colleagues at the National Cancer Institute discovered an association between the oncometabolite 2-hydroxyglutarate (2-HG) levels, DNA methylation patterns, and breast cancer prognosis.

The authors identified a breast cancer subtype with high levels of 2-HG, and a district DNA methylation pattern that was associated with reduced survival.

This breast cancer subtype was common in African-American breast cancer patients, who as a group have a high prevalence of aggressive breast cancers.

This study indicates that evaluation of 2-HG along with DNA methylation may be a useful biomarker for diagnosis and prognosis

More information: MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis, J Clin Invest. DOI: 10.1172/JCI71180

Provided by Journal of Clinical Investigation

"Breast cancer prognosis associated with oncometabolite accumulation." December 9th, 2013. http://medicalxpress.com/news/2013-12-breast-cancer-prognosis-oncometabolite-accumulation.html