http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children's Research Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called multisystem proteinopathy) and one case of the familial form of amyotrophic lateral sclerosis (ALS). http://medicalxpress.com/news/2013-03-proteins-mutations-prion-like-segments-candidates.html Medical research Sun, 03 Mar 2013 13:00:09 EST news281520692 The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine on December 10th. These findings may help explain why these bacteria cause millions of localized infections, but more serious, systemic blood infections are rare. http://medicalxpress.com/news/2012-12-antibody.html Medical research Mon, 10 Dec 2012 12:00:20 EST news274359207 ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute. http://medicalxpress.com/news/2012-06-probing-mechanism-adam28-mediated-cancer-metastasis.html Cancer Fri, 08 Jun 2012 18:07:58 EST news258397672 Researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with Nurses' Health Study investigators have shown that levels of certain related proteins found in blood are associated with a greatly reduced risk for developing type 2 diabetes up to a decade or more later. The findings, published today in the online edition of Diabetes, could open a new front in the war against diabetes. http://medicalxpress.com/news/2012-05-blood-factors-diabetes.html Diabetes Thu, 03 May 2012 14:20:01 EST news255272099 A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry. http://medicalxpress.com/news/2012-04-cancer-fighting-goodness-cholesterol.html Cancer Thu, 19 Apr 2012 16:20:02 EST news254070769 Several genes have been linked to ALS, with one of the most recent called FUS. Two new studies in PLoS Biology, one from the University of Pennsylvania School of Medicine, and the other from colleagues at Brandeis University, both examined FUS biology in yeast and found that defects in RNA biology may be central to how FUS contributes to ALS, or Lou Gehrig's disease. These findings point to new targets for developing drugs. http://medicalxpress.com/news/2011-04-mutated-protein-lou-gehrigs-disease.html Genetics Tue, 26 Apr 2011 17:35:35 EST news223058108