http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs. The research is published this week online in the Journal of Biological Chemistry. http://medicalxpress.com/news/2013-04-drug-metastatic-breast-cancer.html Cancer Thu, 11 Apr 2013 11:14:20 EST news284897653 Some breast tumor circulating cells in the bloodstream are marked by a constellation of biomarkers that identify them as those destined to seed the brain with a deadly spread of cancer, said researchers led by those at Baylor College of Medicine in a report that appears online in the journal Science Translational Medicine. http://medicalxpress.com/news/2013-04-signature-circulating-breast-tumor-cells.html Cancer Wed, 10 Apr 2013 14:00:02 EST news284818141 February 15, 2013 – Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening mode—an issue with profound implications for treatment. Now a group from The Scripps Research Institute (TSRI) has identified a mechanism through which mitochondria, the powerhouses of a cell, control tumor aggressiveness. Based on their findings, the team developed a simple treatment that inhibits cancer progression and prolongs life when tested in mice. http://medicalxpress.com/news/2013-02-scientists-approach-breast-cancer.html Cancer Fri, 15 Feb 2013 13:07:50 EST news280156049 A Kansas State University professor's research on breast cancer stem cells may help improve survival rates by preventing cancer recurrence and metastasis—the major causes of death among breast cancer patients. http://medicalxpress.com/news/2013-02-breast-cancer-treatment-tumor-cells.html Cancer Wed, 13 Feb 2013 11:30:04 EST news279973961 Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene promotes the progression and spread of breast cancer cells. The inactivation of a tumor suppression gene called Nischarin is among the mechanisms identified. The findings provide a new therapeutic target to block the function of Her2. The research was published in Cancer Research, OnlineFirst on January 21, 2013. http://medicalxpress.com/news/2013-01-drug-her-breast-cancer.html Cancer Tue, 22 Jan 2013 13:12:49 EST news278082689 Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9—which regulates cell migration, division and survival—has been linked to tumor invasion and metastasis in a variety of cancers. Researchers at Fox Chase Cancer Center have now shown that NEDD9 plays a surprising role in the early stages of breast tumor development by controlling the growth of progenitor cells that give rise to tumors. The findings, published in the journal Oncogene on January 14, 2013, could lead to personalized treatment strategies for women with breast cancer based on the levels of NEDD9 in their tumors. http://medicalxpress.com/news/2013-01-role-nedd9-gene-early-stages.html Cancer Mon, 14 Jan 2013 13:08:36 EST news277391310 Using advanced microscopes equipped with tissue-penetrating laser light, cancer imaging experts at Johns Hopkins have developed a promising, new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread. http://medicalxpress.com/news/2012-11-laser-light-breast-tumor-fiber-patterns.html Cancer Thu, 01 Nov 2012 14:30:15 EST news270999007 Racial and ethnic disparities in breast tumor aggressiveness might be explained by social factors that influence the developing tumor and place those in disadvantaged groups at higher risk for aggressive breast cancer, according to data presented at the Fifth AACR Conference on The Science of Cancer Health Disparities, held here Oct. 27-30, 2012. http://medicalxpress.com/news/2012-10-socioeconomic-disadvantage-linked-breast-cancer.html Cancer Tue, 30 Oct 2012 06:30:45 EST news270797388 (HealthDay)—Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence (IBTR), according to a study published in the Sept. 1 issue of Cancer. http://medicalxpress.com/news/2012-08-outcomes-similar-partial-breast-irradiation.html Cancer Fri, 24 Aug 2012 14:10:01 EST news265033685 A Rhode Island Hospital radiation oncologist says in a new editorial that research exploring the impact of radiotherapy in older women with low risk of breast cancer recurrence has little effect on actual clinical decisions. The editorial written by David E. Wazer, M.D., chief of the department of radiation oncology, is published in the current issue of the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-older-women-benefit-radiotherapy-breast.html Cancer Tue, 21 Aug 2012 11:49:46 EST news264768580 By identifying a key protein that tells certain breast cancer cells when and how to move, researchers at Michigan State University hope to better understand the process by which breast cancer spreads, or metastasizes. http://medicalxpress.com/news/2012-08-potential-cancer-roadblock.html Cancer Wed, 01 Aug 2012 14:20:01 EST news263048767 A simple and cost effective imaging device for breast tumor detection based on a flexible and wearable antenna system has been developed by researchers at the Indiana University – Purdue University Indianapolis. http://medicalxpress.com/news/2012-06-skin-contact-breast-tumor.html Cancer Fri, 29 Jun 2012 12:40:01 EST news260191763 Magnetic resonance imaging (MRI) provides an indication of a breast tumor's response to pre-surgical chemotherapy significantly earlier than possible through clinical examination, according to a new study published online in the journal Radiology. http://medicalxpress.com/news/2012-05-breast-mri-chemotherapy-effectiveness.html Cancer Wed, 23 May 2012 04:40:02 EST news256966083 Negative surgical margins should be attained for ductal carcinoma in situ (DCIS) patients after breast-conserving surgery (BCS) regardless of radiotherapy, and surgeons should attempt to reach wide negative margins in their first attempt within cosmetic restraint according to a study published March 22 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2012-03-margin-threshold-women-ductal-carcinoma.html Cancer Thu, 22 Mar 2012 16:00:01 EST news251637087 A new discovery published online in The FASEB Journal may lead to a new tool to help physicians assess breast cancer risk as well as diagnose the disease. In the report, researchers from Johns Hopkins University and the University of Maryland, explain how proteins, called "obscurins," once believed to only be in muscle cells, act as "tumor suppressor genes" in the breast. When their expression is lost, or their genes mutated in epithelial cells of the breast, cancer develops. It promises to tell physicians how breast cancer develops and/or how likely it is. http://medicalxpress.com/news/2012-03-obscurins-breast-tissue-physicians-cancer.html Cancer Wed, 21 Mar 2012 14:36:57 EST news251559405 (Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research describe how the protein phosphatase SHP2 promotes breast cancer with poor prognosis. As they report in the latest issue of Nature Medicine, SHP2 is necessary for the maintenance of the few tumor initiating cells (TICs) in a breast tumor. These cells are thought to sustain the growth of the tumor, promote metastasis and lead to relapses. http://medicalxpress.com/news/2012-03-breast-cancer-poor-prognosis.html Cancer Mon, 05 Mar 2012 08:56:18 EST news250160154 Cancers rarely are deadly unless they evolve the ability to grow beyond the tissues in which they first arise. Normally, cells -- even early-stage tumor cells -- are tethered to scaffolding that helps to restrain any destructive tendencies. But scientists from the University of Helsinki, Finland, and from UCSF have identified a cleaver-wielding protein that frees some tumor cells, allowing them to further misbehave. http://medicalxpress.com/news/2012-01-breast-cancer-triggered-protein.html Cancer Tue, 17 Jan 2012 10:24:05 EST news246018238 Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine. http://medicalxpress.com/news/2012-01-isg15-therapeutic-breast-cancer-cell.html Cancer Wed, 11 Jan 2012 16:26:47 EST news245521503 As a woman ages, her chances of being diagnosed with a lower-risk breast tumor increase, according to a novel study led by UCSF which found that for women over 50, a substantial number of cancers detected by mammograms have good prognoses. http://medicalxpress.com/news/2011-12-breast-cancers-lower-risk-widespread-mammograms.html Cancer Mon, 19 Dec 2011 12:34:16 EST news243520432 Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a protein discovered by his laboratory can inhibit the growth of breast cancer cells. The research will be published September 14, 2011 online in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2011-09-protein-suppress-breast-cancer-growth.html Cancer Wed, 14 Sep 2011 16:30:53 EST news235236613 New research published in Cancer Discovery, the newest journal of the American Association for Cancer Research, details a large-scale project in genetic profiling that has identified many of the weak points in breast tumor cells. http://medicalxpress.com/news/2011-08-genome-profiling-technique-weak-breast.html Cancer Wed, 03 Aug 2011 13:30:02 EST news231595901 A study revealed at SNM's 58th Annual Meeting is comparing the breast-tumor detection capabilities of two very different imaging technologies—breast-specific gamma imaging (BSGI), which provides functional images of breast physiology, and ultrasound—for women with complex breast imaging cases that require further evaluation. Many women who have dense breast tissue (radiodense breasts) are difficult to image using mammography, currently the gold standard of breast imaging. For women whose mammograms are not clear enough to determine whether cancer is present, support methods such as BSGI and ultrasound are used to answer any remaining diagnostic questions. http://medicalxpress.com/news/2011-06-gamma-imaging-superior-tumor-dense.html Cancer Mon, 06 Jun 2011 13:08:03 EST news226584475 Parsley is usually used as a decorative accent to a scrumptious meal, but don't set it aside just yet. In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing. The study was published recently in Cancer Prevention Research. http://medicalxpress.com/news/2011-05-parsley-celery-crucial-component-breast.html Cancer Mon, 09 May 2011 12:30:30 EST news224162997