http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point. http://medicalxpress.com/news/2013-06-scientists-egfr-crucial-message-cancer-promoting.html Cancer Tue, 18 Jun 2013 16:20:19 EST news290791210 A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study. http://medicalxpress.com/news/2013-06-osteoporosis-drug-growth-breast-cancer.html Cancer Sat, 15 Jun 2013 14:00:01 EST news290443863 A team of UT Arlington researchers has identified two ruthenium-based complexes they believe could pave the way for treatments that control cancer cell growth more effectively and are less toxic for patients than current chemotherapies. http://medicalxpress.com/news/2013-05-ruthenium-complexes-cancer-cells-typical.html Cancer Tue, 28 May 2013 15:39:31 EST news288974364 In a landmark cancer study published online in Nature, researchers at NYU School of Medicine have unraveled a longstanding mystery about how pancreatic tumor cells feed themselves, opening up new therapeutic possibilities for a notoriously lethal disease with few treatment options. Pancreatic cancer kills nearly 38,000 Americans annually, making it a leading cause of cancer death. The life expectancy for most people diagnosed with it is less than a year. http://medicalxpress.com/news/2013-05-breakthrough-pancreatic-cancer-cells-ingest.html Cancer Mon, 13 May 2013 16:47:33 EST news287682443 UT Southwestern Medical Center researchers report that a pathogen annually blamed for an estimated 90 million cases of food-borne illness defeats a host's immune response by using a fat-snipping enzyme to cut off cellular communication. http://medicalxpress.com/news/2013-04-scissor-like-enzyme-treatment-infectious-disease.html Medical research Thu, 04 Apr 2013 10:52:48 EST news284291553 (Medical Xpress)—Bioengineering researchers at University of California, Santa Barbara have found that changing the shape of chemotherapy drug nanoparticles from spherical to rod-shaped made them up to 10,000 times more effective at specifically targeting and delivering anti-cancer drugs to breast cancer cells. http://medicalxpress.com/news/2013-02-chemotherapy-drugs-cancer-cells.html Cancer Wed, 27 Feb 2013 14:56:32 EST news281199376 (Medical Xpress)—A new drug combination shows promise in reducing the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included preclinical and clinical analyses, were published in Clinical Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2013-02-drug-combination-neck-cancer-high-risk.html Cancer Tue, 19 Feb 2013 14:10:01 EST news280504253 Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; AMPK is turned on when it senses changes in energy levels, and helps to change metabolism when energy levels are low, such as during exercise or when fasting. The researchers found that AMPK also regulates cancer cell metabolism and can restrict cancer cell growth. http://medicalxpress.com/news/2012-12-cellular-fuel-gauge-key-restricting.html Cancer Thu, 27 Dec 2012 13:02:43 EST news275835756 A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. http://medicalxpress.com/news/2012-12-uncovers-mechanism-brca1-suppress-tumors.html Cancer Mon, 17 Dec 2012 06:00:01 EST news274903771 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma and the seventh most frequently diagnosed cancer. The most chemotherapy resistant form of DLBCL, called activated B-cell – DLBCL (ABC-DLBCL), remains a major therapeutic challenge. An international research team, led by two laboratories from Weill Cornell Medical College, has developed a new experimental drug therapy to target this aggressive form of lymphoma. http://medicalxpress.com/news/2012-12-drug-therapy-aggressive-non-hodgkin-lymphoma.html Cancer Mon, 10 Dec 2012 15:46:52 EST news274376793 (Medical Xpress)—A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease. http://medicalxpress.com/news/2012-11-clues-tamoxifen-resistant-breast-cancer.html Cancer Fri, 02 Nov 2012 10:44:17 EST news271071834 Researchers have published the first highly detailed description of how neurotensin, a neuropeptide hormone which modulates nerve cell activity in the brain, interacts with its receptor. Their results suggest that neuropeptide hormones use a novel binding mechanism to activate a class of receptors called G-protein coupled receptors (GPCRs). http://medicalxpress.com/news/2012-10-scientists-view-brain-protein-results.html Medical research Wed, 10 Oct 2012 13:00:12 EST news269092277 A molecule that targets the cell's machinery for breaking down unneeded proteins can kill multiple myeloma cancer cells resistant to the frontline drug Velcade, researchers at Dana-Farber Cancer Institute have found. http://medicalxpress.com/news/2012-09-molecule-effectiveness-drug-resistant-myeloma.html Cancer Mon, 10 Sep 2012 12:00:04 EST news266491091 Through novel experiments involving small nematode worms, scientists from Wyoming have discovered several genes that may be potential targets for drug development in the ongoing war against cancer. Specifically, researchers hypothesize that inhibiting these genes could reverse certain key traits associated with cancer cells. This discovery is published in the August 2012 issue of the Genetics Society of America's journal GENETICS. http://medicalxpress.com/news/2012-08-scientists-worms-unearth-cancer-drug.html Cancer Thu, 09 Aug 2012 11:28:05 EST news263730476 (Medical Xpress) -- Yale Cancer Center geneticists, biochemists, and structural biologists have painted the most comprehensive picture yet of the molecular landscape of melanoma, a highly aggressive and often deadly skin cancer. The study appears in the July 29 advance online publication of Nature Genetics. http://medicalxpress.com/news/2012-07-scientists-uncover-gene-variation-linked.html Genetics Sun, 29 Jul 2012 17:06:47 EST news262800400 A study conducted at Boston University School of Medicine (BUSM) demonstrates an effective combination therapy for breast cancer cells in vitro. The findings, published in the July 2012 issue of Anticancer Research, raise the possibility of using this type of combination therapy for different forms of breast cancer, including those that develop resistance to chemotherapy and other treatments. http://medicalxpress.com/news/2012-07-vitro-potential-combination-therapy-breast.html Cancer Mon, 02 Jul 2012 12:07:10 EST news260449621 It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. http://medicalxpress.com/news/2012-06-aging-cells-fuels-tumor-growth.html Cancer Thu, 14 Jun 2012 14:59:36 EST news258904683 A molecule thought to limit cell proliferation also helps cancer cells survive during initial tumor formation and when the wayward cells spread to other organs in the body, researchers at the University of Illinois at Chicago College of Medicine have found. http://medicalxpress.com/news/2012-06-key-enzyme-roles-friend-foe.html Medical research Thu, 14 Jun 2012 08:55:53 EST news258882913 (HealthDay) -- Perjeta (pertuzumab) has been approved by the U.S. Food and Drug Administration to treat people with HER2-positive late-stage breast cancer, the agency said in a news release. http://medicalxpress.com/news/2012-06-perjeta-advanced-breast-cancer.html Cancer Mon, 11 Jun 2012 14:00:06 EST news258640641 A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive Cancer Center researchers conducting the study in cancer patients whose tumors have resisted multiple treatments say the combination demonstrates "promising evidence" of disease control and should be studied in a phase II trial. Their clinical findings and additional data from the study will be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, June 1 through 5, 2012. http://medicalxpress.com/news/2012-05-phase-temsirolimus-capecitabine-safe-positive.html Cancer Wed, 16 May 2012 18:00:03 EST news256406984 Apigenin, a natural substance found in grocery store produce aisles, shows promise as a non-toxic treatment for an aggressive form of human breast cancer, following a new study at the University of Missouri. MU researchers found apigenin shrank a type of breast cancer tumor that is stimulated by progestin, a synthetic hormone given to women to ease symptoms related to menopause. http://medicalxpress.com/news/2012-05-breast-cancer-effectively-chemical-celery.html Cancer Wed, 16 May 2012 09:20:14 EST news256378808 A Simon Fraser University researcher is among four scientists who argue that cholesterol may slow or stop cancer cell growth. They describe how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins, a paper published in the latest issue of the Journal of Biological Chemistry. http://medicalxpress.com/news/2012-04-cancer-fighting-goodness-cholesterol.html Cancer Thu, 19 Apr 2012 16:20:02 EST news254070769 Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson's Kimmel Cancer Center researchers. http://medicalxpress.com/news/2012-04-good-cholesterol-receptor-breast-cancer.html Cancer Tue, 03 Apr 2012 15:49:20 EST news252686774 The dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, a Mayo Clinic study has found. The supplement, a fatty acid also known as GLA, worked particularly well when combined with the chemotherapy drug gemcitabine, the researchers say. The findings were presented today by Mayo Clinic pathologist Ruth Lupu, Ph.D., at the American Association for Cancer Research (AACR) Annual Meeting 2012. http://medicalxpress.com/news/2012-04-nutritional-supplement-pancreatic-cancer-cells.html Cancer Tue, 03 Apr 2012 09:47:47 EST news252665248 Mitochondria, tiny structures within each cell that regulate metabolism and energy use, may be a promising new target for cancer therapy, according to a new study. Manipulation of two biochemical signals that regulate the numbers of mitochondria in cells could shrink human lung cancers transplanted into mice, a team of Chicago researchers report in the journal FASEB. http://medicalxpress.com/news/2012-02-energy-network-cells-cancer-therapy.html Cancer Tue, 21 Feb 2012 11:00:01 EST news249043340 Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. http://medicalxpress.com/news/2012-02-prostate-cancer-drug.html Cancer Mon, 06 Feb 2012 15:00:16 EST news247755688 Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-02-soy-isoflavone-supplements-breast-cancer.html Cancer Fri, 03 Feb 2012 11:15:00 EST news247490093 Lithocholic acid (LCA), naturally produced in the liver during digestion, has been seriously underestimated. A study published in the journal Oncotarget shows that LCA can kill several types of cancer cells, such as those found in some brain tumors and breast cancer. http://medicalxpress.com/news/2012-01-cancer-killing-compound-healthy-cells.html Cancer Wed, 04 Jan 2012 12:22:53 EST news244902162 Scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. http://medicalxpress.com/news/2011-12-scientists-cancer.html Cancer Mon, 12 Dec 2011 12:48:14 EST news242916460 Precisely quantifying the amount of three different HER growth proteins, along with several other proteins believed linked to breast cancer, did not predict a patient's outcome after treatment for HER2-Positive Breast Cancer with Herceptin, say Mayo Clinic researchers. HER2-positive breast cancer gets its name from a protein called human epidermal growth factor receptor 2 that promotes cancer cell growth. http://medicalxpress.com/news/2011-12-proteins-outcome-herceptin-treatment-her2-positive.html Cancer Fri, 09 Dec 2011 03:00:01 EST news242620870