http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers. Results of the study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Sheba Medical Center in Tel Hashomer, Israel, will be presented during the American Society of Clinical Oncology's annual meeting in Chicago in early June (Abstract #11024). http://medicalxpress.com/news/2013-05-parp-inhibitor-pancreatic-prostate-cancers.html Cancer Wed, 15 May 2013 18:00:01 EST news287856979 Patients with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found between patients with BRCA2 mutations and those without a BRCA mutation, according to data from a large Dutch study presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-patients-brca1-mutations-brca2-poorer.html Cancer Tue, 09 Apr 2013 08:00:01 EST news284710874 Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in the Jan. 16 issue of The Breast Journal. http://medicalxpress.com/news/2013-03-genetic-strategies-young-black-female.html Cancer Thu, 21 Mar 2013 11:47:54 EST news283085136 (HealthDay)—Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study. http://medicalxpress.com/news/2013-02-gene-mutation-benefit-ovarian-cancer.html Cancer Wed, 20 Feb 2013 03:40:02 EST news280552931 A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2013-01-presence-brca-mutations.html Cancer Tue, 22 Jan 2013 13:00:01 EST news278073437 Following BRCA testing, many women who are non-BRCA carriers undergo risk-reducing procedures and additional ovarian cancer screenings, despite limited data to determine the effectiveness of these interventions among the general population, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication. http://medicalxpress.com/news/2012-12-reduction-screening-ovarian-cancer-women.html Cancer Mon, 17 Dec 2012 16:00:06 EST news274966977 (Medical Xpress)—Ongoing research at the Methodist Cancer Center could reveal whether metastatic breast cancer patients with BRCA gene mutations are particularly responsive to a drug regimen that includes Veliparib, an investigational drug believed to hamper cancer cells. http://medicalxpress.com/news/2012-09-brca1-brca2-mutation-treatment-option.html Cancer Thu, 20 Sep 2012 07:45:20 EST news267345911 Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive breast cancers, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-09-parp-inhibitors-clinical-her2-positive-breast.html Cancer Mon, 17 Sep 2012 00:20:01 EST news267018005 (Medical Xpress) -- At age 47, Melanie Lemons has already had her ovaries removed. With a few clicks of her computer’s mouse, she can see her estimated chance of survival if she has her breasts removed as well. http://medicalxpress.com/news/2012-04-online-tool-brca-mutations-options.html Cancer Mon, 09 Apr 2012 07:36:38 EST news253175773 Women who inherit the cancer genes BRCA1 or BRCA2 from their paternal lineage may get a diagnosis a decade earlier than those women who carry the cancer genes from their mother and her ancestors, according to a new study by researchers at the North Shore-LIJ Health System's Monter Cancer Center in Lake Success, NY. The findings were reported on Thursday, Dec. 8, at the San Antonio Breast Cancer Symposium. http://medicalxpress.com/news/2011-12-gene-inheritance-patterns-age-diagnosis.html Cancer Mon, 12 Dec 2011 09:31:44 EST news242904694 Women with the BRCA1 or BRCA2 gene mutations, which are linked to a very high risk of breast and ovarian cancer, can safely take hormone-replacement therapy (HRT) to mitigate menopausal symptoms after surgical removal of their ovaries, according to new research from the Perelman School of Medicine at the University of Pennsylvania which will be presented Monday, June 6 during the American Society for Clinical Oncology's annual meeting (Abstract #1501). Results of the prospective study indicated that women with BRCA mutations who had their ovaries removed and took short-term HRT had a decrease in the risk of developing breast cancer. http://medicalxpress.com/news/2011-06-women-brca-mutations-hormone-replacement-therapy.html Cancer Wed, 01 Jun 2011 15:03:00 EST news226159355