http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that this so-called "master regulator" gene may be the key to developing a new treatment for tumors resistant to current drugs. http://medicalxpress.com/news/2013-05-cancer-cancerous-blocking-gene-tumors.html Cancer Thu, 02 May 2013 17:02:44 EST news286732952 (HealthDay)—Life expectancy of people with aggressive brain cancer may be easier to determine with a new method under development at the University of Alabama at Birmingham, researchers say. http://medicalxpress.com/news/2013-04-gauging-brain-cancer-survival-easier.html Cancer Wed, 10 Apr 2013 19:00:01 EST news284834780 A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain—providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells. http://medicalxpress.com/news/2013-02-key-enzyme-aggressive-breast-cancer.html Cancer Thu, 28 Feb 2013 13:45:04 EST news281281484 An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutations—mutations that would suggest new targets for neuroblastoma treatment. Instead, say the researchers, they have now refocused on how neuroblastoma tumors evolve in response to medicine and other factors. http://medicalxpress.com/news/2013-01-tumors-evolve-rapidly-childhood-cancer.html Genetics Sun, 20 Jan 2013 13:00:27 EST news277901484 Data published online today in Blood, the Journal of the American Society of Hematology (ASH) describe the work of an ASH international clinical network collaborative focused on modernizing treatment protocols for patients in the developing world with acute promyeloctyic leukemia (APL) that has drastically improved cure rates in patients in Central and South America, achieving comparable outcomes to those observed in patients in the United States and in Europe. http://medicalxpress.com/news/2013-01-ash-international-clinical-collaboration-replicates.html Cancer Mon, 14 Jan 2013 10:56:03 EST news277383345 Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell behavior in a wide range of current biological research. http://medicalxpress.com/news/2012-10-whitehead-scientists-major-flaw-standard.html Genetics Thu, 25 Oct 2012 13:51:19 EST news270391823 (Medical Xpress)—It seems as if a tumor deprived of oxygen would shrink. However, numerous studies have shown that tumor hypoxia, in which portions of the tumor have significantly low oxygen concentrations, is in fact linked with more aggressive tumor behavior and poorer prognosis. It's as if rather than succumbing to gently hypoxic conditions, the lack of oxygen commonly created as a tumor outgrows its blood supply signals a tumor to grow and metastasize in search of new oxygen sources – for example, hypoxic bladder cancers are likely to metastasize to the lungs, which is frequently deadly. http://medicalxpress.com/news/2012-09-lack-oxygen-cancer-cells-growth.html Cancer Thu, 13 Sep 2012 11:36:25 EST news266754978 Researchers at Mayo Clinic have completed the world's first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking the genetic secrets of this poorly understood and highly aggressive cancer of the immune system. http://medicalxpress.com/news/2012-08-mayo-clinic-genome-wide-analysis-peripheral.html Cancer Wed, 01 Aug 2012 10:56:11 EST news263037362 Researchers at The University of Nottingham have identified three sets of genetic markers that could potentially pave the way for new diagnostic tools for a deadly type of brain tumour that mainly targets children. http://medicalxpress.com/news/2012-06-genetic-markers-brain-tumor-treatments.html Cancer Fri, 15 Jun 2012 11:06:09 EST news258977156 We have known for years that when the proteins RalA and RalB are present, cells in dishes copy toward aggressive forms of cancer. However, until this week, no study had explored the effects of RAL proteins in human cancers – an essential step on the path to developing drugs to target these proteins. From metastasis in bladder cancer, to seminal vessel involvement in prostate cancer, to shortened survival in squamous cell carcinoma, a study published this week in the journal Cancer Research shows that proteins RalA and RalB are associated with aggressive cancer characteristics in human tumors. http://medicalxpress.com/news/2012-05-protein-ral-aggressive-characteristics-prostate.html Cancer Thu, 17 May 2012 13:06:47 EST news256478801 Endocrinologists at the University of Birmingham have played a key role in a major international clinical trial which has found that giving a combination of chemotherapy drugs to patients suffering from advanced adrenal cancer can help them to live up to a fifth longer. http://medicalxpress.com/news/2012-05-combination-chemotherapy-benefits-adrenal-cancer.html Cancer Fri, 04 May 2012 04:31:10 EST news255324652 New results presented at 3rd European Lung Cancer Conference in Geneva, Switzerland show important steps being made to improve the diagnosis and treatment of malignant pleural mesothelioma, an aggressive cancer of the outer lining of the lungs caused by asbestos exposure. http://medicalxpress.com/news/2012-04-early-diagnosis-treatment-mesothelioma.html Cancer Wed, 18 Apr 2012 11:16:31 EST news253966584 Working with mouse models, researchers have found a strong connection between autoimmune arthritis and increased aggressiveness in metastatic breast cancer. The connection appears to involve the tendency of autoimmune arthritis to increase production of mast cells, an immune cell type that increases inflammation and that is prevalent in metastatic tumors. By blocking a key receptor, the researchers were able to affect the interaction between the cancer and mast cells and lessen metastasis. http://medicalxpress.com/news/2012-04-mechanism-metastatic-breast-cancer-arthritis.html Immunology Sun, 01 Apr 2012 12:30:35 EST news252502214 In the largest study of its kind, researchers have profiled genetic changes in cancer with drug sensitivity in order to develop a personalised approach to cancer treatments. The study is published in Nature on Thursday 29 March 2012. http://medicalxpress.com/news/2012-03-path-personalized-cancer-treatment.html Cancer Wed, 28 Mar 2012 13:00:03 EST news252151008 Among patients with a high risk of recurrence of a gastrointestinal stromal tumor following surgery for its removal, patients who received imatinib (a drug to treat certain cancers) for 3 years instead of 1 had improved recurrence-free survival and overall survival, according to a study in the March 28 issue of JAMA. http://medicalxpress.com/news/2012-03-longer-treatment-cancer-drug-gi.html Cancer Tue, 27 Mar 2012 16:00:01 EST news252082285 Low bone density medications, such as Fosamax, Boniva and Actonel, may have a protective effect for endometrial cancer, according to a study at Henry Ford Hospital. http://medicalxpress.com/news/2012-03-bone-density-medications-effect-endometrial.html Cancer Wed, 21 Mar 2012 14:36:04 EST news251559316 The UC Cancer Institute is one of three centers internationally approved to test an experimental drug's safety and pharmacokinetics and also assess the clinical benefit against recurrent malignant glioma, an aggressive form of brain cancer. http://medicalxpress.com/news/2012-02-first-in-human-drug-malignant-glioma-experimental.html Cancer Wed, 15 Feb 2012 11:58:39 EST news248529502 A nine-year-old girl is making what doctors described as a remarkable recovery Sunday, days after surgeons transplanted six of her organs in a groundbreaking medical procedure. http://medicalxpress.com/news/2012-02-girl-six-organ-transplant.html Other Sun, 05 Feb 2012 14:51:49 EST news247675832 Just as people's bodies and minds can become addicted to substances such as drugs, caffeine, alcohol, their cancers can become addicted to certain genes that insure their continued growth and dominance. http://medicalxpress.com/news/2011-12-oncogene-cancer-cell-treatment.html Cancer Thu, 08 Dec 2011 14:00:02 EST news242573362 Women with the deadliest and rarest form of breast cancer now have a chance of treatment where once their options were severely limited, thanks to a new discovery by George Mason University researchers. http://medicalxpress.com/news/2011-11-women-deadliest-breast-cancer.html Cancer Mon, 14 Nov 2011 11:25:22 EST news240492310 An Australian man endured seven rounds of chemotherapy and had 80 percent of his stomach removed after being told he had cancer, only to later learn it was a misdiagnosis, reports said Sunday. http://medicalxpress.com/news/2011-11-australian-sues-surgical.html Other Sun, 13 Nov 2011 06:36:32 EST news240388581 Researchers from the University of Michigan Comprehensive Cancer Center have identified a specific molecule that alters how breast cancer cells move. This affects the cells' ability to spread or metastasize to distant parts of the body, the hallmark of deadly, aggressive cancer. http://medicalxpress.com/news/2011-10-cell-movement-clues-aggressive-breast.html Cancer Mon, 03 Oct 2011 11:47:08 EST news236861210 Certain cancer signaling pathways that are activated in aggressive cancer can be detected very early, even in precancerous cells, among young African-American women at high risk for breast cancer. This may allow for earlier detection and prevention of cancer. http://medicalxpress.com/news/2011-09-breast-cancers-earlier-young-high-risk.html Cancer Tue, 20 Sep 2011 12:08:01 EST news235739250 For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads. http://medicalxpress.com/news/2011-08-uncovering-deadly-cancer.html Cancer Fri, 26 Aug 2011 10:38:11 EST news233573873 Scientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies. http://medicalxpress.com/news/2011-06-scientists-overactive-genes-aggressive-breast.html Cancer Wed, 01 Jun 2011 12:14:51 EST news226149269