http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology. http://medicalxpress.com/news/2012-10-lactation-protein-suppresses-tumors-metastasis.html Cancer Wed, 24 Oct 2012 09:00:01 EST news270284902 (Medical Xpress)—Researchers at Moffitt Cancer Center have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. This knowledge, said the researchers, could pave the way for a therapeutic target for ovarian cancer. http://medicalxpress.com/news/2012-09-key-ovarian-cancer-stem-cells.html Cancer Thu, 27 Sep 2012 04:45:33 EST news267939812 A receptor protein suppresses local invasion and metastasis of breast cancer cells, the most lethal aspect of the disease, according to a research team headed by scientists from The University of Texas MD Anderson Cancer Center. http://medicalxpress.com/news/2012-09-lifr-protein-suppresses-breast-cancer.html Cancer Tue, 25 Sep 2012 09:35:21 EST news267784508 The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering studies have found that breast cancer cells grown on a 3-D gel have enhanced cell replication and decreased organization as rigidity increases. These signals are probably coordinated by surface proteins that communicate with connective tissue, to regulate cell replication, death, and movement. However, very little is known about how stiffness or other physical characteristics of tissues contributes to cancer behavior in living animals. http://medicalxpress.com/news/2012-09-tension-gut-muscles-cell-invasion.html Cancer Fri, 07 Sep 2012 17:01:13 EST news266256043 A synthetic, anti-inflammatory and anti-allergic family of drugs to combat a variety of illnesses while avoiding detrimental side effects has been developed by a Hebrew University of Jerusalem researcher. http://medicalxpress.com/news/2012-09-multi-functional-anti-inflammatoryanti-allergic.html Inflammatory disorders Thu, 06 Sep 2012 11:20:33 EST news266149213 Cancer metastasis, the escape and spread of primary tumor cells, is a common cause of cancer-related deaths. But metastasis remains poorly understood. Studies indicate that when a primary tumor breaks through a blood vessel wall, blood's "stickiness" tears off tumor cells the way a piece of tape tears wrapping paper. http://medicalxpress.com/news/2012-08-metastasis.html Cancer Fri, 24 Aug 2012 10:40:01 EST news265021775 A lysophosphatidic acid receptor 1 (LPAR1) inhibitor, known as Debio-0719, suppresses the development of metastases in mice by inducing cancer cell dormancy, according to a study published August 21 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2012-08-lpa1-inhibition-metastatic-dormancy-mouse.html Cancer Tue, 21 Aug 2012 16:00:07 EST news264782231 The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-08-trpm7-protein-key-breast-cancer.html Cancer Tue, 07 Aug 2012 13:35:02 EST news263565284 A team of researchers led by Dr. Goutham Narla at Case Western Reserve University School of Medicine in collaboration with scientists at Mount Sinai School of Medicine in New York, have discovered a previously unrecognized signaling network disrupted in lung cancer that can be turned back on by a novel combination of two previously approved FDA drugs. The drug combination targets a pathway to treat advanced/late stage lung cancer. The work highlights how understanding the basic mechanisms regulating cancer development and progression can lead to new uses for existing FDA approved drugs in the treatment of cancer. http://medicalxpress.com/news/2012-06-combination-previously-fda-drugs-lung.html Cancer Fri, 01 Jun 2012 13:02:03 EST news257774514 Cancer researchers have known for well over a century that different tumor types spread only to specific, preferred organs. But no one has been able to determine the mechanisms of organ specific metastasis, the so-called "soil and seed" theory of 1889. New details that could help shed light on this hypothesis have been provided by a team of researchers from Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, and their collaborators, proposing a new mechanism controlling cancer metastasis that offers fresh diagnostic and treatment potential. http://medicalxpress.com/news/2012-05-cancerous-tumors-pro-metastatic-secreted-vesicles.html Cancer Tue, 29 May 2012 12:35:50 EST news257513741 Researchers from VTT Technical Research Centre of Finland have in collaboration with the University of Turku, Indiana University and two Finnish companies, Biotie Therapies Corp. and Pharmatest Services Ltd, discovered a novel mechanism regulating the development of breast cancer bone metastases and showed that heparin-like compounds can potentially be used to inhibit breast cancer metastasis to bone. http://medicalxpress.com/news/2012-05-heparin-like-compounds-inhibit-breast-cancer.html Cancer Mon, 21 May 2012 10:23:06 EST news256814519 Lymph nodes help to fight off infections by producing immune cells and filtering foreign materials from the body, such as bacteria or cancer cells. Thus, one of the first places that cancer cells are found when they leave the primary tumor is in the lymph nodes. The spread of cancer cells to the lymph nodes, lymphatic metastasis, is known to indicate a poor prognosis in many types of cancers; how tumor cells reach the lymph nodes, however, is not well understood. http://medicalxpress.com/news/2012-04-pathway-linked-breast-cancer-metastasis.html Cancer Mon, 02 Apr 2012 12:00:04 EST news252584321 A new study has identified a key mechanism that causes breast cancer to spread. The research, published by Cell Press on March 30th in the journal Molecular Cell, enhances our knowledge about the signals that drive cancer metastasis and identifies new therapeutic targets for a lethal form of invasive breast cancer that is notoriously resistant to treatment. http://medicalxpress.com/news/2012-03-mechanism-breast-cancer-invasive.html Cancer Thu, 29 Mar 2012 12:00:03 EST news252240001 (Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research together with colleagues from the University of Fribourg have discovered a signaling mechanism controlling mobility and metastasis in breast cancer. They have been able to thus reduce invasiveness of the cancer cells. This is promising for the development of therapies against the types of breast cancer that readily form metastasis and for which a therapy has yet to be found. http://medicalxpress.com/news/2012-03-inhibiting-cell-migration-breast-cancer.html Cancer Wed, 14 Mar 2012 10:06:50 EST news250938392 A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. http://medicalxpress.com/news/2011-12-synthetic-molecules-autoimmune-disease-mice.html Immunology Sun, 25 Dec 2011 13:00:01 EST news244013673 Researchers from the Harper Cancer Research Institute, a partnership between the University of Notre Dame and Indiana University School of Medicine-South Bend, have uncovered a key element that plays a role in the spread of ovarian cancer. http://medicalxpress.com/news/2011-11-exploring-important-insight-ovarian-cancer.html Cancer Mon, 07 Nov 2011 09:46:03 EST news239881554 A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011. http://medicalxpress.com/news/2011-10-fat-cells-abdomen-fuel-ovarian.html Cancer Sun, 30 Oct 2011 14:00:11 EST news239200932 Strong, incompatible views are common in biomedicine but are largely invisible to biomedical experts themselves, creating artificial barriers to effective modeling of complex biological phenomena. Researchers at the University of Chicago explored the diversity in views among scientists researching the process of cancer metastasis and found ubiquitous disagreement around assumptions in any model of the progression of cancer cells from their original location to other parts of the body. The researchers suggest that making often invisible assumptions explicit could significantly improve the modeling of biomedical processes. http://medicalxpress.com/news/2011-10-incompatible-assumptions-common-biomedical.html Medical research Thu, 06 Oct 2011 17:00:03 EST news237128787 A possible new target for breast cancer therapy comes from the discovery that the Tyk2 protein helps suppress the growth and metastasis of breast tumors, as reported in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. http://medicalxpress.com/news/2011-10-potential-therapeutic-breast-cancer.html Cancer Wed, 05 Oct 2011 16:18:58 EST news237050329 The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Modelling uses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone. http://medicalxpress.com/news/2011-10-cancer-ecological-principles.html Cancer Mon, 03 Oct 2011 03:55:13 EST news236832784 Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have made a landmark discovery in the battle against the rapid spread of aggressive cancers associated with PRL-3 oncoprotein . Contrary to the current accepted theory that antibodies can only bind to cancer proteins found on the cancer cell surface, the IMCB team led by Dr Zeng Qi is the first to discover that antibodies can in fact directly target intracellular oncoproteins like PRL-3 that reside within the cancer cells to suppress cancer growth successfully. This breakthrough finding will pave the way for more targeted solutions for cancer treatment and also offers hope for cancer prevention. http://medicalxpress.com/news/2011-09-scientists-headway-cancer-treatment-landmark.html Cancer Thu, 08 Sep 2011 09:49:51 EST news234694164 (Medical Xpress) -- Study uncovers several compounds that inhibit cancer cell invasion, but also reveals that cancer drug paclitaxel does the opposite -- it promotes cancer metastasis. http://medicalxpress.com/news/2011-07-high-throughput-screen-compounds-cancer-cell.html Cancer Tue, 26 Jul 2011 09:20:25 EST news230890805 Lung cancer is strongly correlated with smoking, and most lung cancer patients are current or former smokers. But it is not rare in nonsmokers. Now, a team of researchers from the H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, shows that a protein called ID1 is a key player in lung cancer in both smokers and nonsmokers. The research is published in the July issue of the journal Molecular and Cellular Biology. http://medicalxpress.com/news/2011-07-protein-boosts-lung-cancer-smokers.html Cancer Tue, 19 Jul 2011 09:55:08 EST news230288088 A compound that for about 60 years has been used as a drug against tapeworm infection is also apparently effective against colon cancer metastasis, as studies using mice have now shown. The compound silences a gene that triggers the formation of metastases in colon cancer. Professor Ulrike Stein (Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, (MDC)) and her research group made this discovery in collaboration with Professor Robert H. Shoemaker of the National Cancer Institute (NCI) in Frederick, Maryland. Plans are already underway with Professor Peter M. Schlag (Charite Comprehensive Cancer Center) to conduct a clinical trial. http://medicalxpress.com/news/2011-06-tapeworm-drug-inhibits-colon-cancer.html Cancer Fri, 17 Jun 2011 16:27:08 EST news227546795 In a study recently published in Cancer Research, Van Andel Research Institute (VARI) researchers found a protein that could help predict the spread of the head and neck cancer nasopharyngeal carcinoma (NPC); this protein could also serve as part of a treatment strategy to stop the spread of the disease. http://medicalxpress.com/news/2011-06-potential-predictor-deadly-cancer-common.html Cancer Tue, 14 Jun 2011 17:24:18 EST news227291046 A team led by Joan Brugge, the Louise Foote Pfeiffer Professor of Cell Biology at Harvard Medical School, recently shed light on how ovarian cancer spreads. In a paper published in the July edition of the journal Cancer Discovery, the newest journal of the American Association for Cancer Research, Brugge and colleagues found that ovarian cancer cells act like bullies, using brute force to plow their way through tissue and colonize additional organs. http://medicalxpress.com/news/2011-06-scientists-image-stages-ovarian-cancer.html Cancer Tue, 14 Jun 2011 13:38:29 EST news227277494 By shedding new light on how cells migrate in the developing brain, researchers at Fred Hutchinson Cancer Research Center also may have found a new mechanism by which other types of cells, including cancer cells, travel within the body. The findings by Jonathan Cooper, Ph.D., member and director of the Hutchinson Center's Basic Sciences Division, and Yves Jossin, Ph.D., a research fellow in Cooper's laboratory, published online April 24 in Nature Neuroscience, could lead to a better understanding of neurological development and, possibly, cancer metastasis. http://medicalxpress.com/news/2011-04-brain-cell-migration-insight-cancer.html Neuroscience Sun, 24 Apr 2011 13:44:20 EST news222871437