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(Medical Xpress)—For the past 70 years, androgen deprivation therapy (ADT) has been the standard treatment for men diagnosed with late-stage prostate cancer. http://medicalxpress.com/news/2013-06-approach-late-stage-prostate-cancer.html Genetics Fri, 14 Jun 2013 07:00:06 EST news290411998 Dr. Jung-Mo Ahn, associate professor of chemistry at The University of Texas at Dallas, has designed and synthesized a novel small molecule that might become a large weapon in the fight against prostate cancer. http://medicalxpress.com/news/2013-05-small-molecule-big-impact-cancer.html Cancer Tue, 28 May 2013 16:18:04 EST news288976675 A new study on prostate cancer describes a novel class of drugs developed by UT Southwestern Medical Center researchers that interrupts critical signaling needed for prostate cancer cells to grow. http://medicalxpress.com/news/2013-05-class-drugs-prostate-cancers.html Cancer Tue, 28 May 2013 15:14:04 EST news288972838 Estrogen and progesterone receptors, and the gene HER2 – these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors. http://medicalxpress.com/news/2013-04-evidence-androgen-breast-cancer.html Cancer Wed, 10 Apr 2013 09:16:19 EST news284804172 Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer. http://medicalxpress.com/news/2013-04-characterises-prostate-cancer.html Cancer Thu, 04 Apr 2013 20:00:01 EST news284317508 Hormonal therapies can help control advanced prostate cancer for a time. However, for most men, at some point their prostate cancer eventually stops responding to further hormonal treatment. This stage of the disease is called androgen-insensitive or castration-resistant prostate cancer. In a study published March 18 in Cancer Cell, a team led by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) found a mechanism at play in androgen-insensitive cells that enables them to survive treatment. They discovered that a protein called Siah2 keeps a portion of androgen receptors constantly active in these prostate cancer cells. Androgen receptors—sensors that receive and respond to the hormone androgen—play a critical role in prostate cancer development and progression. http://medicalxpress.com/news/2013-03-prostate-tumors-resist-treatmentand.html Cancer Mon, 18 Mar 2013 12:00:04 EST news282825539 Prostate cancer is often considered an elderly man's disease, and little is known about the approximately 2% of cases that arise in men who are aged 50 years or younger. Research published in the February 11th issue of the Cell Press journal Cancer Cell uncovers the genetic origin of such early-onset prostate cancer. The findings could help in the development of new diagnostic, prognostic, therapeutic, and prevention strategies for the disease. http://medicalxpress.com/news/2013-02-genetic-root-early-onset-prostate-cancer.html Cancer Mon, 11 Feb 2013 12:00:05 EST news279803644 The first-ever comprehensive study of prostate cancer tissue has revealed a completely new gene network driving the disease in patients who have stopped responding to standard hormone treatment, according to Cancer Research UK research published today in Cancer Cell. http://medicalxpress.com/news/2012-12-world-first-tissue-re-shape-future-advanced.html Cancer Fri, 21 Dec 2012 06:39:37 EST news275294369 Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. http://medicalxpress.com/news/2012-12-culprit-castration-resistant-prostate-cancer.html Cancer Thu, 13 Dec 2012 14:19:08 EST news274630741 Breast cancers are defined by their drivers – estrogen and progesterone receptors (ER and PR) and HER2 are the most common, and there are drugs targeting each. When breast cancer has an unknown driver, it also has fewer treatment options – this aggressive form of breast cancer without ER, PR or HER2, which was thought not to be driven by hormones, is known as triple negative. A decade ago, work at the University of Colorado Cancer Center added another potential driver to the list – the androgen receptor – and this week marks a major milestone in a clinical trial targeting this cause of breast cancer growth. http://medicalxpress.com/news/2012-12-clinical-trial-war-breast-cancer.html Cancer Mon, 03 Dec 2012 12:00:02 EST news273753881 By studying a specific part of the male DNA, it may be possible to refine the interpretation of PSA tests. This would reduce the risk of men being treated for prostate cancer unnecessarily. http://medicalxpress.com/news/2012-10-men-genes-psa.html Cancer Tue, 30 Oct 2012 12:10:46 EST news270817756 Deciding the ideal treatment for patients with metastatic prostate cancer that stops responding to initial therapy could be guided by certain analyses of cancer cells isolated from the patients' blood, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-10-noninvasive-assay-treatment-response-patients.html Cancer Tue, 23 Oct 2012 12:15:05 EST news270213278 A study by researchers from Emory University and Indiana University found that the beneficial effects daily exercise can have on the regeneration of nerves also require androgens such as testosterone in both males and females. It is the first report of both androgen-dependence of exercise on nerve regeneration and of an androgenic effect of exercise in females. http://medicalxpress.com/news/2012-10-role-androgens-testosterone-nerve.html Neuroscience Mon, 15 Oct 2012 12:00:03 EST news269499339 The power of taxane-based chemotherapy drugs are misunderstood and potentially underestimated, according to researchers at Weill Cornell Medical College in the September 15 issue of the journal Cancer Research. http://medicalxpress.com/news/2012-09-reveal-underlying-mechanism-powerful-chemotherapy.html Cancer Mon, 17 Sep 2012 17:03:33 EST news267120203 Cancer Research UK scientists have revealed a completely new route by which male androgen hormones fuel the growth of prostate cancer, raising the prospect that existing drugs could be used to treat the disease. http://medicalxpress.com/news/2012-08-scientists-key-piece-prostate-cancer.html Cancer Tue, 14 Aug 2012 04:38:05 EST news264137865 A small, naturally occurring nucleic acid sequence, called a microRNA, known to regulate a number of different cancers, appears to alter the activity of the androgen receptor, which plays a critical role in prostate cancer. Directly targeting microRNA-125b to block androgen receptor activity represents a novel approach for treating castrate-resistant prostate cancer. This promising new strategy for improving the effectiveness of anti-androgenic and other hormonal therapies is described in an article in BioResearch Open Access. http://medicalxpress.com/news/2012-07-therapeutic-prostate-cancer.html Cancer Tue, 17 Jul 2012 11:27:26 EST news261743239 An experimental medication safely increases muscle strength and physical functioning among cancer patients with low testosterone levels, a new drug study finds. The results will be presented at The Endocrine Society's 94th Annual Meeting in Houston. http://medicalxpress.com/news/2012-06-experimental-drug-muscle-strength-male.html Medical research Mon, 25 Jun 2012 09:31:33 EST news259835471 A U.S patent issued today to the University of Rochester and two other entities for the use of compounds related to a popular spice in the fight against cancer, acne, baldness, and other medical conditions. http://medicalxpress.com/news/2012-06-capability-curry-component-disease-merits.html Medical research Tue, 12 Jun 2012 12:42:32 EST news258723742 Patients with castration-resistant prostate cancer had limited side effects and in many cases a drop in prostate-specific antigen expression with galeterone (TOK-001), a small-molecule oral drug, according to phase I data presented at the AACR Annual Meeting 2012, held here March 31 - April 4. http://medicalxpress.com/news/2012-04-early-clinical-galeterone-safe-effective.html Cancer Sun, 01 Apr 2012 05:57:35 EST news252478648 Could blocking a testosterone receptor lead to a new way to treat an aggressive form of breast cancer? That's a question researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) are exploring. Preliminary results of a Mayo Clinic - TGen collaborative study shows the testosterone receptor may be a potential target to attack in treating triple negative breast cancer (TNBC). http://medicalxpress.com/news/2012-03-role-testosterone-triple-negative-breast.html Cancer Fri, 23 Mar 2012 09:29:27 EST news251713731 Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson's Kimmel Cancer Center suggests. http://medicalxpress.com/news/2012-02-curry-spice-component-prostate-tumor.html Cancer Fri, 10 Feb 2012 11:00:01 EST news248093404 Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. http://medicalxpress.com/news/2012-02-prostate-cancer-drug.html Cancer Mon, 06 Feb 2012 15:00:16 EST news247755688 A new drug, MDV3100, is improving the survival rate in men with advanced prostate cancer, results of a large, phase III clinical trial show. The drug is designed to block a type of cellular receptor that drives progression of prostate cancer. Based on the strength of the data from the phase III trial, it is anticipated that the biopharmaceutical company Medivation, which licensed MDV3100, will file a new drug application with the Food and Drug Administration later this year. http://medicalxpress.com/news/2012-02-drug-survival-patients-drug-resistant-prostate.html Cancer Wed, 01 Feb 2012 03:06:15 EST news247287958 Although it sounds like a case of gender confusion on a molecular scale, the male hormone androgen spurs the growth of some breast tumors in women. In a new study, scientists at Dana-Farber Cancer Institute provide the first details of the cancer cell machinery that carries out the hormone's relentless growth orders. http://medicalxpress.com/news/2011-07-breast-cancers-fueled-estrogen.html Cancer Mon, 11 Jul 2011 12:46:48 EST news229607190 The ratio between the second and fourth digits is linked to stretched penile length according to a study published online this week in Asian Journal of Andrology. This finding suggests that digit ratio can predict adult penile size and that the effects of prenatal testosterone may in part explain the differences in adult penile length. http://medicalxpress.com/news/2011-07-finger-ratio-penile-length.html Other Tue, 05 Jul 2011 03:59:35 EST news229057146 Cancer is crafty. When one avenue driving its growth is blocked by drugs targeting that path, the malignancy often creates a detour, finding an alternative route to get around the roadblock. http://medicalxpress.com/news/2011-06-prostate-cancer-hormone-therapy-survival.html Cancer Tue, 14 Jun 2011 15:06:34 EST news227282778