http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. (Medical Xpress)—Cancer cells that can break out of a tumor and invade other organs are more aggressive and nimble than nonmalignant cells, according to a new multi-institutional nationwide study. These cells exert greater force on their environment and can more easily maneuver small spaces. http://medicalxpress.com/news/2013-04-physicists-biologists-expose-cancer.html Cancer Fri, 26 Apr 2013 14:39:39 EST news286205968 Melbourne scientists have discovered how female steroid hormones can make dramatic changes to the genetic material in breast cells, changes that could potentially lead to breast cancer. http://medicalxpress.com/news/2013-01-hormones-breast-genetic-material.html Medical research Thu, 31 Jan 2013 12:00:01 EST news278853837 The DNA mutations that accumulate over time as women age are not the sole contributor to the higher frequency of breast cancer in women over 50, Mark LaBarge, PhD, a researcher at Lawrence Berkeley National Laboratory (LBNL) reported on Dec. 17 in a presentation at the American Society for Cell Biology Annual Meeting in San Francisco. http://medicalxpress.com/news/2012-12-progenitor-cell-population-breast-overlooked.html Cancer Mon, 17 Dec 2012 13:00:09 EST news274961056 Researchers at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory have put the squeeze—literally—on malignant mammary cells to guide them back into a normal growth pattern. http://medicalxpress.com/news/2012-12-revert-breast-cancer-cells.html Cancer Mon, 17 Dec 2012 13:00:03 EST news274959117 (Medical Xpress)—A new study from Johns Hopkins researchers suggests that the lethal spread of breast cancer is as dependent on a tumor's protein-rich environment as on genetic changes inside tumor cells. http://medicalxpress.com/news/2012-10-breast-cancer-cells-enticed-tumorous.html Cancer Mon, 22 Oct 2012 13:07:00 EST news270129998 (Medical Xpress)—Scientists at Aston University and Russells Hall Hospital have discovered that an extract from a common plant in Pakistan may help cure breast cancer. http://medicalxpress.com/news/2012-08-cup-herbal-tea-breast-cancer.html Cancer Sat, 25 Aug 2012 14:33:56 EST news265123808 Scientists at Tulane University School of Medicine, led by Dr. James Antoon and Dr. Barbara Beckman, have characterized two drugs targeting sphingosine kinase (SK), an enzyme involved in cancer growth and metastasis. New treatments specifically attacking cancer cells, but not normal ones, are critical in the fight against cancer. The results, which appear in the July 2012 issue of Experimental Biology and Medicine, demonstrate the role of SK in drug resistance and therapeutic potential of SK inhibitors. http://medicalxpress.com/news/2012-08-drug-resistant-cancer-inhibition-sphingosine.html Cancer Thu, 09 Aug 2012 11:38:44 EST news263731115 Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. http://medicalxpress.com/news/2012-07-protein-resistance-widely-anti-estrogen-drugs.html Cancer Mon, 02 Jul 2012 03:59:03 EST news260420323 In two back-to-back reports published online on 17 May in Cell, researchers have sequenced the genomes of 21 breast cancers and analysed the mutations that emerged during the tumours' development. The individual results are described below. http://medicalxpress.com/news/2012-05-comprehensive-genome-evolution-breast-cancers.html Cancer Thu, 17 May 2012 12:00:12 EST news256474382 Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research. http://medicalxpress.com/news/2012-04-protein-metastasis-human-breast-cancer.html Cancer Tue, 24 Apr 2012 10:25:05 EST news254481895 Although it's widely accepted that inflammation is a critical underlying factor in a range of diseases, including the progression of cancer, little is known about its role when normal cells become tumor cells. Now, scientists from the Florida campus of The Scripps Research Institute have shed new light on exactly how the activation of a pair of inflammatory signaling pathways leads to the transformation of normal breast cells to cancer cells. http://medicalxpress.com/news/2012-02-scientists-uncover-inflammatory-circuit-triggers.html Cancer Thu, 23 Feb 2012 13:09:33 EST news249224958 Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the standard model for predicting biological damage from ionizing radiation - the linear-no-threshold hypothesis or LNT - which holds that risk is directly proportional to dose at all levels of irradiation. http://medicalxpress.com/news/2011-12-impacts-dose.html Cancer Tue, 20 Dec 2011 13:12:59 EST news243609164 (Medical Xpress) -- Working with human breast cells, researchers at the Johns Hopkins Kimmel Cancer Center have shown how the inactivation of a single copy of the breast cancer gene BRCA1 leaves breast cells vulnerable to cancer by reducing their ability to repair DNA damage, causing genetic instability.  An inherited mutation in BRCA1 is the leading risk factor for hereditary breast cancer, prompting preventive mastectomies or close monitoring.  The new findings may aid development of drugs to prevent hereditary breast cancer and tools to identify women who benefit most from prophylactic treatments. http://medicalxpress.com/news/2011-12-scientists-brca1-cancer-gene-mutations.html Cancer Wed, 14 Dec 2011 06:57:14 EST news243068223 A new potential target to slow breast cancer tumor progression and metastasis has been identified by a team of researchers led by Dr. Richard Kremer from the Research Institute of the McGill University Health Centre (RI-MUHC). Complications in breast cancer patients are commonly caused by the spread of the disease through metastasis to other parts of the body, most often to the bones and lungs. These findings, published this week in the Journal of Clinical Investigation (JCI), suggest that a specific protein plays a key role in the progression of the disease outside of the initial tumor area. http://medicalxpress.com/news/2011-11-breast-cancer_1.html Cancer Thu, 10 Nov 2011 12:42:00 EST news240151312 Human breastmilk has the potential to help people suffering from diseases including Parkinson's disease and diabetes, according to a researcher at The University of Western Australia. http://medicalxpress.com/news/2011-10-breastmilk-natural-stem-cell-therapy.html Medical research Wed, 19 Oct 2011 08:44:40 EST news238232669 Identifying the cellular origins of breast cancer might lead to earlier diagnosis and more efficient management of the disease. New research led by Charlotte Kuperwasser of Tufts University School of Medicine (TUSM) has determined that common forms of breast cancer originate from breast cells known as luminal epithelial cells while rarer forms of breast cancer, such as metaplastic carcinomas, originate from basal epithelial cell types. The study was published online ahead of print this week in PNAS Early Edition as part of its breast cancer special feature. http://medicalxpress.com/news/2011-09-cellular-rare-breast-cancer.html Cancer Thu, 22 Sep 2011 11:27:14 EST news235909588 Could some women who naturally produce excess aromatase in their breasts have an increased risk of developing breast cancer? Results of a new animal study suggests that may be the case, say researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center. http://medicalxpress.com/news/2011-08-higher-estrogen-production-breast-confer.html Cancer Fri, 12 Aug 2011 12:34:07 EST news232371231 A protein activated by certain drugs already approved for treating Type II diabetes may slow or stop the spread of breast tumors. http://medicalxpress.com/news/2011-05-diabetic-drug-cancer.html Cancer Tue, 31 May 2011 16:20:00 EST news226077579 It is well known that the human body has a highly developed immune system to detect and destroy invading pathogens and tumor cells. Now, researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the body has a second line of defense against cancer – healthy cells. A new study shows that normal mammary epithelial cells, as they are developing, secrete interleukin 25, a protein known for its role in the immune system's response to inflammation, for the express purpose of killing nearby breast cancer cells. http://medicalxpress.com/news/2011-04-scientists-breast-cells-cancer.html Cancer Wed, 13 Apr 2011 14:44:35 EST news221924660