http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Gladstone Institutes Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process. The team further found that disruptions to this process occur in mouse models of Alzheimer's disease—and identified two therapeutic strategies that reduce these disruptions. http://medicalxpress.com/news/2013-03-scientists-dna-brain.html Alzheimer's disease & dementia Sun, 24 Mar 2013 14:10:01 EST news283335265 Scientists at the Gladstone Institutes have mapped the molecular mechanism by which a virus known as cytomegalovirus (CMV) so successfully infects its hosts. This discovery paves the way for new research avenues aimed at fighting this and other seemingly benign viruses that can turn deadly. http://medicalxpress.com/news/2012-12-powerful-infection-strategy-widespread-potentially.html Medical research Thu, 20 Dec 2012 12:00:07 EST news275224813 Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet—called a "ketogenic diet"—could delay the effects of aging. This fundamental discovery reveals how such a diet could slow the aging process and may one day allow scientists to better treat or prevent age-related diseases, including heart disease, Alzheimer's disease and many forms of cancer. http://medicalxpress.com/news/2012-12-gladstone-scientists-mechanism-calorie-restriction.html Medical research Thu, 06 Dec 2012 14:23:32 EST news274026168 Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions—leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that. http://medicalxpress.com/news/2012-12-apoe-ideal-halting-alzheimer-disease.html Alzheimer's disease & dementia Wed, 05 Dec 2012 12:00:06 EST news273925722 The ALS Therapy Development Institute (ALS TDI) and the Gladstone Institutes today announced the formation of a research collaboration to speed the discovery of potential treatments for ALS through the preclinical drug development process. http://medicalxpress.com/news/2012-12-als-tdi-gladstone-collaborate-potential.html Medical research Tue, 04 Dec 2012 10:33:11 EST news273839583 October 28, 2012— Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease)—a fatal disease for which there is no cure. http://medicalxpress.com/news/2012-10-scientists-block-toxic-protein-key.html Medical research Sun, 28 Oct 2012 13:00:01 EST news270630020 Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. These results lay the foundation for therapies that one day may benefit those who suffer from this and related diseases that wreak havoc on the brain. http://medicalxpress.com/news/2012-10-biological-mechanism-key-role-early-onset.html Neuroscience Mon, 08 Oct 2012 12:00:11 EST news268910852 Scientists at the Gladstone Institutes have revealed the precise order and timing of hundreds of genetic "switches" required to construct a fully functional heart from embryonic heart cells—providing new clues into the genetic basis for some forms of congenital heart disease. http://medicalxpress.com/news/2012-09-scientists-genomic-blueprint-heart.html Medical research Thu, 13 Sep 2012 12:46:15 EST news266759167 New research from an international team of HIV/AIDS experts has reaffirmed the effectiveness of Truvada—the first and only medication approved by the FDA for HIV prevention. Led by Gladstone Investigator Robert Grant, MD, MPH and Peter Anderson, PharmD, at the University of Colorado, the research provides the first estimate of the drug concentration levels needed for Truvada to prevent the spread of HIV/AIDS—expanding our understanding of Truvada's potency and opening the door to new dosing strategies. http://medicalxpress.com/news/2012-09-underscores-truvada-potency-transmission-hiv.html HIV & AIDS Wed, 12 Sep 2012 14:00:05 EST news266673587 Scientists at the Gladstone Institutes have gotten us one step closer to understanding and overcoming one of the least-understood mechanisms of HIV infection—by devising a method to precisely track the life cycle of individual cells infected with HIV, the virus that causes AIDS. http://medicalxpress.com/news/2012-09-scientists-technique-decipher-dormant-aids.html HIV & AIDS Tue, 11 Sep 2012 12:54:58 EST news266586891 Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease. http://medicalxpress.com/news/2012-08-epilepsy-drug-levetiracetam-reverses-memory.html Alzheimer's disease & dementia Mon, 06 Aug 2012 15:00:21 EST news263479325 Scientists at the Gladstone Institutes have for the first time transformed skin cells—with a single genetic factor—into cells that develop on their own into an interconnected, functional network of brain cells. The research offers new hope in the fight against many neurological conditions because scientists expect that such a transformation—or reprogramming—of cells may lead to better models for testing drugs for devastating neurodegenerative conditions such as Alzheimer's disease. http://medicalxpress.com/news/2012-06-skin-cells-brain-lab.html Medical research Thu, 07 Jun 2012 12:04:16 EST news258280588 Scientists at the Gladstone Institutes have unraveled a process by which depletion of a specific protein in the brain contributes to the memory problems associated with Alzheimer's disease. These findings provide new insights into the disease's development and may lead to new therapies that could benefit the millions of people worldwide suffering from Alzheimer's and other devastating neurological disorders. http://medicalxpress.com/news/2012-04-scientists-mechanism-contribute-problems-alzheimer.html Alzheimer's disease & dementia Thu, 26 Apr 2012 12:35:50 EST news254662523 Scientists at the Gladstone Institutes today are announcing a research breakthrough in mice that one day may help doctors restore hearts damaged by heart attacks—by converting scar-forming cardiac cells into beating heart muscle. http://medicalxpress.com/news/2012-04-breakthrough-mouse-hearts-regenerated-scar.html Cardiology Wed, 18 Apr 2012 13:00:18 EST news253971807 Scientists at the Gladstone Institutes have enhanced our understanding of how a protein linked to Alzheimer's disease keeps young brains healthy, but can damage them later in life—suggesting new research avenues for treating this devastating disease. http://medicalxpress.com/news/2012-04-scientists-apoe-protein-alzheimer-disease.html Alzheimer's disease & dementia Tue, 03 Apr 2012 17:00:15 EST news252688243