http://medicalxpress.com/ en-us Medical Xpress provides the latest news from H. Lee Moffitt Cancer Center & Research Institute Researchers from Moffitt Cancer Center and the University of South Florida have evaluated how Florida health care and social service agencies distribute "Libres para Siempre", a Spanish smoking relapse prevention booklet series. http://medicalxpress.com/news/2013-05-spanish-relapse-booklets.html Addiction Fri, 17 May 2013 04:27:57 EST news287983647 Researchers at Moffitt Cancer Center say identifying and selecting participants for phase II cancer clinical trials from a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and may speed test drugs through the drug development pipeline. http://medicalxpress.com/news/2013-05-cancer-biorepository-clinical-trials-drug.html Cancer Wed, 08 May 2013 04:28:56 EST news287206049 Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA. http://medicalxpress.com/news/2013-04-deficiency-p53-anti-tumor-protein-dna.html Cancer Tue, 23 Apr 2013 04:46:31 EST news285911182 Researchers at Moffitt Cancer Center and colleagues analyzed national data to investigate the differences in cancer prevention beliefs by race and ethnicity. They found that minorities, including blacks, Asians and Hispanics, have differing beliefs about cancer prevention and feel they are less likely to get cancer than did whites. The researchers concluded that more culturally relevant information about cancer prevention and risk needs to reach minority populations. http://medicalxpress.com/news/2013-04-minorities-cancer-whites.html Cancer Wed, 17 Apr 2013 04:29:08 EST news285391637 Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report that the drug combination of MK-1775 and gemcitabine resulted in a 70 percent decrease in the tumor volume when compared to receiving one drug or the other. http://medicalxpress.com/news/2013-04-two-drug-combo-effective-sarcomas.html Cancer Tue, 09 Apr 2013 14:54:47 EST news284738079 Researchers at Moffitt Cancer Center predict that advancements in breast cancer screening will need a personalized touch because mammography is not a "one strategy fits all" technology. http://medicalxpress.com/news/2013-04-discuss-frontiers-breast-cancer-screening.html Cancer Fri, 05 Apr 2013 04:33:11 EST news284355184 Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity. http://medicalxpress.com/news/2013-04-specific-microrna-tumor-growth-cancer.html Cancer Wed, 03 Apr 2013 15:09:37 EST news284220569 Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health care providers to determine the factors associated with disparities in Human Papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination strategies and the type of practice play a role in whether or not girls were vaccinated. http://medicalxpress.com/news/2013-03-hpv-vaccination-disparities-girls-low-income.html Cancer Wed, 27 Mar 2013 05:11:48 EST news283579901 Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer. This development could impact the treatment of several tumor types, including breast, lung, prostate and others that depend on STAT3 for survival. http://medicalxpress.com/news/2013-03-small-molecule-disrupt-cancer-causing-protein.html Cancer Tue, 26 Mar 2013 05:04:10 EST news283493040 Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in the Jan. 16 issue of The Breast Journal. http://medicalxpress.com/news/2013-03-genetic-strategies-young-black-female.html Cancer Thu, 21 Mar 2013 11:47:54 EST news283085136 Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed treatment with azanucleosides. The therapy may not be effective for all patients, but those with trisomy 8 chromosomal disorder have higher rates of stable disease and respond better to treatment with dasatinib, the study shows. http://medicalxpress.com/news/2013-03-dasatinib-patients-high-risk-mds.html Cancer Thu, 21 Mar 2013 05:19:37 EST news283061956 Researchers at Moffitt Cancer Center and colleagues have found that healthy adolescent females have predetermined expectations for becoming parents in the future, but have concerns about fertility and childbearing should they develop a life-threatening illness, such as cancer. http://medicalxpress.com/news/2013-03-cancer-doesnt-young-girls-desire.html Cancer Fri, 01 Mar 2013 04:51:22 EST news281335873 Researchers at Moffitt Cancer Center studied patients with metastatic gastric cancer and found that those who have both surgery and radiation have better survival than those who receive one or no form of treatment. http://medicalxpress.com/news/2013-02-surgery-survival-metastatic-gastric-cancer.html Cancer Wed, 27 Feb 2013 12:25:32 EST news281190325 Researchers at the Moffitt Cancer Center have found a potential mechanism by which immune suppressive myeloid-derived suppressor cells can prevent immune response from developing in cancer. This mechanism includes silencing the tumor suppressor gene retinoblastoma 1 or Rb1. Their data explains a new regulatory mechanism by which myeloid-derived suppressor cells are expanded in cancer. http://medicalxpress.com/news/2013-02-silencing-retinoblastoma-gene-differentiation-myeloid.html Immunology Tue, 19 Feb 2013 10:30:02 EST news280491528 Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response. http://medicalxpress.com/news/2013-02-moffitt-potential-therapeutic-non-small-cell.html Cancer Fri, 15 Feb 2013 03:17:20 EST news280120593