http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Joslin Diabetes Center Joslin scientists report significant findings about the location, genetic expression and function of human brown adipose tissue (BAT) and the generation of new BAT cells. These findings, which appear in the April 2013 issue of Nature Medicine, may contribute to further study of BAT's role in human metabolism and developing treatments that use BAT to promote weight loss. http://medicalxpress.com/news/2013-04-scientists-advance-human-brown-adipose.html Medical research Mon, 22 Apr 2013 17:35:47 EST news285870940 In a study of patients with type 1 diabetes, Joslin researchers found that dietary fat can affect glucose levels and insulin requirements. These findings, which appeared in the April edition of Diabetes Care, have major implications for the management of type 1 diabetes. http://medicalxpress.com/news/2013-03-dietary-fat-affect-glucose-insulin.html Diabetes Wed, 27 Mar 2013 14:47:34 EST news283614447 Joslin scientists have discovered a mechanism that regulates the production of brown fat, a type of fat which plays an important role in heat production and energy metabolism. The findings, which appear in the upcoming issue of Nature, may lead to new therapies that increase BAT formation to treat obesity. http://medicalxpress.com/news/2013-03-team-mechanism-production-energy-burning-brown.html Medical research Wed, 13 Mar 2013 14:00:04 EST news282396182 Joslin scientists report the first generation of human induced pluripotent stem cells from patients with an uncommon form of diabetes, maturity onset diabetes of the young (MODY). These cells offer a powerful resource for studying the role of genetic factors in the development of MODY and testing potential treatments. The findings appear in the Journal of Biological Chemistry. http://medicalxpress.com/news/2013-01-scientists-human-ipsc-patients-maturity.html Medical research Thu, 31 Jan 2013 12:55:40 EST news278859298 As part of their ongoing research on the physiologic factors that contribute to the development of obesity, Joslin Diabetes Center scientists have identified a cell cycle transcriptional co-regulator – TRIP-Br2 – that plays a major role in energy metabolism and fat storage. This finding has the potential to lead to new treatments for obesity. The study is being published today ahead of print by Nature Medicine. http://medicalxpress.com/news/2013-01-important-factor-fat-storage-energy.html Medical research Sun, 06 Jan 2013 13:00:01 EST news276684146 Joslin Diabetes Center scientists have demonstrated that brown adipose tissue (BAT) has beneficial effects on glucose tolerance, body weight and metabolism. The findings, which may lead to new treatments for diabetes, appear in the upcoming issue of the Journal of Clinical Investigation. http://medicalxpress.com/news/2012-12-brown-adipose-tissue-beneficial-metabolism.html Medical research Mon, 10 Dec 2012 12:00:01 EST news274359138 As part of their ongoing research on the role of genes in the development of type 1 diabetes, Joslin Diabetes Center scientists, in collaboration with scientists at the University of Würzburg, have demonstrated how a genetic variant associated with type 1 diabetes and other autoimmune diseases influences susceptibility to autoimmunity. The findings appear in the upcoming issue of Diabetes. http://medicalxpress.com/news/2012-11-genetic-factor-diabetes.html Diabetes Wed, 28 Nov 2012 13:23:34 EST news273331371 As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor—microRNA processing in fat tissue—which plays a major role in aging and stress resistance. This finding may lead to the development of treatments that increase stress resistance and longevity and improve metabolism. The findings appear in the September 5 online edition of Cell Metabolism. http://medicalxpress.com/news/2012-09-scientists-molecular-fat-cells-stress.html Medical research Wed, 26 Sep 2012 15:18:45 EST news267891514 Scientists at Joslin Diabetes Center have identified biological mechanisms by which glucagon-like peptide-1 (GLP-1), a gut hormone, protects against kidney disease, and also mechanisms that inhibit its actions in diabetes. The findings, which are reported today online by Diabetes, may lead to the development of new therapeutic agents that harness the actions of GLP-1 to prevent the harmful effects of hyperglycemia on renal endothelial cells. http://medicalxpress.com/news/2012-07-joslin-gain-diabetes-kidney-disease.html Diseases, Conditions, Syndromes Mon, 23 Jul 2012 10:27:42 EST news262258055 After people with type 1 diabetes have a heart attack, their long-term chance of suffering even more heart damage skyrockets. But the reason has long puzzled scientists. Now researchers at Joslin Diabetes Center have identified the misstep that sparks this runaway chronic damage and a promising way to block it. http://medicalxpress.com/news/2012-06-cardiac-heart-diabetes.html Cardiology Wed, 13 Jun 2012 14:00:01 EST news258806734 Researchers at Joslin Diabetes Center have shown that while a type of "good" fat found in the body can be activated by cold temperatures, it is not able to be activated by the drug ephedrine. http://medicalxpress.com/news/2012-06-good-fat-cold-ephedrine.html Medical research Mon, 04 Jun 2012 15:00:18 EST news258036263 As the diabetes epidemic spreads worldwide, there is growing concern for Asian American populations, who are nearly twice as likely to develop diabetes, particularly type 2 diabetes. Compounding the problem, many of the standard ways to detect diabetes fail in people of Asian descent. http://medicalxpress.com/news/2012-05-unique-physiology-key-diabetes-asian.html Diabetes Tue, 08 May 2012 14:54:10 EST news255707588 Scientists at Joslin Diabetes Center have identified a key mechanism of action for the TOR (target of rapamycin) protein kinase, a critical regulator of cell growth which plays a major role in illness and aging. This finding not only illuminates the physiology of aging but could lead to new treatments to increase lifespan and control age-related conditions, such as cancer, type 2 diabetes, and neurodegeneration. http://medicalxpress.com/news/2012-05-scientists-important-mechanism-affects-aging.html Medical research Tue, 01 May 2012 14:20:01 EST news255100184