http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A study by researchers from Emory University and Indiana University found that the beneficial effects daily exercise can have on the regeneration of nerves also require androgens such as testosterone in both males and females. It is the first report of both androgen-dependence of exercise on nerve regeneration and of an androgenic effect of exercise in females. http://medicalxpress.com/news/2012-10-role-androgens-testosterone-nerve.html Neuroscience Mon, 15 Oct 2012 12:00:03 EST news269499339 Scientists have discovered two separate genetic 'signatures' for prostate cancer that appear to be able to predict the severity of the disease, leading to hopes that in future, accuracy of prognosis and treatment of the disease could be greatly improved. Two Articles published in The Lancet Oncology reveal distinctive patterns of RNA—the genetic material that helps turn DNA into proteins—which appear to be able to predict whether patients have an aggressive prostate cancer, or whether they have a milder form of the disease. http://medicalxpress.com/news/2012-10-scientists-genetic-signatures-aggressive-prostate.html Cancer Mon, 08 Oct 2012 18:30:01 EST news268913570 Bladder cancer patients whose tumors express high levels of the protein CD24 have worse prognoses than patients with lower CD24. A University of Colorado Cancer Center study published today in the Proceedings of the National Academy of Sciences shows that CD24 expression may depend on androgens – and that anti-androgen therapies like those currently used to treat prostate cancer may benefit bladder cancer patients. http://medicalxpress.com/news/2012-09-prostate-cancer-bladder-patients-benefit.html Cancer Mon, 24 Sep 2012 15:00:06 EST news267704662 The power of taxane-based chemotherapy drugs are misunderstood and potentially underestimated, according to researchers at Weill Cornell Medical College in the September 15 issue of the journal Cancer Research. http://medicalxpress.com/news/2012-09-reveal-underlying-mechanism-powerful-chemotherapy.html Cancer Mon, 17 Sep 2012 17:03:33 EST news267120203 Results of a phase III clinical trial of the drug Enzalutamide, published yesterday in the New England Journal of Medicine, show the drug extends life by an average five months in the most advanced stages of prostate cancer. http://medicalxpress.com/news/2012-08-enzalutamide-months-survival-late-stage-prostate.html Cancer Thu, 16 Aug 2012 10:33:22 EST news264331988 Cancer Research UK scientists have revealed a completely new route by which male androgen hormones fuel the growth of prostate cancer, raising the prospect that existing drugs could be used to treat the disease. http://medicalxpress.com/news/2012-08-scientists-key-piece-prostate-cancer.html Cancer Tue, 14 Aug 2012 04:38:05 EST news264137865 Studies have shown that the offspring of mothers on a low-protein diet are more likely to develop hypertension as adults. Now, Drs. Gao, Yallampalli, and Yallampalli of the University of Texas Medical Branch at Galveston report that in rats, the high maternal testosterone levels associated with a low-protein diet are caused by reduced activity of an enzyme that inactivates testosterone, allowing more testosterone to reach the fetus and increase the offspring's susceptibility to adulthood hypertension. http://medicalxpress.com/news/2012-07-low-protein-diet-predisposes-offspring-adulthood.html Medical research Wed, 25 Jul 2012 15:00:01 EST news262439498 A small, naturally occurring nucleic acid sequence, called a microRNA, known to regulate a number of different cancers, appears to alter the activity of the androgen receptor, which plays a critical role in prostate cancer. Directly targeting microRNA-125b to block androgen receptor activity represents a novel approach for treating castrate-resistant prostate cancer. This promising new strategy for improving the effectiveness of anti-androgenic and other hormonal therapies is described in an article in BioResearch Open Access. http://medicalxpress.com/news/2012-07-therapeutic-prostate-cancer.html Cancer Tue, 17 Jul 2012 11:27:26 EST news261743239 An experimental medication safely increases muscle strength and physical functioning among cancer patients with low testosterone levels, a new drug study finds. The results will be presented at The Endocrine Society's 94th Annual Meeting in Houston. http://medicalxpress.com/news/2012-06-experimental-drug-muscle-strength-male.html Medical research Mon, 25 Jun 2012 09:31:33 EST news259835471 (HealthDay) -- Testosterone replacement therapy (TRT) appears to be safe and does not increase the incidence of prostate cancer, according to a study published online June 6 in The Journal of Sexual Medicine. http://medicalxpress.com/news/2012-06-testosterone-therapy-prostate-cancer-incidence.html Cancer Fri, 15 Jun 2012 14:00:01 EST news258983724 A U.S patent issued today to the University of Rochester and two other entities for the use of compounds related to a popular spice in the fight against cancer, acne, baldness, and other medical conditions. http://medicalxpress.com/news/2012-06-capability-curry-component-disease-merits.html Medical research Tue, 12 Jun 2012 12:42:32 EST news258723742 Many breast cancers depend on hormones including estrogen or progesterone for their survival and proliferation. Eight years of lab work at the University of Colorado Cancer Center and elsewhere suggest that the androgen (AR) receptor is an additional hormonal target in many breast cancers. Block AR+ breast cancer's ability to access androgen and you block the cancer's ability to survive. http://medicalxpress.com/news/2012-06-drug-breast-cancer.html Cancer Mon, 04 Jun 2012 09:11:16 EST news258019856 (HealthDay) -- Got hair? If you don't, you might have a higher risk of prostate cancer, a preliminary study suggests. http://medicalxpress.com/news/2012-05-bald-men-higher-prostate-cancer.html Cancer Tue, 22 May 2012 13:30:01 EST news256911309 A hormone-depleting drug approved last year for the treatment of metastatic prostate cancer can help eliminate or nearly eliminate tumors in many patients with aggressive cancers that have yet to spread beyond the prostate, according to a clinical study to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO), June 1-5, in Chicago. http://medicalxpress.com/news/2012-05-hormone-depleting-drug-localized-high-risk-prostate.html Cancer Wed, 16 May 2012 18:00:05 EST news256405573 Low levels of testosterone in men could increase their risk of developing diabetes, a study suggests. http://medicalxpress.com/news/2012-05-testosterone-diabetes-men.html Medical research Fri, 04 May 2012 10:50:06 EST news255345381 (HealthDay) -- The highest average change in bone mineral density (BMD) occurs during early treatment of nonmetastatic, hormone-sensitive prostate cancer in men receiving intermittent androgen deprivation therapy (ADT), according to research published online April 9 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-04-bmd-loss-early-androgen-deprivation.html Cancer Wed, 11 Apr 2012 12:40:01 EST news253365692 Patients with castration-resistant prostate cancer had limited side effects and in many cases a drop in prostate-specific antigen expression with galeterone (TOK-001), a small-molecule oral drug, according to phase I data presented at the AACR Annual Meeting 2012, held here March 31 - April 4. http://medicalxpress.com/news/2012-04-early-clinical-galeterone-safe-effective.html Cancer Sun, 01 Apr 2012 05:57:35 EST news252478648 Androgen suppression – the inhibition of testosterone and other male hormones – is a routine therapy for prostate cancer. Unfortunately, it can dramatically reduce the quality of patients' sex lives and, more importantly, lead to cancer recurrence in a more deadly androgen-independent form. http://medicalxpress.com/news/2012-03-androgen-suppression.html Cancer Tue, 27 Mar 2012 14:51:33 EST news252078674 Could blocking a testosterone receptor lead to a new way to treat an aggressive form of breast cancer? That's a question researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) are exploring. Preliminary results of a Mayo Clinic - TGen collaborative study shows the testosterone receptor may be a potential target to attack in treating triple negative breast cancer (TNBC). http://medicalxpress.com/news/2012-03-role-testosterone-triple-negative-breast.html Cancer Fri, 23 Mar 2012 09:29:27 EST news251713731 Androgen enhances replication of hepatitis B virus (HBV), rendering males more vulnerable than females to this virus, according to research published in the February Journal of Virology. http://medicalxpress.com/news/2012-02-androgen-boosts-hepatitis-virus-replication.html Diseases, Conditions, Syndromes Thu, 16 Feb 2012 05:23:41 EST news248592211 Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson's Kimmel Cancer Center suggests. http://medicalxpress.com/news/2012-02-curry-spice-component-prostate-tumor.html Cancer Fri, 10 Feb 2012 11:00:01 EST news248093404 Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. http://medicalxpress.com/news/2012-02-prostate-cancer-drug.html Cancer Mon, 06 Feb 2012 15:00:16 EST news247755688 A new drug, MDV3100, is improving the survival rate in men with advanced prostate cancer, results of a large, phase III clinical trial show. The drug is designed to block a type of cellular receptor that drives progression of prostate cancer. Based on the strength of the data from the phase III trial, it is anticipated that the biopharmaceutical company Medivation, which licensed MDV3100, will file a new drug application with the Food and Drug Administration later this year. http://medicalxpress.com/news/2012-02-drug-survival-patients-drug-resistant-prostate.html Cancer Wed, 01 Feb 2012 03:06:15 EST news247287958 Stockholm, Sweden: Men with prostate cancer that has spread to other parts of the body and that is resistant to hormone therapy suffer less from fatigue if they are treated with a combination of abiraterone acetate and prednisone, according to results from a phase III clinical trial presented today. http://medicalxpress.com/news/2011-09-abiraterone-acetate-fatigue-prostate-cancer.html Cancer Sun, 25 Sep 2011 13:27:28 EST news236176033 Although it sounds like a case of gender confusion on a molecular scale, the male hormone androgen spurs the growth of some breast tumors in women. In a new study, scientists at Dana-Farber Cancer Institute provide the first details of the cancer cell machinery that carries out the hormone's relentless growth orders. http://medicalxpress.com/news/2011-07-breast-cancers-fueled-estrogen.html Cancer Mon, 11 Jul 2011 12:46:48 EST news229607190 The ratio between the second and fourth digits is linked to stretched penile length according to a study published online this week in Asian Journal of Andrology. This finding suggests that digit ratio can predict adult penile size and that the effects of prenatal testosterone may in part explain the differences in adult penile length. http://medicalxpress.com/news/2011-07-finger-ratio-penile-length.html Other Tue, 05 Jul 2011 03:59:35 EST news229057146 Cancer is crafty. When one avenue driving its growth is blocked by drugs targeting that path, the malignancy often creates a detour, finding an alternative route to get around the roadblock. http://medicalxpress.com/news/2011-06-prostate-cancer-hormone-therapy-survival.html Cancer Tue, 14 Jun 2011 15:06:34 EST news227282778 A new targeted therapy for prostate cancer halts tumor growth in animals with advanced prostate cancer that is resistant to hormone therapy, a new study finds. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston. http://medicalxpress.com/news/2011-06-cancer-therapy-prostate-tumor-cells.html Cancer Mon, 06 Jun 2011 09:39:51 EST news226571975