http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer. http://medicalxpress.com/news/2013-05-immune-surveillance-war-cancer.html Genetics Thu, 09 May 2013 10:53:22 EST news287315589 A new genetic test to gauge the aggressiveness of prostate cancer may help tens of thousands of men each year decide whether they need to treat their cancer right away or can safely monitor it. http://medicalxpress.com/news/2013-05-gene-prostate-cancer-treatment.html Genetics Wed, 08 May 2013 04:44:19 EST news287207046 With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine. http://medicalxpress.com/news/2013-04-genetic-variants-psa-technique-biopsies.html Cancer Wed, 24 Apr 2013 15:47:26 EST news286037239 Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer. http://medicalxpress.com/news/2013-04-pathway-tamoxifen-aggressive-breast-cancer.html Cancer Tue, 23 Apr 2013 12:47:35 EST news285940047 Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy. The guidelines are published in the current issue of the journal Mayo Clinic Proceedings and represent a consensus opinion of hematologists at Mayo Clinic Cancer Center sites in Minnesota, Florida and Arizona. http://medicalxpress.com/news/2013-04-multiple-myeloma-treatment-guidelines-personalize.html Cancer Mon, 01 Apr 2013 12:23:08 EST news284037777 Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in the Jan. 16 issue of The Breast Journal. http://medicalxpress.com/news/2013-03-genetic-strategies-young-black-female.html Cancer Thu, 21 Mar 2013 11:47:54 EST news283085136 An analysis of breast cancer trends in the U.S. finds a small but statistically significant increase in the incidence of advanced breast cancer for women 25 to 39 years of age, without a corresponding increase in older women, according to a study appearing in the February 27 issue of JAMA. http://medicalxpress.com/news/2013-02-small-incidence-advanced-breast-cancer.html Cancer Tue, 26 Feb 2013 16:00:11 EST news281108310 A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer. Published in Science Translational Medicine (embargoed Jan. 23 at 2:00 pm ET), the study lays the early foundation for predicting which breast cancer patients may develop more aggressive disease and for designing more effective treatments. http://medicalxpress.com/news/2013-01-prognostic-marker-aggressive-breast-cancer.html Cancer Wed, 23 Jan 2013 14:00:01 EST news278165172 Measurements taken over time of prostate specific antigen, the most commonly used screening test for prostate cancer in men, improve the accuracy of aggressive prostate cancer detection when compared to a single measurement of PSA, according to a Kaiser Permanente study published today in the British Journal of Urology International. http://medicalxpress.com/news/2013-01-psa-aggressive-prostate-cancer.html Cancer Tue, 15 Jan 2013 11:00:02 EST news277452788 By harnessing the very qualities that make sickle cell disease a lethal blood disorder, a research team led by Duke Medicine and Jenomic, a private cancer research company in Carmel, Calif., has developed a way to deploy the misshapen red blood cells to fight cancer tumors. http://medicalxpress.com/news/2013-01-sickle-cells-potential-aggressive-cancer.html Cancer Wed, 09 Jan 2013 17:00:06 EST news276961342 Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation chemoprevention therapy. http://medicalxpress.com/news/2012-12-prostate-cancer-androgen-deprivation-effects.html Cancer Thu, 20 Dec 2012 10:39:48 EST news275222382 A two-prong approach combining ibrutinib and rituximab (Rituxin®) to treat aggressive chronic lymphocytic leukemia (CLL) produced profound responses with minor side effects in a Phase 2 clinical trial at the University of Texas MD Anderson Cancer Center. http://medicalxpress.com/news/2012-12-drug-combination-aggressive-chronic-lymphocytic.html Cancer Mon, 10 Dec 2012 17:02:11 EST news274381317 (Medical Xpress)—In the first of its kind, a translational study undertaken at the Malaghan Institute of Medical Research has revealed that boosting the activity of a rare type of immune cell could be an effective way to vaccinate patients with chronic lymphocytic leukaemia (CLL) against their own cancer. http://medicalxpress.com/news/2012-11-boosting-immune-responses-leukaemia.html Cancer Wed, 21 Nov 2012 08:48:22 EST news272710049 (HealthDay)—Prostate cancer patients who, before their diagnosis, routinely consumed hefty helpings of the flavonoid compounds found in plant-based foods and drinks may be at lower risk for the most aggressive form of the disease, new research suggests. http://medicalxpress.com/news/2012-10-antioxidants-tea-fruit-veggies-prostate.html Cancer Wed, 17 Oct 2012 19:40:02 EST news269714322 (Medical Xpress)—Monash Institute of Medical Research scientists may have discovered a way of blocking stomach tumours from growing and spreading, according to a paper published in the highly-prestigious journal Cancer Cell. http://medicalxpress.com/news/2012-10-scientists-block-stomach-tumor-growth.html Cancer Tue, 16 Oct 2012 08:56:40 EST news269596573 Scientists have discovered two separate genetic 'signatures' for prostate cancer that appear to be able to predict the severity of the disease, leading to hopes that in future, accuracy of prognosis and treatment of the disease could be greatly improved. Two Articles published in The Lancet Oncology reveal distinctive patterns of RNA—the genetic material that helps turn DNA into proteins—which appear to be able to predict whether patients have an aggressive prostate cancer, or whether they have a milder form of the disease. http://medicalxpress.com/news/2012-10-scientists-genetic-signatures-aggressive-prostate.html Cancer Mon, 08 Oct 2012 18:30:01 EST news268913570 A common enzyme that is easily detected in blood may predict how well patients with advanced kidney cancer will respond to a specific treatment, according to doctors at Duke Cancer Institute. http://medicalxpress.com/news/2012-08-blood-treatment-kidney-cancer.html Cancer Mon, 13 Aug 2012 16:00:08 EST news264091838 Using a new assay method to study tumor cells, researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center have found evidence of clonal evolution in chronic lymphocytic leukemia (CLL). The assay method distinguishes features of leukemia cells that indicate whether the disease will be aggressive or slow-moving, a key factor in when and how patients are treated. http://medicalxpress.com/news/2012-07-tumor-cells-cancer.html Cancer Fri, 27 Jul 2012 15:42:36 EST news262622533 Researchers at Albert Einstein College of Medicine of Yeshiva University have found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases that are common among the elderly and that can progress to acute leukemia. The findings could lead to targeted therapies against MDS and prevent MDS-related cancers. The study is published today in the online edition of the journal Blood. http://medicalxpress.com/news/2012-07-myelodysplastic-syndromes-mds-linked-abnormal.html Medical research Mon, 02 Jul 2012 04:06:02 EST news260420753 Cells that die naturally generate a lot of internal debris that can trigger the immune system to attack the body, leading to diseases such as lupus. http://medicalxpress.com/news/2012-02-natural-method-cellular-debris-lupus.html Immunology Fri, 24 Feb 2012 04:40:01 EST news249280333 Initial results of a multicenter study coordinated by researchers at Fred Hutchinson Cancer Research Center indicates that two investigational urine-based biomarkers are associated with prostate cancers that are likely to be aggressive and potentially life-threatening among men who take a "watchful waiting," or active-surveillance approach to manage their disease. Ultimately, these markers may lead to the development of a urine test that could complement prostate biopsy for predicting disease aggressiveness and progression. http://medicalxpress.com/news/2012-02-urine-high-risk-prostate-cancer-men.html Cancer Thu, 02 Feb 2012 13:06:15 EST news247410323 Cholesterol-lowering statins seem to keep breast cancer at bay in some patients. Now researchers reporting in the January 20th issue of the journal Cell, a Cell Press publication, provide clues about how statins might yield those unexpected benefits. The findings also suggest that mutations in a single gene could be used to identify tumors likely to respond to statin therapy. http://medicalxpress.com/news/2012-01-cholesterol-lowering-statins-cancer.html Cancer Thu, 19 Jan 2012 13:05:42 EST news246200732 The presence of circulating tumor cells in the blood appears to have no relationship to survival in women who have just been diagnosed with inflammatory breast cancer, according to new research from Fox Chase Cancer Center. However, the research shows that these stray tumor cells may signal that the disease has spread to other parts of the body, even before imaging reveals any metastases. The results will be presented on Friday, December 9 at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. http://medicalxpress.com/news/2011-12-circulating-tumor-cells-linked-survival.html Inflammatory disorders Fri, 09 Dec 2011 08:43:26 EST news242642333 Non-invasive imaging detects prostate cancer earlier than ever before, but can't accurately distinguish between malignant and benign disease. According to Lawson Health Research Institute's Drs. John Lewis and Len Luyt, a new molecular imaging probe could be the answer. http://medicalxpress.com/news/2011-12-imaging-agent-appetite-dangerous-prostate.html Cancer Thu, 08 Dec 2011 12:11:01 EST news242568644 In geriatric medicine, the adage that age is just a number holds true. New research from Wake Forest Baptist Medical Center uses a simple assessment tool to determine how well older adults diagnosed with acute myelogenous leukemia (AML) can handle treatment. http://medicalxpress.com/news/2011-10-bedside-outcomes-older-cancer-patients.html Cancer Wed, 26 Oct 2011 11:06:40 EST news238845991 Treating women with early stage breast cancer with a combination of chemotherapy and the molecularly targeted drug Herceptin significantly increases survival in patients with a specific genetic mutation that results in very aggressive disease, a researcher with UCLA's Jonsson Comprehensive Cancer Center reported Wednesday. http://medicalxpress.com/news/2011-10-survival-early-stage-breast-cancer.html Cancer Wed, 05 Oct 2011 17:54:07 EST news237056037 Researchers at Cold Spring Harbor Laboratory (CSHL) have identified an enzyme that appears to be a significant regulator of breast cancer development. Called PTPN23, the enzyme is a member of a family called protein tyrosine phosphatases, or PTPs, that plays a fundamental role in switching cell signaling on and off. http://medicalxpress.com/news/2011-06-enzyme-important-aggressive-breast-cancer.html Genetics Thu, 30 Jun 2011 13:37:13 EST news228659818 A new study from Harvard School of Public Health (HSPH) and University of California, San Francisco, researchers suggests that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. A link also was found between smoking at the time of prostate cancer diagnosis and aggressive prostate cancer, overall mortality (death) and cardiovascular disease mortality. http://medicalxpress.com/news/2011-06-prostate-cancer-recurrence-death.html Cancer Tue, 21 Jun 2011 16:26:17 EST news227892240