http://medicalxpress.com/inflammatory-disorders-news/ en-us Medical Xpress provides the latest research news on inflammatory disorders (Medical Xpress)—Inflammation is an important response in the body - it helps you to kill off invaders such bacteria that could cause a harmful infection. But if it's chronic or uncontrolled, inflammation can also cause trouble in conditions including rheumatoid arthritis, inflammatory bowel disease and a potentially fatal immune reaction to infection called sepsis. http://medicalxpress.com/news/2013-05-inflammation.html Inflammatory disorders Tue, 14 May 2013 09:48:06 EST news287743679 Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque. The findings, made in mice and confirmed with human data, suggest new therapeutic targets for reducing heart disease in people with type 1 diabetes. Led by Columbia University Medical Center (CUMC) researchers in collaboration with investigators at New York University and the University of Pittsburgh, the study was published today in the online edition of Cell Metabolism. http://medicalxpress.com/news/2013-05-diabetes-heart-disease-linked-inflammatory.html Inflammatory disorders Tue, 07 May 2013 12:00:01 EST news287139513 A potential new strategy to developing new drugs to control inflammation without serious side effects has been found by Georgia State University researchers and international colleagues. http://medicalxpress.com/news/2013-04-key-pathway-dangerous-out-of-control-inflammation.html Inflammatory disorders Tue, 09 Apr 2013 16:47:06 EST news284744805 Many recent studies have suggested that obesity is associated with chronic inflammation in fat tissues. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an imbalance between an enzyme called neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. This enzyme is produced by white blood cells called neutrophils, which play an important role in the body's immune defense against bacteria. The researchers found that obese humans and mice have increased neutrophil elastase activity and decreased levels of α1-antitrypsin, a protein that inhibits the elastase. When the team reversed this imbalance in a mouse model and fed them a high-fat diet, the mice were resistant to body weight gain, insulin resistance (a precursor to type 2 diabetes), and fatty liver disease. http://medicalxpress.com/news/2013-04-white-blood-cell-enzyme-contributes.html Inflammatory disorders Tue, 02 Apr 2013 16:16:32 EST news284138185 (Medical Xpress)—New research by Yale University scientists sets the stage for improved management of acute tissue inflammation related to wounds and chronic inflammatory diseases by advancing current understanding of inflammatory processes. http://medicalxpress.com/news/2013-03-inflammation-white-blood-cell-key.html Inflammatory disorders Thu, 28 Mar 2013 07:30:02 EST news283674268 New research from Boston University School of Medicine (BUSM) reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms. The study, published in the Proceedings of the National Academies of Sciences, indicates the importance of continuing to explore B cells as a therapeutic target to treat these diseases. Barbara Nikolajczyk, PhD, associate professor of microbiology at BUSM, is the study's senior author. http://medicalxpress.com/news/2013-03-reveals-therapeutic-inflammation-diabetes.html Inflammatory disorders Tue, 12 Mar 2013 13:19:29 EST news282313161 Scientists from Brigham and Women's Hospital are on the brink of the next treatment advancement that may spell relief for the nearly nineteen million adults and seven million children in the United States suffering from asthma. The scientists discovered two new drug targets in the inflammatory response pathway responsible for asthma attacks. http://medicalxpress.com/news/2013-02-scientists-molecule-duty-asthma.html Inflammatory disorders Wed, 27 Feb 2013 14:00:05 EST news281190194 (Medical Xpress)—Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it. http://medicalxpress.com/news/2013-02-scientists-underlying-mechanisms-chronic-inflammation-associated.html Inflammatory disorders Sat, 23 Feb 2013 06:56:08 EST news280824946 Existing mouse models do not appear to accurately reproduce the human genomic response to serious traumatic injury, including major burns, according to an article appearing in PNAS Early Edition. http://medicalxpress.com/news/2013-02-mouse-inflammatory-genomic-response-injuries.html Inflammatory disorders Mon, 11 Feb 2013 15:00:01 EST news279804831 (Medical Xpress)—Scientists have long puzzled over why "bad" bacteria such as E. coli can thrive in the guts of those with inflammatory bowel disease (IBD), causing serious diarrhea. Now UC Davis researchers have discovered the answer—one that may be the first step toward finding new and better treatments for IBD. http://medicalxpress.com/news/2013-02-scientists-key-growth-bad-bacteria.html Inflammatory disorders Thu, 07 Feb 2013 15:56:09 EST news279474958 (Medical Xpress)—Scientists trying to create drugs to treat chronic inflammation in diseases like arthritis now have a new culprit known MMP2. New University of British Columbia research shows that this enzyme works as a master switch to activate inflammatory diseases. http://medicalxpress.com/news/2013-01-master-discovery-road-treatment-arthritis.html Inflammatory disorders Wed, 23 Jan 2013 07:10:02 EST news278145932 Children who frequently eat fast food are far likelier to have severe asthma compared to counterparts who tuck into fruit, a large international study published on Monday said. http://medicalxpress.com/news/2013-01-fast-food-linked-child-asthma.html Inflammatory disorders Mon, 14 Jan 2013 09:46:19 EST news277379172 (Medical Xpress)—Many illnesses, including psoriasis, include inflammatory responses that occur without an apparent infection and worsen with stress. In a study using cultured human mast cells in vitro and in rats, researchers from Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University identified mitochondrial particles—secreted from live, activated mast cells—as a possible trigger of the inflammation that is common in such illnesses. http://medicalxpress.com/news/2013-01-mitochondrial-components-trigger-auto-inflammatory-illnesses.html Inflammatory disorders Wed, 02 Jan 2013 09:01:05 EST news276339657 (Medical Xpress)—Researchers at Oregon State University today announced the discovery of an underlying genetic cause of atopic dermatitis, a type of eczema most common in infancy that also affects millions of adults around the world with dry, itchy and inflamed skin lesions. http://medicalxpress.com/news/2012-12-genetic-basis-eczema-avenue-therapies.html Inflammatory disorders Fri, 21 Dec 2012 13:14:21 EST news275318051 Scientists at the Stanford University School of Medicine have identified a set of proteins circulating in blood whose levels accurately flag the presence of lymphedema. The findings, to be reported Dec. 18 in PLoS ONE, spur optimism that this common but relatively neglected condition, which affects an estimated 10 million people in the United States, finally will be amenable to detection (and, eventually, treatment) with 21st-century techniques. http://medicalxpress.com/news/2012-12-blood-accurately-lymphedema.html Inflammatory disorders Tue, 18 Dec 2012 17:00:05 EST news275072203 A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune disorders, neurodegenerative diseases, and metabolic diseases such as diabetes. This enzyme, which is known to be responsible for providing cancer cells the endless ability to divide, is now found to also jumpstart and maintain chronic inflammation in cancers. http://medicalxpress.com/news/2012-11-scientists-potential-drug-inflammatory-diseases.html Inflammatory disorders Wed, 21 Nov 2012 08:40:02 EST news272707979 In a discovery that can fundamentally change how drugs for arthritis, and potentially many other diseases, are made, University of Utah medical researchers have identified a way to treat inflammation while potentially minimizing a serious side effect of current medications: the increased risk for infection. http://medicalxpress.com/news/2012-11-discovery-medications-inflammation-infection.html Inflammatory disorders Sun, 11 Nov 2012 13:00:44 EST news271860828 A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment. http://medicalxpress.com/news/2012-10-bacterial-protein-house-spurs-asthma.html Inflammatory disorders Mon, 15 Oct 2012 13:11:47 EST news269525500 (Medical Xpress)—A fundamental mechanism controlling cells of the human immune system could be key to helping fight inflammatory diseases such as rheumatoid arthritis and psoriasis, new research at the University of Dundee has found. http://medicalxpress.com/news/2012-10-immune-cells-inflammatory-diseases.html Inflammatory disorders Thu, 11 Oct 2012 07:34:27 EST news269159658 Magnesium sulfate is given to many pregnant women to treat preterm labor and preeclampsia and was recently shown to prevent cerebral palsy; however little is known about how it works. Researchers at Case Western Reserve University School of Medicine recently discovered the mechanism by which magnesium reduces the production of cytokines. Cytokines are molecules responsible for regulating inflammation; they play a key role conditions, such as diabetes, obesity, atherosclerosis, asthma, and alcoholic liver disease and cirrhosis. Although the study related to pregnancy, inflammation is the culprit of many conditions and learning more about individual's magnesium levels may help a much broader patient population. http://medicalxpress.com/news/2012-10-preterm-labor-powerhouse-therapy-inflammatory.html Inflammatory disorders Tue, 09 Oct 2012 15:43:32 EST news269016204 Scientists from the Florida campus of The Scripps Research Institute have developed a novel technology that can identify, in animal models, potential biomarkers of ulcerative colitis, a type of inflammatory bowel disease that affects the lining of the colon. http://medicalxpress.com/news/2012-10-scientists-technology-biomarkers-ulcerative-colitis.html Inflammatory disorders Wed, 03 Oct 2012 17:23:26 EST news268503798 A simple new test, in which the patient swallows a string, can monitor treatment of eosinophilic esophagitis as effectively as an invasive, expensive and uncomfortable procedure that risks complications, particularly in children. http://medicalxpress.com/news/2012-10-simple-ease-esophagitis.html Inflammatory disorders Wed, 03 Oct 2012 16:02:41 EST news268498953 Researchers have discovered a previously unknown function for a protein that could add to the expanding arsenal of potential new drugs for battling inflammation and tissue fibrosis in a number of disease processes. http://medicalxpress.com/news/2012-09-efforts-effective-anti-inflammatory-drugs.html Inflammatory disorders Thu, 27 Sep 2012 12:00:37 EST news267965288 A research team led by investigators at New York University and NYU School of Medicine has determined how cells that cause inflammatory ailments, such as Crohn's disease, multiple sclerosis, and arthritis, differentiate from stem cells and ultimately affect the clinical outcome of these diseases. http://medicalxpress.com/news/2012-09-inflammatory-cells-function-stage-future.html Inflammatory disorders Wed, 26 Sep 2012 13:24:34 EST news267884658 Research conducted at the University of Southern California (USC) indicates that at least 8 percent of the more than 300,000 cases of childhood asthma in Los Angeles County can be attributed to traffic-related pollution at homes within 75 meters (a little less than 250 feet) of a busy roadway. http://medicalxpress.com/news/2012-09-near-roadway-air-pollution-major-contributor.html Inflammatory disorders Mon, 24 Sep 2012 03:57:45 EST news267677848 Research carried out at The University of Manchester has found further evidence that a simple solution, which is already used in IV drips, is an effective treatment for reducing inflammation. http://medicalxpress.com/news/2012-09-solution-inflammation.html Inflammatory disorders Thu, 20 Sep 2012 10:29:50 EST news267355777 A new study that identifies ways to reduce the factors that lead to an asthma attack gives hope to asthma sufferers. A UCSF researcher and his colleagues believe they have found a way to help asthma sufferers by impeding the two most significant biological responses that lead to an asthma attack. http://medicalxpress.com/news/2012-09-physiological-factors-asthma.html Inflammatory disorders Mon, 17 Sep 2012 16:36:39 EST news267118573 For two decades, asthma treatment for millions of people with a milder form of the disease has consisted of daily inhaled steroid medicine to reduce inflammation. Now, a new study has found that asthmatics who take the low-dose medication as a daily routine do no better than those who turn to their inhalers only when they have symptoms. http://medicalxpress.com/news/2012-09-asthma-big-daily-regimen.html Inflammatory disorders Tue, 11 Sep 2012 16:00:01 EST news266596608 Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes. http://medicalxpress.com/news/2012-08-treatment-diabetes-wolfram-syndrome.html Inflammatory disorders Tue, 07 Aug 2012 12:44:11 EST news263562230 Results from a study conducted at Georgia State University suggest that a "fight" between bacteria normally living in the intestines and the immune system, kicked off by another type of bacteria, may be linked to two types of chronic disease. http://medicalxpress.com/news/2012-08-bacteria-immune-chronic-diseases.html Inflammatory disorders Thu, 02 Aug 2012 13:43:15 EST news263133777