http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. (HealthDay)—There has been a significant increase in adverse drug reactions (ADRs) associated with use of trimethoprim-sulfamethoxazole (TMP-SMX) for treatment of skin and soft tissue infection (SSTI) in children, according to research published online Dec. 3 in Pediatrics. http://medicalxpress.com/news/2012-12-adverse-tmp-smx-reactions-children.html Pediatrics Mon, 03 Dec 2012 17:30:01 EST news273776362 In an open letter to company director, Professor Sir John Bell, she says: "Billions of pounds of public money have been spent on [Tamiflu] and yet the evidence on its effectiveness and safety remains hidden from appropriate and necessary independent scrutiny." http://medicalxpress.com/news/2012-10-bmj-editor-urges-roche-fulfil.html Medications Tue, 30 Oct 2012 14:10:02 EST news270824257 Many parents are dissatisfied with communication regarding adverse drug reactions experienced by their child, and the implications of such reactions for the child's future use of medicines, according to a new study published Oct. 10 in the open access journal PLOS ONE by Bridget Young from the University of Liverpool, UK and colleagues. http://medicalxpress.com/news/2012-10-parent-clinician-children-drug-reactions.html Health Wed, 10 Oct 2012 17:00:22 EST news269106397 Experiencing nausea, headaches or other side effects from prescriptions or over-the-counter medicines? Researchers say tweeting about it or posting your concerns online could one day help alert drug companies and federal regulators to problems more quickly—potentially saving lives and money. http://medicalxpress.com/news/2012-10-profs-aim-track-drug-reactions.html Medications Wed, 03 Oct 2012 17:50:02 EST news268504405 Adverse drug reactions are a major issue that cause harm, are costly and restrict treatment options for patients and the development of new drugs. A groundbreaking finding by researchers from the La Jolla Institute for Allergy & Immunology could lead to a new way to dramatically improve drug safety by identifying drugs at risk to cause potentially fatal genetic-linked hypersensitivity reactions before their use in man. http://medicalxpress.com/news/2012-05-discovery-screen-drugs-adverse-reactions.html Immunology Tue, 29 May 2012 09:52:34 EST news257503911 (HealthDay) -- Use of diagnostic codes, such as International Classification of Diseases -- Ninth Revision (ICD-9) codes, may result in misclassification of rare, adverse drug reactions (ADRs), including the risk of rhabdomyolysis from high-dose simvastatin, according to a research letter published in the April 18 issue of the Journal of the American Medical Association, a theme issue on comparative effectiveness research. http://medicalxpress.com/news/2012-04-icd-codes-underestimate-statin-linked-rhabdomyolysis.html Medications Wed, 18 Apr 2012 01:20:01 EST news253928794 (HealthDay) -- Children who are allergic to penicillin are not more likely than other kids to develop additional drug allergies, new research suggests. http://medicalxpress.com/news/2012-03-kids-penicillin-allergy-drug-reactions.html Inflammatory disorders Thu, 08 Mar 2012 04:40:02 EST news250403088 Short-term use of the antibiotic cefpodoxime for the treatment of women with uncomplicated cystitis (bladder infection) did not meet criteria for noninferiority for achieving clinical cure compared with ciprofloxacin, a drug in the fluoroquinolone class of antibiotics for which there have been concerns about overuse and a resulting increase in resistance rates, according to a study in the February 8 issue of JAMA. The criteria for noninferiority was if the efficacy of cefpodoxime had been shown to be within a pre-specified margin of 10 percent of the efficacy of ciprofloxacin. http://medicalxpress.com/news/2012-02-antibiotic-option-bladder-infection-women.html Diseases, Conditions, Syndromes Tue, 07 Feb 2012 16:41:24 EST news247855241 In a move aimed at bolstering current systems for assessing and monitoring drug safety, researchers at Children's Hospital Boston have created a new method that combines multiple forms of widely available data to predict adverse drug reactions. Unlike current approaches, which rely on detecting evidence of drug safety issues as they accumulate over time in clinical databases, this new method may be able to identify issues years in advance. http://medicalxpress.com/news/2011-12-approach-adverse-drug-reactions.html Medications Wed, 21 Dec 2011 14:00:04 EST news243694936 New research reveals that patients with epilepsy who were treated for extended periods with older generation antiepileptic drugs (AEDs) may be at increased risk for developing atherosclerosis, a common disorder known as hardening of the arteries. According to the findings now available in Epilepsia, the journal of the International League Against Epilepsy (ILAE), the vascular risk is significantly associated with the duration of AED monotherapy. http://medicalxpress.com/news/2011-11-vascular-linked-long-term-antiepileptic-drug.html Cardiology Tue, 15 Nov 2011 04:10:03 EST news240551375 Hyderabad, India: Many cases of adverse drug reactions (ADRs) seen in hospital and emergency care could be prevented, says a new study to be presented to the annual conference of the International Pharmaceutical federation (FIP) tomorrow (Thursday) . The researchers who carried out the study say that the finding that preventable ADRs are so widespread has important implications for healthcare systems. http://medicalxpress.com/news/2011-09-adverse-drug-reactions-hospital-emergency.html Health Wed, 07 Sep 2011 04:20:20 EST news234588012 Experts have called for increased awareness about the issue of adverse drug reactions after hearing how everyday prescription medicines are destroying the lives of some patients. http://medicalxpress.com/news/2011-07-everyday-medicines-conference.html Medications Thu, 07 Jul 2011 13:24:57 EST news229263872 On average, a drug on the market works effectively for only 50% of the people who take it. Would you want to prevent a potential adverse drug effect or even toxicity through a simple test? It's not science fiction, but a reality. Pharmacogenetics (PGx) is the study of an individual's variation in DNA sequence related to drug response. The goal is to select the right drug at the right dose, and to avoid adverse drug reactions or ineffective treatment. http://medicalxpress.com/news/2011-04-pharmacogenetics-deaths-drug-toxicity.html Medical research Mon, 11 Apr 2011 11:51:19 EST news221741469 Contrary to popular belief among physicians, frailty in elderly patients is not associated with an increased risk of adverse reactions to medications, according to a study led by Michael Steinman, MD, a geriatrician at the San Francisco VA Medical Center. http://medicalxpress.com/news/2011-04-frailty-factor-adverse-drug-reactions.html Medications Thu, 07 Apr 2011 09:48:20 EST news221388479