http://medicalxpress.com/ en-us Medical Xpress provides the latest news from University of Helsinki Finnish researchers have shown that genetic marker information can improve risk evaluation of coronary heart disease. The study comprised over 24,000 Finnish subjects and was led by Professor Samuli Ripatti. The results revealed that a panel of 28 genetic markers improved detection of individuals with high risk for coronary heart disease (CHD) (10-year risk ≥20%) over traditional risk factors. http://medicalxpress.com/news/2013-05-genetic-screening-reveal-hidden-high.html Cardiology Mon, 20 May 2013 07:12:24 EST news288252731 (Medical Xpress)—Cornell researchers have uncovered the basic cell biology that helps explain heart defects found in diseases known as laminopathies, a group of some 15 genetic disorders that include forms of muscular dystrophy and between 5 percent and 10 percent of all cases of inherited heart disease. http://medicalxpress.com/news/2013-05-laminopathies-key-components-disease-mechanism.html Medical research Tue, 07 May 2013 07:26:31 EST news287130376 Many of the genes regulating the inflammation and immune response of the body are also associated with low HDL-cholesterol levels in the circulation, tells the recent study conducted at the University of Helsinki, Finland. The research also discovered that the quality of HDL particle can vary considerably. http://medicalxpress.com/news/2013-04-hdl-cholesterolnot-quantity-quality.html Cardiology Tue, 30 Apr 2013 08:54:56 EST news286530889 Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal for cancer cells because activation of a mitochondria-addressed cell death pathway. http://medicalxpress.com/news/2013-04-cancer-cell-metabolism.html Cancer Mon, 15 Apr 2013 15:00:04 EST news285240873 We should reconsider how we use antidepressants more effectively. The latest studies have shown that antidepressants restore the capacity of certain areas of the brain to repair abnormal neural pathways. According to neuroscientist Eero Castrén, the recipient of EUR 2.5 million of ERC funding, recovery requires redirection of these pathways through practice, rehabilitation or therapy. http://medicalxpress.com/news/2013-02-antidepressants.html Psychology & Psychiatry Fri, 22 Feb 2013 09:38:20 EST news280748191 Pompe disease, a severe glycogen storage disease appearing in Lapphunds is caused by a genetic defect in acid α-glucosidase gene. The same genetic mutation also causes the equivalent disease in humans. Based on this finding, canine Pompe disease can now be diagnosed with a genetic test. http://medicalxpress.com/news/2013-02-genetic-defect-pompe-disease-humans.html Genetics Fri, 15 Feb 2013 14:40:03 EST news280158933 (Medical Xpress)—According to an updated Cochrane review on vitamin C and the common cold, vitamin C seems to be particularly beneficial for people under heavy physical stress. http://medicalxpress.com/news/2013-02-vitamin-beneficial-common-cold.html Health Wed, 13 Feb 2013 11:10:01 EST news279973273 (Medical Xpress)—Even with a constant task, human performance fluctuates in time-scales from seconds to minutes in a fractal manner. In a recent study a Finnish research group found that the individual variability in the brain dynamics as indexed by the neuronal scaling laws predicted the individual behavioral variability and the conscious detection of very weak sensory stimuli. These data indicate that individual neuronal dynamics underlie the individual variability in human cognition and performance. Results may also have a strong impact in understanding the neuronal mechanism of neuropsychiatric diseases in which behavioral dynamics are abnormal. http://medicalxpress.com/news/2013-02-memories-brain-streaks-individual-behaviour.html Neuroscience Tue, 12 Feb 2013 16:46:37 EST news279909984 Research has shown that mutations in the psen1 gene are common in the familial forms of Alzheimer's disease, and the Presenilin-1 protein that the gene encodes is known to be involved in the cleavage of the amyloid precursor protein. In Alzheimer's disease the amyloid precursor protein is not cleaved the normal way, and the protein accumulates in the brain damaging neuronal tracts and neurons. It is still unknown if the psen1 gene is involved in the etiology of Alzheimer's disease via another mechanism. http://medicalxpress.com/news/2013-02-zebrafish-reveals-central-brain-histamine.html Neuroscience Tue, 05 Feb 2013 09:33:24 EST news279279143 A Finnish study shows that patients who have experienced subarachnoid haemorrhage (SAH) have a highly increased risk of death due to a stroke or cerebral haemorrhage, and have double the mortality rate of the general population. The researchers state that considerably more attention should be paid to risk factors in the life of SAH survivors. http://medicalxpress.com/news/2013-01-high-blood-pressure-cholesterol-fatal.html Neuroscience Mon, 14 Jan 2013 07:13:38 EST news277370010 "Understanding peoples' attitudes about whether states of being should be considered diseases can inform social discourse regarding a number of contentious social and health public policy issues," says Kari Tikkinen, MD, PhD, corresponding author of the FIND Survey.   http://medicalxpress.com/news/2012-12-grief-disease-cancer-erectile-dysfunction.html Health Mon, 03 Dec 2012 07:36:43 EST news273742595 New research from the University of Helsinki, Finland, suggests that a mother's high blood pressure during pregnancy may have an effect on her child's thinking skills all the way into old age. The study is published in the October 3, 2012, online issue of Neurology. http://medicalxpress.com/news/2012-10-mom-high-blood-pressure-pregnancy.html Neuroscience Wed, 03 Oct 2012 16:00:03 EST news268488898 The genetics research group led by Professor Hannes Lohi, based at the University of Helsinki and the Folkhälsan Research Center, has, in collaboration with Adjunct Professor Kirsi Sainio's research group, discovered the cause of a life-threatening skeletal disorder affecting Brazilian Terriers. The disease is caused by a mutation in the GUSB gene. Malfunction of the GUSB gene has previously been linked to a severe skeletal disorder in humans, called type VII mucopolysaccharidosis (MPS VII). http://medicalxpress.com/news/2012-08-genetic-severe-skeletal-disease-brazilian.html Genetics Mon, 06 Aug 2012 10:38:56 EST news263468295 Researchers at the University of Helsinki and the Folkhälsan Research Center, Finland, have identified the genetic cause of early-onset progressive cerebellar degeneration the Finnish Hound dog breed. The study, led by Professor Hannes Lohi, revealed a new disease mechanism in cerebellar degeneration. A mutation was identified in the SEL1L gene, which has no previous link to inherited cerebellar ataxias. http://medicalxpress.com/news/2012-06-cerebellar-ataxia-gene-dogs.html Genetics Mon, 18 Jun 2012 10:00:11 EST news259232393 An international research group has identified four new gene loci predisposing people to the most common subtype of migraine, migraine without aura. About two-thirds of migraine sufferers belong to this group. The study will be published in Nature Genetics on June 10, 2012. http://medicalxpress.com/news/2012-06-gene-loci-predispose-people-common.html Genetics Sun, 10 Jun 2012 13:00:12 EST news258548619