http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Cell Transplantation Center of Excellence for Aging and Brain Repair A team of Korean researchers investigated whether "environmental enrichment" can improve the neurobehavioral function of six week-old mice after transplantation of adipose-derived stem cells (ASCs) to treat hypoxic-ischemic brain injury, and found that brain repair (neurogenesis) was aided in some animals through exercise-induced fibroblast growth factor 2 (FGF2), a strong pro-angiogenic factor. http://medicalxpress.com/news/2013-03-environmental-enrichment-important-factor-impacting.html Medical research Wed, 27 Mar 2013 11:38:43 EST news283603116 When a research team in China evaluated the efficacy and safety of using mesenchymal stem cells (MSCs) expanded from the bone marrow of non-self-donors to treat patients experiencing poor graft function (PGF) after receiving transplants of non-self-donated blood stem cells (allo-HSCT), they found that the mesenchymal stem cells were both safe and effective for treating primary and secondary PGF. http://medicalxpress.com/news/2013-03-third-party-blood-stem-cell-transplantation.html Medical research Mon, 18 Mar 2013 13:43:50 EST news282833021 Researchers at the Johns Hopkins University in Baltimore, Md., and the Mossakowski Medical Research Centre in Warsaw, Poland, have found that nonself-donated cells (allografts) better survive implantation into the brains of immunocompetent research mice when the grafts are injected into the striatum (STR) of the brain rather than injected into the forceps minor (FM) region. In their study, all FM grafts were rejected while STR grafts accumulated and survived along the border between the striatum and the corpus callosum. http://medicalxpress.com/news/2013-02-impact-stem-cell-transplantation-brain.html Medical research Wed, 13 Feb 2013 17:03:35 EST news279997400 When a research team from Denmark and Sweden compared the therapeutic capabilities of adipose-derived stem cells (ASCs) versus bone marrow-derived stem cells (BMSCs) obtained from a single 84 year-old male donor with ischemic coronary disease to regeneratively treat myocardial infarction in a rat model, they found that the ASCs preserved more cardiac function in the test rats while neither stem cell type induced myocardial angiogenesis (blood vessel growth.) http://medicalxpress.com/news/2013-02-stem-cell-source-important-factor.html Medical research Wed, 13 Feb 2013 17:01:59 EST news279997302 When different types of cells are transplanted with the intent of having them aid in repairing central nervous system (CNS) trauma, what is the fate and function of those cells? A Belgian research team carried out research aimed at answering this question by determining how five varieties of cells - neural stem cells, mouse embryonic fibroblasts, dendritic cells, bone marrow mononuclear cells (BMMNCs) and splenocytes - functioned and survived after transplantation in the CNS. http://medicalxpress.com/news/2012-12-fate-function-cells-transplanted-cns.html Medical research Thu, 20 Dec 2012 17:19:57 EST news275246338 Using mesenchymal stromal cells derived from adipose (fat) tissues, genetically modified to express a bioluminescent marker, researchers in Italy have tracked cells after transplantation. The cells were followed from their injection into the spleen of mice modeling liver disease, to their characterization as "hepatic precursors," and to their subsequent migration through the spleen before engrafting at regenerating sites in the liver by bioluminescent imaging. http://medicalxpress.com/news/2012-12-transplanted-genetically-modified-adipose-cells-potential.html Medical research Thu, 20 Dec 2012 16:50:01 EST news275244596 A study published in the current issue of Cell Transplantation (21:8), now freely available on-line, has found that when mesenchymal cells derived from skeletal muscle (SM-MSCs) or adipose tissue (ADSCs) were injected into the heart muscle (myocardium) of separate groups of laboratory rats that had suffered a myocardial infarction, rats in both groups experienced significantly improved left ventricle function and smaller infarct size after cell therapy. http://medicalxpress.com/news/2012-11-organ-derived-stem-cell-heart-function.html Cardiology Tue, 27 Nov 2012 12:18:55 EST news273241126 A study published in the current issue of Cell Transplantation (21:8), now freely available on-line, reports that a team of researchers in South Korea have successfully engineered islet cell clusters (ICCs) that will improve pancreatic islet transplantation and offer promise for curing diabetes mellitus. http://medicalxpress.com/news/2012-11-islet-cell-advancement-impact-transplantation.html Medical research Tue, 27 Nov 2012 11:54:58 EST news273239689 Two studies published in the current issue of Cell Transplantation (21:7), now freely available on-line, investigate the role of oxygen in cell transplantation. http://medicalxpress.com/news/2012-11-oxygen-impact-factor-transplantation.html Medical research Thu, 15 Nov 2012 13:18:52 EST news272207920 In a study to investigate the detection by MRI of six kinds of positively-charged magnetic iron oxide nanoparticles designed to help monitor transplanted islet cells, a team of Japanese researchers found that the charged nanoparticles they developed transduced into cells and could be visualized by MRI while three kinds of commercially available nanoparticles used for controls could not. The study is published in a recent special issue of Cell Medicine [3(1)], now freely available on-line. http://medicalxpress.com/news/2012-10-mri-images-transplanted-islet-cells.html Medical research Mon, 01 Oct 2012 12:02:47 EST news268311760 A research team from Germany has found that optimal benefit and functional improvement for ischemic stroke results when human umbilical cord blood mononuclear cells (hUCB MNCs) are transplanted into rat stroke models within 72 hours of the stroke. Their study is published in the current issue of Cell Transplantation (21:6), now freely available on-line. http://medicalxpress.com/news/2012-10-therapeutic-window-important-factor-cord.html Medical research Mon, 01 Oct 2012 12:01:59 EST news268311707 In a study to determine the best cryopreservation (freezing) solution to maintain induced pluripotent stem (iPS) cells, a team of researchers from Japan compared 12 kinds of commercially prepared and readily available cryopreservation solutions and found that "Cell Banker 3" out-performed the other 11 solutions by allowing iPS cells to be preserved for a year at −80°C degrees C in an undifferentiated state. http://medicalxpress.com/news/2012-09-cryopreservation-pluripotent-stem-cells-product.html Medical research Tue, 25 Sep 2012 17:02:05 EST news267811301 In a study to investigate how transplanted islet cells can differentiate and mature into insulin-producing pancreatic cells, a team of Japanese researchers found that using a specific set of transcription factors (proteins that bind to specific DNA sequences) could be transduced into mouse pancreatic stem cells (mPSCs) using Sendai virus (SeV), a mouse influenza virus, as a carrier, or vector. The study is published in a recent issue of Cell Medicine [3(1)], now freely available on-line. http://medicalxpress.com/news/2012-09-mouse-pancreatic-stem-cells-successfully.html Medical research Tue, 25 Sep 2012 16:58:40 EST news267811105 Two studies in the current issue of Cell Transplantation (21:6), now freely available on-line, demonstrate how the use of magnetic particles are a factor that can positively impact on the targeted delivery of transplanted stem cells and to also provide better cell retention. http://medicalxpress.com/news/2012-09-therapeutic-impact-cell-transplantation-aided.html Medical research Mon, 24 Sep 2012 12:41:19 EST news267709267 A study comparing whether endothelial colony-forming cells (ECFCs) derived from human placenta or those derived from human umbilical cord blood are more proliferative and better for forming new blood vessels has found that ECFCs derived from human placenta are more vasculogenic. http://medicalxpress.com/news/2012-07-blood-vessel-potential-stem-cells.html Medical research Thu, 19 Jul 2012 17:20:07 EST news261937162