http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Temple University HIV, the virus that causes AIDS, is notorious for hiding within certain types of cells, where it reproduces at a slowed rate and eventually gives rise to chronic inflammation, despite drug therapy. But researchers at Temple University School of Medicine's Department of Pathology and Laboratory Medicine and Center for Substance Abuse Research (CSAR) recently discovered that synthetic anti-inflammatory substances distantly related to the active ingredient of marijuana may be able to take the punch out of HIV while inside one of its major hideouts – immune cells known as macrophages. http://medicalxpress.com/news/2013-05-scientists-weaken-hiv-infection-immune.html HIV & AIDS Wed, 01 May 2013 15:25:25 EST news286640718 A major factor in the advance of heart disease is the death of heart tissue, a process that a team of scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine think could be prevented with new medicines. Now, the researchers are one step closer to achieving that goal, thanks to their discovery of a key molecule in an unexpected place in heart cells – mitochondria, tiny energy factories that house the controls capable of setting off cells' self-destruct sequence. http://medicalxpress.com/news/2013-04-clues-heart-disease-unexpected.html Cardiology Fri, 12 Apr 2013 11:42:31 EST news284985742 Scientists at the Center for Translational Medicine at the Temple University School of Medicine are inching closer to solving a long-standing mystery in sepsis, a complex and often life-threatening condition that affects more than 400,000 people in the U.S. every year. By blocking the activity of a protein, STIM1, in cells that line the insides of blood vessels in mice, they have halted a cascade of cellular events that culminates in the out-of-control inflammation that marks sepsis, and protected lungs from severe damage. http://medicalxpress.com/news/2013-01-strategies-sepsis.html Medical research Fri, 25 Jan 2013 12:00:01 EST news278335012 Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) – the most common cause of cervical cancer – to a common form of childhood epilepsy. They have shown for the first time that HPV16 may be present in the human brain, and found that when they added a viral protein to the brains of fetal mice, the mice all demonstrated the same developmental problems in the cerebral cortex associated with this type of epilepsy, called focal cortical dysplasia type IIB (FCDIIB). The findings suggest that the virus could play a role in the development of epilepsy. http://medicalxpress.com/news/2013-01-scientists-cancer-causing-virus-brain-potential.html Neuroscience Thu, 24 Jan 2013 11:31:23 EST news278249475 Today, mothers of newborns find themselves confronting a common dilemma: Should they let their babies "cry it out" when they wake up at night? Or should they rush to comfort their crying little one? http://medicalxpress.com/news/2013-01-babes-notion-infants.html Psychology & Psychiatry Wed, 02 Jan 2013 15:25:00 EST news276362688 Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair. http://medicalxpress.com/news/2012-12-temple-scientists-dna-eradicate-leukemia.html Cancer Sun, 09 Dec 2012 15:24:55 EST news274289081 Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments. http://medicalxpress.com/news/2012-12-pre-clinical-angiocidin-effective-leukemia.html Cancer Sun, 09 Dec 2012 03:30:01 EST news274244028 Decreased kidney function is associated with decreased cognitive functioning in areas such as global cognitive ability, abstract reasoning and verbal memory, according to a study led by Temple University. This is the first study describing change in multiple domains of cognitive functioning in order to determine which specific abilities are most affected in individuals with impaired renal function. http://medicalxpress.com/news/2012-11-decreased-kidney-function-cognitive-functioning.html Diseases, Conditions, Syndromes Mon, 19 Nov 2012 00:20:01 EST news272473929 With grilled chicken, salads and oatmeal now on fast food menus, you might think fast food has become healthier. And indeed, there has been greater attention in the media and legislatively, paid to the healthfulness of fast food. But a close look at the industry has found that calorie counts have changed little, while the number of food items has doubled. http://medicalxpress.com/news/2012-11-fast-food-menus-lot-calories.html Health Tue, 13 Nov 2012 13:57:38 EST news272037451 When a person has a heart attack, portions of the heart muscle die in the next several days or even weeks if deprived of oxygen for long enough. The recovering heart slowly remodels itself, even fostering the growth of new blood vessels, in an attempt to regain some of its former function. But all too often, the remodeling is actually harmful, and the damaged heart is on an inevitable downward slide to heart failure. http://medicalxpress.com/news/2012-11-protein-heart-recover-scientists.html Cardiology Tue, 06 Nov 2012 11:35:19 EST news271424106 Researchers at Temple University's Center for Translational Medicine and the University of Pennsylvania have identified a protein that serves as a gatekeeper for controlling the rush of calcium into the cell's power source, the mitochondria. Without this calcium spigot under control, calcium levels can run amok, contributing to cardiovascular disease, diabetes and neurodegeneration. The findings, reported online October 25, 2012, in the journal Cell, add important new insights into the inner workings of the mitochondria and may eventually help scientists better understand and target certain cellular processes gone awry, leading to new therapies for disease. http://medicalxpress.com/news/2012-10-gatekeeper-protein-cell-power-source.html Medical research Thu, 25 Oct 2012 13:50:01 EST news270389746 Could a clinic-based intervention that assists in dealing with childhood obesity be scaled down into an easily-taught, community-based program? Yes, according to a new feasibility study conducted by researchers at Temple University's Center for Obesity Research and Education and published in the journal, Pediatrics. http://medicalxpress.com/news/2012-09-clinic-based-childhood-obesity.html Pediatrics Mon, 17 Sep 2012 04:38:44 EST news267075516 Spatial skills--those involved with reading maps and assembling furniture--can be improved if you work at it, that's according to a new look at the studies on this topic by researchers at Northwestern University and Temple. http://medicalxpress.com/news/2012-07-spatial-skills.html Psychology & Psychiatry Wed, 25 Jul 2012 11:21:07 EST news262434058 In a tight economy, with fewer jobs, many people end up working harder and sacrificing more to stay employed. A new study finds that one of those sacrifices is sometimes their own and their family's nutrition. http://medicalxpress.com/news/2012-06-parents-work-life-stress-hinders-healthy.html Health Fri, 22 Jun 2012 14:01:04 EST news259592263 After years of reducing their contact with pharmaceutical sales representatives, physicians now risk an unintended consequence: Doctors who rarely meet with pharmaceutical sales representatives — or who do not meet with them — are much slower to drop medicines with the Food and Drug Administration's "black box" warnings and to adopt first-in-class therapies. http://medicalxpress.com/news/2012-05-docs-slower-black-drugs-therapies.html Health Wed, 23 May 2012 17:25:08 EST news257012638