http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. One of the most frustrating truths about cancer is that even when a treatment works, it often doesn't work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December 11, 2012, issue of Cancer Cell, a Cell Press publication, may have a way to stay one step ahead in the case of aggressive metastatic breast cancer. http://medicalxpress.com/news/2012-12-incurable-metastatic-breast-cancer-resistance.html Cancer Mon, 10 Dec 2012 12:00:05 EST news274359966 Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-12-obesity-overeating-menopause-breast-tumor.html Cancer Fri, 07 Dec 2012 11:10:08 EST news274098853 (HealthDay)—In women with breast cancer that has recurred but remains confined to in or near the breast, post-surgical chemotherapy appears to boost survival, new research shows. http://medicalxpress.com/news/2012-12-chemo-survival-breast-cancer.html Cancer Thu, 06 Dec 2012 16:20:01 EST news274030481 (Phys.org)—Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November 5 on the website of the Proceedings of the National Academy of Sciences, details how some tumors get the tools they need to metastasize. http://medicalxpress.com/news/2012-11-link-molecular-culprit-breast-cancer.html Cancer Sun, 25 Nov 2012 07:30:01 EST news273049193 Heart failure is a relatively common complication in older women with breast cancer, but the risk is even higher in those patients treated with adjuvant trastuzumab (Herceptin), Yale School of Medicine researchers report in the current issue of the Journal of the American College of Cardiology. http://medicalxpress.com/news/2012-11-heart-failure-older-breast-cancer.html Cardiology Wed, 14 Nov 2012 15:30:01 EST news272129356 When surgeons operate to remove a tumor, determining exactly where to cut can be tricky. Ideally, the entire tumor should be removed while leaving a continuous layer of healthy tissue, but current techniques for locating the tumors during surgery are imprecise. Now a multidisciplinary team from the University of California, San Diego, is developing an alternate means of precisely tagging breast cancer tumors for removal or targeted destruction. They will present the results of their investigations at the AVS 59th International Symposium and Exhibition, held Oct. 28 – Nov. 2 in Tampa, Fla. http://medicalxpress.com/news/2012-10-ultrasound-guided-surgery-breast-cancer-treatment.html Surgery Fri, 26 Oct 2012 16:10:02 EST news270486039 The spread of cancer cells from primary tumors to other parts of the body remains the leading cause of cancer-related deaths. The research group of Prof. Roderick Lim, Argovia Professor for Nanobiology of the Biozentrum and the Swiss Nanoscience Institute at the University of Basel, in collaboration with Dr. Cora-Ann Schönenberger from the Biozentrum, reveal in the journal "Nature Nanotechnology" how the unique nanomechanical properties of breast cancer cells are fundamental to the process of metastasis. http://medicalxpress.com/news/2012-10-cancer.html Cancer Tue, 23 Oct 2012 10:10:05 EST news270203885 (Medical Xpress)—A new study from Johns Hopkins researchers suggests that the lethal spread of breast cancer is as dependent on a tumor's protein-rich environment as on genetic changes inside tumor cells. http://medicalxpress.com/news/2012-10-breast-cancer-cells-enticed-tumorous.html Cancer Mon, 22 Oct 2012 13:07:00 EST news270129998 In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority of the tumor mass, form what is known as the "tumor microenvironment." This sea of noncancerous cells and the products they deposit appear to play key roles in tumor pathogenesis. http://medicalxpress.com/news/2012-10-discovery-reveals-important-clues-cancer.html Cancer Thu, 11 Oct 2012 13:44:38 EST news269181849 Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in both obesity and in breast cancer cells. http://medicalxpress.com/news/2012-10-endotrophin-links-obesity-breast-cancer.html Cancer Mon, 08 Oct 2012 12:00:09 EST news268911754 (Medical Xpress)—Magee-Womens Hospital of UPMC is the first and only hospital in western Pennsylvania to offer radioactive seed localization, an innovation allowing breast tumors that cannot be felt to be precisely located before surgery. http://medicalxpress.com/news/2012-09-radioactive-seeds-outcomes-breast-cancer.html Cancer Tue, 25 Sep 2012 08:04:16 EST news267778569 (Medical Xpress)—A study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has discovered how tamoxifen-resistant breast-cancer cells grow and proliferate. It also suggests that an experimental agent might offer a novel targeted therapy for tamoxifen-resistant breast cancer. http://medicalxpress.com/news/2012-08-therapy-tamoxifen-resistant-breast-cancer.html Cancer Thu, 30 Aug 2012 10:24:38 EST news265541068 The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-08-trpm7-protein-key-breast-cancer.html Cancer Tue, 07 Aug 2012 13:35:02 EST news263565284 (Medical Xpress) -- Chao Zhou believes his work with combining imaging technologies has the potential to improve surgeries that remove malignant breast tumors. http://medicalxpress.com/news/2012-07-accurate-noninvasive-cancerous-tumors.html Cancer Tue, 10 Jul 2012 07:10:01 EST news261122117 Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. http://medicalxpress.com/news/2012-07-protein-resistance-widely-anti-estrogen-drugs.html Cancer Mon, 02 Jul 2012 03:59:03 EST news260420323 Certain short strands of RNA, known as microRNAs (miRNAs), have been linked to the progression and metastasis of breast cancer and may provide information about prognosis. However, studies of miRNA expression profiles often report conflicting findings. While the potential for using miRNAs in breast cancer diagnosis is promising, scientists report in a new study published online today in The Journal of Molecular Diagnostics that differences in the amount and types of miRNA within breast tumors can be misleading. http://medicalxpress.com/news/2012-06-sample-multiple-tumor-zones-breast.html Cancer Fri, 15 Jun 2012 00:00:02 EST news258913629 A study led by Vanderbilt-Ingram Cancer Center (VICC) investigators has identified a gene expression pattern that may explain why chemotherapy prior to surgery isn't effective against some tumors and suggests new therapy options for patients with specific subtypes of breast cancer. http://medicalxpress.com/news/2012-06-genes-linked-resistance-breast-cancer.html Cancer Mon, 11 Jun 2012 15:21:33 EST news258646852 Decoding the DNA of patients with advanced breast cancer has allowed scientists to identify distinct cancer "signatures" that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment. http://medicalxpress.com/news/2012-06-scientists-decode-dna-breast-tumor.html Genetics Sun, 10 Jun 2012 13:00:06 EST news258548280 Researchers and doctors at the North Shore-LIJ Health System and the Feinstein Institute for Medical Research have discovered a potential explanation for why breast cancer is not experienced the same way with African American and Caucasian patients. This data will be presented at the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting to be held from Friday through Tuesday (June 1-5) in Chicago, IL. http://medicalxpress.com/news/2012-06-dna-marker-differences-breast-cancer.html Cancer Sat, 02 Jun 2012 13:07:08 EST news257861219 Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells. http://medicalxpress.com/news/2012-05-breast-stem-cell-receptor-teamwork-required.html Cancer Wed, 30 May 2012 13:40:01 EST news257602172 (AP) -- Men rarely get breast cancer, but those who do often don't survive as long as women, largely because they don't even realize they can get it and are slow to recognize the warning signs, researchers say. http://medicalxpress.com/news/2012-05-breast-cancer-rare-men-fare.html Cancer Fri, 04 May 2012 16:10:02 EST news255365833 Breast cancer patients whose tumors express high levels of genes related to immune response are more likely to have their tumor completely eradicated by pre-operative chemotherapy compared to patients with low expression of these genes, Belgian researchers report at the 4th IMPAKT Breast Cancer Conference in Brussels, Belgium. http://medicalxpress.com/news/2012-05-immune-response-genes-affecting-breast-tumor.html Cancer Thu, 03 May 2012 11:50:03 EST news255260980 (Medical Xpress) -- Could engineered human stem cells hold the key to cancer survival? Scientists at the Institute of Bioengineering and Nanotechnology (IBN), the world's first bioengineering and nanotechnology research institute, have discovered that neural stem cells possess the innate ability to target tumor cells outside the central nervous system. This finding, which was demonstrated successfully on breast cancer cells, was recently published in leading peer reviewed journal, Stem Cells. http://medicalxpress.com/news/2012-04-discovery-breast-cancer-therapy.html Cancer Fri, 20 Apr 2012 07:00:01 EST news254123095 (Medical Xpress) -- Researchers in the Program in Cellular and Molecular Medicine at Boston Children's Hospital and the Immune Disease Institute (PCMM/IDI) have developed a molecular delivery platform that overcomes one of the biggest obstacles to using RNA-based gene silencing technologies to treat cancer: Making sure the treatment gets to the right place and stays there. http://medicalxpress.com/news/2012-04-packaging-therapeutic-rnas-treatment-breast.html Cancer Thu, 19 Apr 2012 07:10:01 EST news254037452 It should be possible to significantly improve the response of common cancers to existing "classical" chemotherapy drugs, say scientists at Cold Spring Harbor Laboratory (CSHL), by introducing agents that alter the interaction of cancer cells with their immediate surroundings, called the tumor microenvironment. http://medicalxpress.com/news/2012-04-imaging-response-cancer-drugs-boosted.html Cancer Mon, 16 Apr 2012 12:59:03 EST news253799935 Mayo Clinic researchers have discovered a new class of molecular mutation in various forms of breast cancer, a finding that may shed new light on development and growth of different types of breast tumors. Called fusion transcripts, the mutated forms of RNA may also provide a way to identify tumor subtypes and offer new strategies to treat them, investigators say. http://medicalxpress.com/news/2012-04-breast-cancer-mutation.html Cancer Mon, 16 Apr 2012 03:44:08 EST news253765667 A new class of agents known as c-Src inhibitors is being tested in a number of different ways to treat breast cancer, but researchers at Georgetown Lombardi Comprehensive Cancer Center caution that they should not be used in combination with estrogen to treat endocrine resistant breast cancer. http://medicalxpress.com/news/2012-04-specific-agents-worse-endocrine-resistant.html Cancer Mon, 02 Apr 2012 15:50:01 EST news252586174 Studies exploring the relationship between soy consumption and breast cancer have been mixed, but new research introduces a new thought: Could women with breast cancer who began eating soy as an adult develop a tumor more resistant to treatment? http://medicalxpress.com/news/2012-04-links-breast-cancer-resistance-soy.html Cancer Mon, 02 Apr 2012 14:00:01 EST news252584540 Lymph nodes help to fight off infections by producing immune cells and filtering foreign materials from the body, such as bacteria or cancer cells. Thus, one of the first places that cancer cells are found when they leave the primary tumor is in the lymph nodes. The spread of cancer cells to the lymph nodes, lymphatic metastasis, is known to indicate a poor prognosis in many types of cancers; how tumor cells reach the lymph nodes, however, is not well understood. http://medicalxpress.com/news/2012-04-pathway-linked-breast-cancer-metastasis.html Cancer Mon, 02 Apr 2012 12:00:04 EST news252584321 Putting the brakes on an abundant growth-promoting protein causes breast tumors to regress, according to a study published on March 19th in the Journal of Experimental Medicine. http://medicalxpress.com/news/2012-03-backbone-triple-negative-breast-cancers.html Cancer Mon, 19 Mar 2012 12:00:06 EST news251374976