http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. (Medical Xpress)—Researchers at the University of Illinois have identified biomarkers that can be used to determine ovarian cancer survival and recurrence, and have shown how these biomarkers interact with each other to affect these outcomes. http://medicalxpress.com/news/2013-04-team-markers-ovarian-cancer-survival.html Cancer Tue, 30 Apr 2013 05:41:37 EST news286519289 Tumourigenesis is driven by genetic alterations and by changes in the epigenome, for instance by the addition of methyl groups to cytosine bases in the DNA. A deeper understanding of the interaction between the genetic and epigenetic mechanisms is critical for the selection of tumour biomarkers and for the future development of therapies. Human tumour specimens and cell lines however contain a plethora of genetic and epigenetic changes, which complicate data analysis. In contrast, certain mouse tumour models contain only a single genetic mutation and allow the analysis of nascent tumours. Scientists of the Max Planck Institute for Molecular Genetics in Berlin have now discovered a recurring pattern of more than 13,000 epigenetic alterations in young tumours of the mouse. This genome-wide pattern was found to be partly conserved in human colon carcinoma, and may therefor facilitate the identification of novel clinical colon cancer biomarkers for early detection. http://medicalxpress.com/news/2013-02-colon-cancer-epigenetic-pattern-mice.html Genetics Thu, 07 Feb 2013 17:00:03 EST news279472308 As many as 50 percent of all human protein-coding genes are regulated by microRNA (miRNA) molecules. While some miRNAs impact onset and progression of cancer, others can actually suppress the development of malignant tumors and are useful in cancer therapy. They can also serve as potential biomarkers for early cancer detection. In a new issue of Cancer Biomarkers, investigators report on non-coding miRNAs as appealing biomarkers for malignancy. http://medicalxpress.com/news/2012-12-micrornas-opportunities-cancer-therapy-diagnosis.html Cancer Wed, 19 Dec 2012 17:54:23 EST news275162056 (Medical Xpress)—University of Leicester scientists will present groundbreaking new evidence about how a chemical found in red wine can help prevent cancer on Wednesday, December 5. http://medicalxpress.com/news/2012-12-evidence-compound-red-wine-cancer.html Cancer Tue, 04 Dec 2012 19:00:05 EST news273863979 (Medical Xpress)—Using something called "inertial microfluidics," University of Cincinnati researchers are able to continuously and selectively collect rare cells, such as circulating tumor cells, based on their size vs. other biomarkers. This could reduce analysis time and increase selectivity while reducing reliance on antibody-based testing in clinical tests. http://medicalxpress.com/news/2012-10-options-ease-accuracy-rare-cells.html Cancer Fri, 26 Oct 2012 12:20:04 EST news270470483 (Medical Xpress) -- Researchers from ETH Zurich have developed a procedure to test the clinical benefits of cancer biomarkers. The method could radically shorten the path from the lab to their application. http://medicalxpress.com/news/2012-07-cancer-biomarkers-re-evaluated.html Cancer Thu, 19 Jul 2012 09:25:41 EST news261908719 The strategy used by Google to decide which pages are relevant for a search query can also be used to determine which proteins in a patient's cancer are relevant for the disease progression. Researchers from Dresden University of Technology, Germany, have used a modified version of Google's PageRank algorithm to rank about 20,000 proteins by their genetic relevance to the progression of pancreatic cancer. In their study, published in PLoS Computational Biology, they found seven proteins that can help to assess how aggressive a patient's tumor is and guide the clinician to decide if that patient should receive chemotherapy or not. http://medicalxpress.com/news/2012-05-google-cancer-algorithm-biomarkers.html Cancer Thu, 17 May 2012 17:05:36 EST news256493125 Physical activity is associated with reduced breast and colon cancer mortality, but there is insufficient evidence on the association for other cancer types, according to a study published May 8 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2012-05-physical-linked-mortality-breast-colon.html Cancer Tue, 08 May 2012 16:00:15 EST news255696645 A team of researchers led by A. K. Rajasekaran, PhD, Director of the Nemours Center for Childhood Cancer Research, has shown that a key protein involved in cell function and regulation is stopped by a substance present in cigarette smoke. Their work is published online in the American Journal of Physiology - Lung Cell and Molecular Physiology. http://medicalxpress.com/news/2012-03-uncover-evidence-cancer-causing-agent-gaseous.html Medical research Wed, 21 Mar 2012 12:05:54 EST news251550346 A new Oxford University spin-out firm, Oxford Cancer Biomarkers Limited, is to develop technology to ensure that only patients who are likely to benefit from anti-cancer drugs will receive them and that the best treatment for each person can be quickly identified. http://medicalxpress.com/news/2012-01-spin-out-cancer-treatment.html Cancer Wed, 25 Jan 2012 11:33:57 EST news246713631 Tumors can grow for 10 years or longer before currently available blood tests will detect them, a new mathematical model developed by Stanford University School of Medicine scientists indicates. The analysis, which was restricted to ovarian tumors but is broadly applicable across all solid tumor types, will be published online Nov. 16 in Science Translational Medicine. http://medicalxpress.com/news/2011-11-guidelines-earlier-cancer.html Cancer Wed, 16 Nov 2011 14:00:04 EST news240665376 Using a new approach to developing biomarkers for the very early detection of ovarian cancer, researchers at Rush University Medical Center have identified a molecule in the bloodstream of infertile women that could one day be used to screen for those at high risk for the disease — or even those with early-stage ovarian cancer. http://medicalxpress.com/news/2011-08-antibody-ovarian-cancer-earliest-stages.html Cancer Tue, 16 Aug 2011 13:53:16 EST news232721583 We've heard it repeatedly: early detection is key to surviving breast cancer. But even with recent advances in mammography, finding indications of breast cancer before it can metastasize remains a problem. Scientists at Pacific Northwest National Laboratory and Duke University Medical Center have increased the ability to determine if a positive result on a breast cancer screen is true or false. http://medicalxpress.com/news/2011-06-high-false-positive-mammograms.html Cancer Mon, 13 Jun 2011 10:42:46 EST news227180551 A new, promising marker for diagnosing prostate cancer has been discovered by Swedish researchers with the aid of a unique method developed at the Department of Immunology, Genetics and Pathology. The study, being published this week in the journal Proceedings of the National Academy of Sciences, PNAS, can lead to more reliable diagnoses and fewer unnecessary operations. http://medicalxpress.com/news/2011-05-marker-reliable-prostate-cancer.html Cancer Mon, 09 May 2011 15:00:38 EST news224161418 A study of more than 100,000 men and women over 14 years finds nonsmokers who followed recommendations for cancer prevention had a lower risk of death from cancer, cardiovascular disease, and all-causes. The study appears early online in Cancer Biomarkers, Epidemiology, and Prevention, and was led by American Cancer Society epidemiologists. http://medicalxpress.com/news/2011-04-cancer-guidelines-lowers-death-heart.html Cancer Thu, 14 Apr 2011 10:40:09 EST news221996383