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Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer. http://medicalxpress.com/news/2013-04-pathway-tamoxifen-aggressive-breast-cancer.html Cancer Tue, 23 Apr 2013 12:47:35 EST news285940047 The U.S. Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones. http://medicalxpress.com/news/2013-02-fda-breast-cancer-drug.html Cancer Fri, 22 Feb 2013 10:32:24 EST news280751538 Dartmouth scientists showed that more than half of all the SNPs associated with breast cancer risk are located in distant regions and bound by FOXA1, a protein required for estrogen receptor-α (ER) function according to a paper published in the journal Nature Genetics in November. http://medicalxpress.com/news/2013-01-snps-breast-cancer-affinity-factor.html Cancer Wed, 23 Jan 2013 16:17:02 EST news278180216 A new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse model of Duchenne muscular dystrophy (DMD). At present, no treatment is known to produce long-term improvement of the symptoms in boys with DMD, a debilitating muscular disorder that is characterized by progressive muscle wasting, respiratory and cardiac impairments, paralysis, and premature death. This study will be published in the February 2013 issue of The American Journal of Pathology. http://medicalxpress.com/news/2013-01-tamoxifen-ameliorates-symptoms-duchenne-muscular.html Diseases, Conditions, Syndromes Tue, 15 Jan 2013 00:00:02 EST news277383672 For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center and the Austrian Breast and Colorectal Cancer Study Group provides evidence that genetic differences in the enzyme CYP2D6 play a key role in how well tamoxifen works. http://medicalxpress.com/news/2012-12-ability-metabolize-tamoxifen-affects-breast.html Cancer Thu, 27 Dec 2012 13:16:43 EST news275836596 A groundbreaking clinical trial involving the breast cancer drug tamoxifen should prompt certain breast cancer patients to reconsider their treatment options, according to Loyola University Medical Center breast cancer specialist Dr. Kathy Albain. http://medicalxpress.com/news/2012-12-tamoxifen-trial-prompt-breast-cancer.html Cancer Thu, 06 Dec 2012 13:04:46 EST news274021477 (HealthDay) —Taking the breast cancer drug tamoxifen for a decade, instead of the standard five years, further reduces the long-term chances of recurrence and risk of dying from the disease, new British research suggests. http://medicalxpress.com/news/2012-12-years-tamoxifen.html Cancer Wed, 05 Dec 2012 19:10:02 EST news273946660 Researchers from Helsinki Institute for Information Technology HIIT and Institute for Molecular Medicine Finland FIMM have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells. Harnessing genomic profiles of cells in choosing the best treatment is considered the holy grail of personalised medicine. http://medicalxpress.com/news/2012-11-excel-cancer-drug-sensitivity.html Cancer Mon, 19 Nov 2012 10:45:45 EST news272544339 A new study shows that the lack of a certain gene occurs in almost 28 percent of human breast cancers, playing a role in some 60,000 breast cancer cases in the United States and 383,000 worldwide this year. http://medicalxpress.com/news/2012-08-gene-deletion-quarter-breast-cancers.html Genetics Wed, 15 Aug 2012 04:17:35 EST news264223029 A new method of delivering a commonly used breast cancer drug could result in considerably less time spent in hospital for some women undergoing breast cancer treatment, according to the results of a Phase 3 trial published Online First in The Lancet Oncology. http://medicalxpress.com/news/2012-08-herceptin-delivery-method-vastly-breast.html Cancer Wed, 08 Aug 2012 18:30:01 EST news263660969 Women using fertility drugs who did not conceive a 10-plus week pregnancy were at a statistically significant reduced risk of breast cancer compared to nonusers; however, women using the drugs who conceived a 10-plus week pregnancy had a statistically significant increased risk of breast cancer compared to unsuccessfully treated women, but a comparable risk to nonusers, according to a study published July 6 in the Journal of The National Cancer Institute. http://medicalxpress.com/news/2012-07-fertility-drug-usage-cancer.html Cancer Fri, 06 Jul 2012 16:00:01 EST news260799723 French health authorities said Monday that nearly 8,000 French women had followed a government recommendation to have faulty breast implants that sparked a global health scare removed. http://medicalxpress.com/news/2012-06-french-women-faulty-breast-implants.html Surgery Mon, 04 Jun 2012 15:22:34 EST news258042148 Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments. http://medicalxpress.com/news/2012-04-scientists-breast-cancer-genes-rewrite.html Cancer Wed, 18 Apr 2012 13:00:15 EST news253972596 University of Manchester scientists are developing a test that will help identify patients who will benefit from a new breast cancer treatment, thanks to a research grant worth almost £180,000 from Breast Cancer Campaign. http://medicalxpress.com/news/2012-01-scientists-breast-cancer-treatment.html Cancer Mon, 23 Jan 2012 05:53:43 EST news246520413 The largest study to investigate the tolerability of the breast cancer drug tamoxifen in male breast cancer patients has shown that men stop taking their prescribed therapy early because of problems with side effects caused by the drug. http://medicalxpress.com/news/2011-11-male-breast-cancer-patients-tamoxifen.html Cancer Wed, 16 Nov 2011 05:16:22 EST news240642975 Researchers exploring why some women who take a common breast cancer drug develop serious joint pain have eliminated two possible causes: inflammatory arthritis and autoimmune disease. Because of these findings, researchers say women should be encouraged to continue taking the medication to gain its full benefit. http://medicalxpress.com/news/2011-11-joint-pain-linked-commonly-breast.html Cancer Fri, 11 Nov 2011 11:54:39 EST news240234842 A protein in the nucleus of breast cancer cells that plays a role in fueling the growth of aggressive tumors may be a good target for new drugs, reports a research team at the Duke Cancer Institute. http://medicalxpress.com/news/2011-10-protein-fuels-lethal-breast-cancer.html Cancer Mon, 17 Oct 2011 12:49:32 EST news238074555 (Medical Xpress) -- The first study to investigate the effect of the breast cancer drug trastuzumab (Herceptin) on heart and vascular function in elderly patients has found that it increases the risk of heart problems, particularly in women with a history of heart disease, diabetes or both. http://medicalxpress.com/news/2011-08-trastuzumab-heart-problems-elderly-history.html Cancer Wed, 10 Aug 2011 02:43:32 EST news232162973 Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine. http://medicalxpress.com/news/2011-05-scientists-drug-breast-cancer.html Cancer Sun, 22 May 2011 13:00:22 EST news225287182 Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids—abundant in fish—could be a safe and beneficial booster for tamoxifen therapy. http://medicalxpress.com/news/2011-04-fish-oil-boosts-responses-breast.html Cancer Wed, 06 Apr 2011 09:26:48 EST news221300794