http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Fox Chase Cancer Center A common virus known to cause cervical and head and neck cancers may also trigger some cases of lung cancer, according to new research presented by Fox Chase Cancer Center at the AACR Annual Meeting 2013 on Wednesday, April 10. http://medicalxpress.com/news/2013-04-lung-cancers-linked-common-virus.html Cancer Wed, 10 Apr 2013 09:15:43 EST news284804136 A new preclinical technology enables researchers to quickly determine if a particular treatment is effective against gastrointestinal stromal tumors (GISTs), providing a boost to animal research and possibly patient care, according to new findings presented by Fox Chase Cancer Center at the AACR Annual Meeting 2013 on Tuesday, April 9. http://medicalxpress.com/news/2013-04-technology-drugs-early-impact-cancer.html Cancer Tue, 09 Apr 2013 13:00:03 EST news284730684 A variety of mutations may give rise to breast cancer, but scientists generally assume that it starts off with just a few. That's because later-stage breast cancers tend to have more mutations—they are more heterogeneous—than early stage cancers. Now, new findings by scientists at Fox Chase Cancer Center demonstrate heterogeneity is prevalent even within legions of ductal carcinoma in situ (DCIS), the most common, earliest stage non-invasive breast cancer (stage 0). The results, to be presented at the AACR Annual Meeting 2013 on Tuesday, April 9, suggest that a multiple-target approach to diagnosis and therapy may be needed to fight breast cancer from the very start. http://medicalxpress.com/news/2013-04-quantifying-heterogeneity-breast-cancer.html Cancer Tue, 09 Apr 2013 13:00:03 EST news284730723 Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer—one of the least understood groups of breast cancer. These molecules, called metabolites, include key players in energy regulation and lipid synthesis. They could help pave the way for helping researchers differentiate among different forms of the disease and ultimately point to new targets for treatment. http://medicalxpress.com/news/2013-04-critical-metabolic-triple-negative-breast-cancer.html Cancer Tue, 09 Apr 2013 13:00:01 EST news284730706 Researchers from Fox Chase Cancer Center have found that omega-3 fatty acids and their metabolite products slow or stop the proliferation, or growth in the number of cells, of triple-negative breast cancer cells more effectively than cells from luminal types of the disease. The omega-3s worked against all types of cancerous cells, but the effect was observed to be stronger in triple-negative cell lines, reducing proliferation by as much as 90 percent. The findings will be presented at the AACR Annual Meeting 2013 on Tuesday, April 9. http://medicalxpress.com/news/2013-04-omega-fatty-acids-effective-inhibiting.html Cancer Tue, 09 Apr 2013 09:42:43 EST news284719356 A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors, according findings to be presented by Fox Chase Cancer Center researchers at the AACR Annual Meeting 2013 on Tuesday, April 9. http://medicalxpress.com/news/2013-04-treatment-resistant-lung-cancer.html Cancer Tue, 09 Apr 2013 09:40:24 EST news284719217 Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions. The most common type of change is a white patch known as a leukoplakia. Because it often takes decades for leukoplakias to develop into HNSCC, there is a window of opportunity to recognize and revert precancerous changes, thus preventing this type of cancer. http://medicalxpress.com/news/2013-04-drug-neck-cancers.html Cancer Tue, 09 Apr 2013 09:35:39 EST news284718932 Once considered part of the "junk" of our genome, much of the DNA between protein-coding genes is now known to be transcribed. New findings by scientists at Fox Chase Cancer Center have identified several dozen transcripts known as lincRNAs, or long intergenic non-coding RNAs, that are dysregulated in breast cancer. The results, to be presented at the AACR Annual Meeting 2013 on Monday, April 8, offer both a new research path for better understanding of how breast cancer works and a new method for identifying lincRNAs that may contribute to tumorigenesis or regulation of other cancers. http://medicalxpress.com/news/2013-04-exploring-lincrna-role-breast-cancer.html Cancer Mon, 08 Apr 2013 13:00:05 EST news284633278 Women with HIV acquire cancer-causing forms of the human papillomavirus (HPV) that are not included in the current HPV vaccines Gardasil and Cervarix, according to new research from Fox Chase Cancer Center being presented at the AACR Annual Meeting 2013 on Sunday, April 7. http://medicalxpress.com/news/2013-04-current-hpv-vaccine-women-immune.html Cancer Sun, 07 Apr 2013 13:00:32 EST news284554939 Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Once colorectal cancer has spread to other parts of the body, only 11 percent of patients will survive five years from the date of their diagnosis. Most colorectal cancers are adenocarcinomas—cancers that begin in cells that make and release mucus and other fluids. Adenocarcinomas begin as benign tumors called adenomas, which become malignant over time. By treating adenomas before they become cancerous, it could be possible to prevent colorectal cancer. http://medicalxpress.com/news/2013-04-drug-combinations-treatment-colorectal-tumors.html Cancer Sun, 07 Apr 2013 13:00:16 EST news284554964 Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center. The results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the proteins. http://medicalxpress.com/news/2013-02-antagonistic-proteins-leukemia-bay-potential.html Cancer Wed, 27 Feb 2013 16:24:06 EST news281204639 Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue of Cancer Discovery. http://medicalxpress.com/news/2013-01-scientists-boost-common-cancer-drugs.html Cancer Mon, 14 Jan 2013 16:13:04 EST news277402360 Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9—which regulates cell migration, division and survival—has been linked to tumor invasion and metastasis in a variety of cancers. Researchers at Fox Chase Cancer Center have now shown that NEDD9 plays a surprising role in the early stages of breast tumor development by controlling the growth of progenitor cells that give rise to tumors. The findings, published in the journal Oncogene on January 14, 2013, could lead to personalized treatment strategies for women with breast cancer based on the levels of NEDD9 in their tumors. http://medicalxpress.com/news/2013-01-role-nedd9-gene-early-stages.html Cancer Mon, 14 Jan 2013 13:08:36 EST news277391310 Inflammatory breast cancer (IBC) is a very rare and aggressive disease that progresses rapidly and is associated with a very low survival rate. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3D environment. Researchers at Fox Chase Cancer Center have developed a novel, 3D culture system that mimics the environment surrounding these cancer cells. This model could be used to test new anticancer drugs capable of inhibiting the spread of IBC tumors. http://medicalxpress.com/news/2012-12-d-culture-inflammatory-breast-cancer.html Cancer Sun, 09 Dec 2012 02:51:18 EST news274243825 Previous research has shown that a family of genes, proteins and enzymes called the uPA system (for urokinase plasminogen activator) plays an active role in different facets of cancer's biology, including tumor cell invasion, the spread of metastases, and the growth of a primary tumor. Mesupron® is a new small molecule inhibitor, taken as a pill, that inhibits the uPA system. The results from a recent phase II clinical study suggest that the drug could be a safe and first-line treatment that extends progression-free survival for metastatic breast cancer patients, when combined with the chemotherapeutic drug Capecitabine. Results will be presented by Lori J. Goldstein, MD, Director of the Breast Evaluation Center at Fox Chase Cancer Center, at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium on Friday, December 7, 2012. http://medicalxpress.com/news/2012-12-small-molecule-inhibitor-safe-first-line.html Cancer Sat, 08 Dec 2012 02:21:27 EST news274155663