http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. The drug bevacizumab, also known by the trade name Avastin, shrinks tumors briefly in patients with an aggressive brain cancer known as glioblastoma multiforme, but then they often grow again and spread throughout the brain for reasons no one previously has understood. Now, Mayo Clinic researchers have found out why this happens. They have also discovered that pairing Avastin with another cancer drug, dasatinib, can stop that lethal spread. Dasatinib is approved for use in several blood cancers. http://medicalxpress.com/news/2013-02-combo-avastin-drug-brain-cancer.html Cancer Thu, 14 Feb 2013 17:20:01 EST news280083387 Researchers employed an extensive analysis of genomic information to identify a new, high-risk cohort of ovarian cancer patients, characterize their tumors, find a potential treatment and test it in mouse models of the disease. http://medicalxpress.com/news/2013-02-deep-genomic-analysis-micro-rna.html Cancer Mon, 11 Feb 2013 15:37:36 EST news279819376 Early laboratory tests are the first to successfully use an experimental molecular therapy to block a hard-to-target part of a protein complex linked to several types of invasive cancer. http://medicalxpress.com/news/2013-02-molecular-inhibitors-successfully-difficult-cancer.html Cancer Tue, 05 Feb 2013 09:45:59 EST news279279861 Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters. http://medicalxpress.com/news/2013-02-epidermal-growth-factor-aids-stem.html Medical research Sun, 03 Feb 2013 13:00:09 EST news279115273 Blood vessels that supply oxygen and nutrients to tumors can also deliver something else - a signal that strengthens nearby cancer cells, making them more resistant to chemotherapy, more likely to spread to other organs and more lethal, scientists at The University of Texas MD Anderson Cancer Center report online in Cancer Cell. http://medicalxpress.com/news/2013-02-blood-vessel-cells-coax-colorectal.html Cancer Fri, 01 Feb 2013 10:31:19 EST news278937053 Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that deregulation of this pathway does not necessarily signify that the tumor is dependent on it for survival and progression. http://medicalxpress.com/news/2013-01-common-genetic-neck-cancers-key.html Cancer Tue, 29 Jan 2013 13:00:01 EST news278676552 Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins – known as Src – leads to ovarian cancer progression when exposed to stress hormones. The researchers report in the current issue of Nature Communications that beta blocker drugs mitigate this effect and reduce cancer deaths by an average of 17 percent. http://medicalxpress.com/news/2013-01-preclinical-master-proto-oncogene-ovarian-cancer.html Cancer Tue, 29 Jan 2013 11:00:04 EST news278676493 The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, as opposed to ones based on enzymes. Now, researchers have identified a class of p53 target genes and regulatory molecules that represent more promising therapeutic candidates. http://medicalxpress.com/news/2013-01-cancer-suppressor-gene-links-metabolism.html Cancer Sun, 13 Jan 2013 13:00:20 EST news277297188 (Medical Xpress)—A nutritional supplement available over-the-counter may offer protection from Alzheimer's disease, a study by the University of Virginia and Northwestern University suggests. http://medicalxpress.com/news/2013-01-nutritional-supplement-alzheimer.html Alzheimer's disease & dementia Thu, 10 Jan 2013 06:12:46 EST news277020757 Researchers in California and Switzerland have discovered that melanomas that develop resistance to the anti-cancer drug vemurafenib (marketed as Zelboraf), also develop addiction to the drug, an observation that may have important implications for the lives of patients with late-stage disease. http://medicalxpress.com/news/2013-01-drug-resistant-melanoma-tumors-therapy.html Cancer Wed, 09 Jan 2013 13:00:01 EST news276953856 Researchers at the Kimmel Cancer Center at Jefferson (KCC) have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers. http://medicalxpress.com/news/2012-12-game-diagnostic-prognostic-prostate-cancer.html Cancer Thu, 20 Dec 2012 12:15:38 EST news275228128 Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation chemoprevention therapy. http://medicalxpress.com/news/2012-12-prostate-cancer-androgen-deprivation-effects.html Cancer Thu, 20 Dec 2012 10:39:48 EST news275222382 (Medical Xpress)—A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels—a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress. http://medicalxpress.com/news/2012-12-unravels-biological-pathway-leakiness-blood.html Medical research Mon, 17 Dec 2012 10:57:35 EST news274964245 Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1). http://medicalxpress.com/news/2012-12-molecular-therapy-untreatable-nf1-tumors.html Cancer Mon, 10 Dec 2012 12:00:15 EST news274359400 One of the most frustrating truths about cancer is that even when a treatment works, it often doesn't work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December 11, 2012, issue of Cancer Cell, a Cell Press publication, may have a way to stay one step ahead in the case of aggressive metastatic breast cancer. http://medicalxpress.com/news/2012-12-incurable-metastatic-breast-cancer-resistance.html Cancer Mon, 10 Dec 2012 12:00:05 EST news274359966 Inflammatory breast cancer (IBC) is a very rare and aggressive disease that progresses rapidly and is associated with a very low survival rate. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3D environment. Researchers at Fox Chase Cancer Center have developed a novel, 3D culture system that mimics the environment surrounding these cancer cells. This model could be used to test new anticancer drugs capable of inhibiting the spread of IBC tumors. http://medicalxpress.com/news/2012-12-d-culture-inflammatory-breast-cancer.html Cancer Sun, 09 Dec 2012 02:51:18 EST news274243825 (Medical Xpress)—The work of a team of Wake Forest researchers developing a novel drug for prostate cancer treatment is featured on the cover of the Nov. 26 issue of the Journal of Medicinal Chemistry. http://medicalxpress.com/news/2012-11-treatment-prostate-cancer.html Cancer Thu, 29 Nov 2012 07:42:07 EST news273397310 One of the most outstanding and unresolved questions in cancer biology is the identification of cells at the origin of cancer and the understanding of the molecular changes that occur in tumor initiating cells from the first oncogenic mutation to the development of invasive cancer. Basal cell carcinoma (BCC) is the most frequent cancer in human with more than million of new patients diagnosed each year with BCCs. Recently, the group of Pr. Cédric Blanpain uncovered the cells at the origin of BCC (Youssef et al, Nature Cell Biology, 2010). http://medicalxpress.com/news/2012-11-uncover-molecular-mechanisms-basal-cell.html Cancer Mon, 26 Nov 2012 09:40:01 EST news273144152 UT Southwestern Medical Center scientists led by Dr. Sean Morrison, director of the Children's Medical Center Research Institute at UT Southwestern, have developed an innovative model for predicting the progression of skin cancer in patients. http://medicalxpress.com/news/2012-11-human-melanoma-cells-mice-clinical.html Cancer Wed, 07 Nov 2012 14:00:01 EST news271508229 Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson's Kimmel Cancer Center researchers. http://medicalxpress.com/news/2012-10-stat5-outcomes-prostate-cancer-patients.html Cancer Tue, 16 Oct 2012 12:54:27 EST news269610859 A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson's Kimmel Cancer Center researchers suggests. http://medicalxpress.com/news/2012-10-advanced-prostate-cancer-parp-inhibitors.html Cancer Tue, 09 Oct 2012 15:14:17 EST news269014450 The hormone prolactin is produced by the pituitary gland in the brain and then travels via the bloodstream to cells throughout the body, where it exerts multiple reproductive and metabolic effects, most notably on the breast where it is the master regulator of lactation. In recent years researchers have found that prolactin is also produced by some tissues outside the brain, however little is known about the functions of extra-pituitary prolactin or how its production is regulated in these tissues. http://medicalxpress.com/news/2012-10-insights-pituitary-hormone-brain-implications.html Genetics Mon, 01 Oct 2012 03:29:39 EST news268280802 Breast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research. http://medicalxpress.com/news/2012-07-breast-cancer-patients-lack-rb.html Cancer Thu, 26 Jul 2012 16:15:57 EST news262538147 The HIV drugs known as CCR5 antagonists may also help prevent aggressive breast cancers from metastasizing, researchers from the Kimmel Cancer Center at Jefferson suggest in a preclinical study published in a recent issue of Cancer Research. http://medicalxpress.com/news/2012-06-hiv-drug-metastatic-breast-cancer.html Cancer Wed, 06 Jun 2012 15:27:01 EST news258215206 A single gene that promotes initial development of the most common form of lung cancer and its lethal metastases has been identified by researchers at Mayo Clinic in Florida. Their study suggests other forms of cancer may also be driven by this gene, matrix metalloproteinase-10 (MMP-10). http://medicalxpress.com/news/2012-04-gene-critical-lung-cancer.html Cancer Tue, 24 Apr 2012 17:00:07 EST news254505257 Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments. http://medicalxpress.com/news/2012-04-scientists-breast-cancer-genes-rewrite.html Cancer Wed, 18 Apr 2012 13:00:15 EST news253972596 Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles - called iPhage - to organelles inside the cell. http://medicalxpress.com/news/2012-04-scientists-tailor-cell-surface-organelle.html Medical research Tue, 17 Apr 2012 16:17:25 EST news253898239 Anurag Singh, PhD, assistant professor in the Department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine has been invited to present his recent work on targeted therapeutics for colon cancer at the American Association of Cancer Research Annual Meeting in Chicago, IL. Singh's seminar, scheduled for Tuesday April 3rd, will be featured in the "Late-Breaking Abstracts Mini-Symposium". This highlights recent and provocative groundbreaking research in cancer biology. http://medicalxpress.com/news/2012-04-therapeutics-colon-cancer-aacr.html Cancer Wed, 04 Apr 2012 01:48:21 EST news252722892 Researchers at King's College London and Hiroshima University, Japan, have identified a specific gene linked to throat cancer following a genetic study of a family with 10 members who have developed the condition. http://medicalxpress.com/news/2012-03-throat-cancer-gene-uncovered.html Cancer Thu, 08 Mar 2012 12:03:29 EST news250430583 The infamous BRCA genes do not act alone in causing cancer; there is a molecular syndicate at work preventing the way cells normally repair breaks in DNA that is at the root of breast cancer. But finding all of the BRCA molecular collaborators has been elusive. http://medicalxpress.com/news/2012-02-member-breast-cancer-gene-network.html Cancer Wed, 22 Feb 2012 14:00:01 EST news249136869