http://medicalxpress.com/ en-us Medical Xpress provides the latest news from Trinity College Dublin Scientists at Trinity College Dublin have made novel discoveries concerning the current vaccine against whooping cough that may lead to the development of an improved future vaccine. The findings could help reduce the incidence of the disease which is increasing in developed countries. The research led by Professor of Experimental Immunology, Kingston Mills has just been published in the leading international journal PloS Pathogens. http://medicalxpress.com/news/2013-05-discovery-whooping-vaccine.html Diseases, Conditions, Syndromes Mon, 13 May 2013 08:10:01 EST news287649713 (Medical Xpress)—Patient behaviour is one of the biggest causes of delay in getting to hospital when suffering a heart attack according to the findings of a new HRB-funded study at Trinity College Dublin. The delay is a result of people not associating their symptoms with a heart attack, contacting their GP first, taking medication and being slow to use emergency services. http://medicalxpress.com/news/2013-05-irish-people-hospital-heart-symptoms.html Cardiology Wed, 01 May 2013 06:50:01 EST news286608893 (Medical Xpress)—Trinity College Dublin scientists have made a significant breakthrough in understanding the immune system that could lead to new treatments for diseases such as sepsis and Type 2 diabetes. A team led by Professor of Biochemistry, Luke O'Neill of the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute has revealed that during an infection, immune cells switch their "engine" from the more sedate "battery" power, to using the equivalent of petrol to supercharge the engine needed to fight the infection. The work has just been published in the international leading science journal Nature. http://medicalxpress.com/news/2013-04-reveal-immune-turbo-charged-hybrid-car.html Immunology Thu, 04 Apr 2013 06:17:21 EST news284275032 A collaboration between researchers at the School of Biochemistry and Immunology and the Department of Microbiology at Trinity College Dublin has identified a mechanism by which the bacterium Staphylococcus aureus (S. aureus) colonises our nasal passages. The study, recently published in the prestigious journal PLOS Pathogens, shows for the first time that a protein located on the bacterial surface called clumping factor B (ClfB) recognises a protein called loricrin that is a major component of the envelope of cells in the nose and skin. http://medicalxpress.com/news/2013-01-bacterium-role-mrsa-colonises-human.html Diseases, Conditions, Syndromes Mon, 28 Jan 2013 08:09:35 EST news278582968 Investment in end-of-life care has made Ireland a world leader in advancing palliative and hospice care but regional inequities persist, according to an evaluation report just published by the Dean of Health Sciences at Trinity College Dublin, Professor Mary McCarron and colleagues at the School of Nursing and Midwifery. The Trinity report examined The Atlantic Philanthropies funded 'End of Life programme' – which aimed to improve the care and quality of life for patients dying from an incurable illness and to ensure they and their families received excellent end-of-life care and services.  http://medicalxpress.com/news/2013-01-palliative-hospice-ireland.html Health Wed, 23 Jan 2013 06:21:48 EST news278144495 (Medical Xpress)—New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the development of tumours. http://medicalxpress.com/news/2012-12-cellular-metabolism-arms-cells-viruses.html Medical research Mon, 24 Dec 2012 13:28:11 EST news275578081 (Medical Xpress)—Neuroscience researchers at Trinity College Dublin have opened a new avenue for research on how the brain enables us to make decisions about our environment. By observing the gradual formation of a decision in brain activity before the particular decision was actually reported, the findings also have the potential to contribute to improved understanding and diagnosis of numerous brain disorders that are associated with impaired perceptual decision making. The discovery was recently published in Nature Neuroscience. http://medicalxpress.com/news/2012-12-brain-decisions.html Neuroscience Tue, 04 Dec 2012 06:21:56 EST news273824505 A report into Bullying of People with Intellectual Disabilities and an Easy to Read Bullying Information Guide, compiled by the National Institute for Intellectual Disability (NIID), Trinity College Dublin in association with the National Anti-Bullying Advocacy Group (NAAG), was launched o recent by the Director of the National Disability Authority, Siobhan Barron.  http://medicalxpress.com/news/2012-11-bullying-people-intellectual-disabilities.html Psychology & Psychiatry Thu, 08 Nov 2012 06:14:45 EST news271577644 Research just carried out in the Immunology Research Centre, led by Dr James Harris, based in the School of Biochemistry and Immunology, Trinity College Dublin, shows that the process of autophagy  regulates the production of inflammatory molecules and may therefore represent an effective target for the development of new anti-inflammatory therapeutics. The findings have been recently published online in the Journal of Immunology. http://medicalxpress.com/news/2012-10-important-role-autophagy-self-eating-cells.html Medical research Wed, 24 Oct 2012 10:00:01 EST news270286150 (Medical Xpress)—Researchers at Trinity College Dublin in collaboration with colleagues in the Department of Neurology at St Vincent's University Hospital and University College Dublin have recently reported new insights into cognitive changes in multiple sclerosis, using newly developed signal processing methods. The findings have been recently published in the international journal PlosOne. http://medicalxpress.com/news/2012-10-insight-cognitive-multiple-sclerosis.html Neuroscience Wed, 10 Oct 2012 10:00:01 EST news269081075 (Medical Xpress)—New research has found that a type of anti-tumour immune cell protects against obesity and the metabolic syndrome that leads to diabetes. Results showing that immune cells known to be protective against malignancy called invariant natural killer T-cells (iNKT), that are lost when humans become obese, but can be restored through weight loss, have been published online this week in the journal Immunity. Marie Curie Fellow, Lydia Lynch at Trinity College Dublin, Ireland made the discovery and as first author in collaboration with colleagues at Harvard-affiliated Beth Israel Deaconess Medical Centre, and St Vincent's University Hospital have shown that therapies that activate iNKT cells could help manage obesity, diabetes, and metabolic disease. http://medicalxpress.com/news/2012-10-scientists-immune-cells-obesity.html Immunology Mon, 01 Oct 2012 18:59:42 EST news268336763 (Medical Xpress) -- A new study by TCD researchers investigates drug-resistant ovarian cancer cells. The findings which have been recently published in the international publication, PLoS One will increase understanding of molecular markers in drug-resistant ovarian cancer with a view to improving clinical treatment. http://medicalxpress.com/news/2012-08-drug-resistant-ovarian-cancer-clinical.html Cancer Thu, 09 Aug 2012 08:47:52 EST news263720848 (Medical Xpress) -- New ways that viruses manipulate the human immune response have been revealed in a research paper just published in Nature involving TCD scientists. Dr Orla Mulhern and Professor Andrew Bowie, School of Biochemistry and Immunology based in the Trinity Biomedical Sciences Institute were part of the multi-disciplinary, multi-centre study comprising immunologists, virologists, biochemists and bioinformaticians from across Europe. http://medicalxpress.com/news/2012-08-ways-viruses-affect-human-immune.html Immunology Fri, 03 Aug 2012 07:52:15 EST news263199129 (Medical Xpress) -- Medical Scientists at Trinity College Dublin in a pan-European collaborative study have discovered genes that contribute to the condition vasculitis, causing the inflammation of blood vessels. The findings have been recently published in the leading international publication The New England Journal of Medicine. http://medicalxpress.com/news/2012-08-vasculitis-genes-inflammation-blood-vessels.html Inflammatory disorders Thu, 02 Aug 2012 10:03:19 EST news263120562 (Medical Xpress) -- A team of researchers at Trinity College Dublin’s School of Medicine has gained new insights into a protein in the human immune system that plays a key role in the protective response to infection and inflammation. The research findings have just been published in the internationally renowned peer-reviewed Journal of Biological Chemistry. http://medicalxpress.com/news/2012-07-breakthrough-human-immune-response-potential.html Immunology Fri, 06 Jul 2012 08:31:30 EST news260782255