http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences. http://medicalxpress.com/news/2013-04-loss-tumor-suppressor-spop-cancer.html Cancer Mon, 01 Apr 2013 15:00:15 EST news284032822 Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research led by Duke Cancer Institute. http://medicalxpress.com/news/2013-03-immortality-gene-mutation-brain-tumors.html Cancer Mon, 18 Mar 2013 15:00:04 EST news282826572 In a major breakthrough for uterine serous carcinoma (USC)—a chemo-resistant, aggressive form of endometrial cancer, Yale researchers have defined the genetic landscape of USC tumors, findings that point to new treatment opportunities. http://medicalxpress.com/news/2013-01-genes-aggressive-endometrial-cancer.html Cancer Mon, 28 Jan 2013 15:00:08 EST news278589502 Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein present in several types of cancer, including breast and ovarian cancer, which could be helpful in preventing tumors from coming back. http://medicalxpress.com/news/2013-01-dna-repairing-protein-key-recurrence-cancers.html Cancer Mon, 28 Jan 2013 09:15:37 EST news278586924 Patients with HER2-positive breast cancer being treated with anti-HER2 therapy may be able to prevent or delay resistance to the therapy with the addition of a phosphatidylinositol-3 kinase inhibitor to their treatment regimens. http://medicalxpress.com/news/2013-01-treatment-pi3k-resistance-anti-her2-therapy.html Cancer Wed, 23 Jan 2013 13:59:45 EST news278171977 Cancer researchers are increasingly aware that in addition to genetic mutations in a cancer itself, characteristics of the surrounding tissue can promote or suppress tumor growth. One of these important tissue characteristics is inflammation – most cancers prosper in and attach to inflamed tissue and so many cancers have developed ways to create it. http://medicalxpress.com/news/2013-01-body-ibuprofen-sparc-inflammation-bladder.html Cancer Wed, 16 Jan 2013 12:00:01 EST news277556125 By harnessing the very qualities that make sickle cell disease a lethal blood disorder, a research team led by Duke Medicine and Jenomic, a private cancer research company in Carmel, Calif., has developed a way to deploy the misshapen red blood cells to fight cancer tumors. http://medicalxpress.com/news/2013-01-sickle-cells-potential-aggressive-cancer.html Cancer Wed, 09 Jan 2013 17:00:06 EST news276961342 A combination of the drugs pazopanib and paclitaxel shows promise in slowing anaplastic thyroid cancer (ATC), according to a Mayo Clinic-led study published in the journal Science Translational Medicine. The two drugs together resulted in greater anti-cancer activity in ATC than either drug alone, says lead researcher Keith Bible, M.D., Ph.D., a Mayo Clinic oncologist. http://medicalxpress.com/news/2013-01-two-drug-combination-deadly-thyroid-cancer.html Cancer Tue, 08 Jan 2013 16:42:32 EST news276885650 (Medical Xpress)—Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many pancreatic and prostate tumors, according to research at the National Institutes of Health. http://medicalxpress.com/news/2012-12-gene-variation-bladder-cancer-treatment.html Cancer Thu, 27 Dec 2012 15:52:04 EST news275845917 Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options. http://medicalxpress.com/news/2012-11-gene-involved-lung-tumor-growth.html Cancer Thu, 29 Nov 2012 16:43:03 EST news273429766 Yale researchers manipulated a tiny genetic switch and halted growth of aggressive lung cancer tumors in mice and even prevented tumors from forming. http://medicalxpress.com/news/2012-10-genetic-lung-cancer-tumors-mice.html Cancer Thu, 25 Oct 2012 12:00:09 EST news270382472 Whole genome sequencing—spelling out all 3 billion letters in the human genome—"is an obvious and powerful method for advancing our understanding of pancreatic cancer," according to a new study from TGen, Mayo Clinic and Scottsdale Healthcare published today. http://medicalxpress.com/news/2012-10-wgs-multiple-pancreatic-cancer-patients.html Cancer Wed, 10 Oct 2012 17:00:08 EST news269106114 Crizotinib is effective in shrinking tumors in patients with anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer, a cancer commonly found in people who never smoked, and should be the standard of care for advanced stages of this disease, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO), the International Association for the Study of Lung Cancer (IASLC) and The University of Chicago. http://medicalxpress.com/news/2012-09-crizotinib-tumor-size-patients-alk.html Cancer Thu, 06 Sep 2012 15:07:50 EST news266162854 While active monitoring of serum prostate specific antigen (PSA) levels in men over 50 has greatly improved early detection of prostate cancer, prediction of clinical outcomes after diagnosis remains a major challenge. Researchers from the University of Pittsburgh School of Medicine have found that a genetic abnormality known as copy number variation (CNV) in prostate cancer tumors, as well as in the benign prostate tissues adjacent to the tumor and in the blood of patients with prostate cancer, can predict whether a patient will experience a relapse, and the nature of the relapse — aggressive or indolent. Their report is published in the June issue of The American Journal of Pathology. http://medicalxpress.com/news/2012-05-genetic-abnormalities-benign-malignant-tissues.html Cancer Mon, 07 May 2012 04:21:22 EST news255583271 The feasibility of selecting treatment based on individual molecular characteristics was demonstrated in a first-of-its kind pancreatic cancer clinical trial reported today by the Translational Genomics Research Institute (TGen) and the Virginia G. Piper Cancer Center at Scottsdale Healthcare. http://medicalxpress.com/news/2012-04-pancreatic-cancer-clinical-trial-results.html Cancer Tue, 03 Apr 2012 09:51:24 EST news252665467 Pancreas cancer tumors spread quickly and are notoriously resistant to treatment, making them among the deadliest of malignancies. Their resistance to chemotherapy stems in part from a unique biological barrier the tumor builds around itself. Now scientists at Fred Hutchinson Cancer Research Center have found a way to break through that defense, and their research represents a potential breakthrough in the treatment of pancreas cancer. http://medicalxpress.com/news/2012-03-scientists-pancreas-cancer-treatment-barrier.html Cancer Mon, 19 Mar 2012 12:00:01 EST news251375099 (HealthDay) -- A sensitive and specific gene-based classifier can be used to identify BRAF mutant colon cancer tumors and a subpopulation of BRAF wild-type tumors with poor prognosis, according to a study published March 5 in the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-03-gene-based-poor-prognosis-colon-cancers.html Cancer Fri, 09 Mar 2012 05:30:01 EST news250490806 The humble aspirin may soon have a new role. Scientists from The City College of New York have developed a new aspirin compound that has great promise to be, not only an extremely potent cancer-fighter, but even safer than the classic medicine cabinet staple. http://medicalxpress.com/news/2012-03-nosh-aspirin-a-day-cancer.html Cancer Thu, 08 Mar 2012 13:32:28 EST news250435931 (Medical Xpress) -- Three research teams have published papers in Nature, that together offer evidence suggesting that isocitrate dehydrogenase (IDH) enzyme mutations may play a role in altering activity that could have an impact on whether or not cancerous tumors begin to grow. http://medicalxpress.com/news/2012-02-idh-enzyme-mutations-growth-cancer.html Medical research Thu, 16 Feb 2012 10:28:04 EST news248610418 Investigators at the Massachusetts General Hospital (MGH) Cancer Center have identified a new genetic signature associated with bile duct cancer, a usually deadly tumor for which effective treatment currently is limited. Their report, which has been published online in The Oncologist, finds that growth-enhancing mutations in two related genes may account for nearly a quarter of bile duct tumors arising within the liver, presenting the possibility that drugs targeting this mutation could represent a new strategy to control tumor growth. http://medicalxpress.com/news/2012-01-gene-mutations-bile-duct-cancer.html Cancer Wed, 18 Jan 2012 14:36:58 EST news246119693 The investigational drug ganetespib, a synthetic second-generation Hsp90 inhibitor, slowed the growth of cancer cells taken from non-small cell lung cancer tumors with a mutation in the KRAS gene. The drug was even more active when combined with traditional lung cancer treatments and other investigational targeted therapies, according to preclinical study data. http://medicalxpress.com/news/2012-01-ganetespib-kras-mutant-nsclc-monotherapy-combinations.html Cancer Wed, 11 Jan 2012 05:06:54 EST news245480807 A combination of drugs that target estrogen production significantly reduced the number of tobacco carcinogen-induced lung tumors in mice, according to results from a preclinical study. http://medicalxpress.com/news/2012-01-estrogen-targeting-drug-combo-lung-cancer.html Cancer Mon, 09 Jan 2012 15:56:06 EST news245346950 The prominent US journal Science on Thursday retracted a 2009 report linking a mouse retrovirus to chronic fatigue syndrome after it was disproved by researchers earlier this year. http://medicalxpress.com/news/2011-12-journal-retracts-mouse-virus-link.html Medical research Thu, 22 Dec 2011 12:14:40 EST news243778460 A Wayne State University researcher has shown that compounds found in soybeans can make radiation treatment of lung cancer tumors more effective while helping to preserve normal tissue. http://medicalxpress.com/news/2011-12-soybean-compounds-effects-cancer-radiotherapy.html Cancer Mon, 19 Dec 2011 07:19:46 EST news243501277 A new class of anti-inflammatory drugs may one day serve as an alternative to steroid medications and possibly help avoid the serious side effects of steroids, based on research findings at the Salk Institute for Biological Studies. http://medicalxpress.com/news/2011-10-anti-inflammatory-drugs-side-effects-steroids.html Inflammatory disorders Tue, 25 Oct 2011 10:56:54 EST news238758997 The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity. http://medicalxpress.com/news/2011-08-tumor-suppressor-obesity.html Medical research Thu, 25 Aug 2011 12:56:55 EST news233495785